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Characterization of the internal working-life exposome using minimally and non-invasive sampling methods - a narrative review

Verscheure, Eline ; Stierum, Rob ; Schlünssen, Vivi ; Lund Würtz, Anne Mette ; Vanneste, Dorian ; Kogevinas, Manolis ; Harding, Barbara N. ; Broberg, Karin LU orcid ; Zienolddiny-Narui, Shan and Erdem, Johanna Samulin , et al. (2023) In Environmental Research 238.
Abstract

During recent years, we are moving away from the ‘one exposure, one disease’-approach in occupational settings and towards a more comprehensive approach, taking into account the totality of exposures during a life course by using an exposome approach. Taking an exposome approach however is accompanied by many challenges, one of which, for example, relates to the collection of biological samples. Methods used for sample collection in occupational exposome studies should ideally be minimally invasive, while at the same time sensitive, and enable meaningful repeated sampling in a large population and over a longer time period. This might be hampered in specific situations e.g., people working in remote areas, during pandemics or with... (More)

During recent years, we are moving away from the ‘one exposure, one disease’-approach in occupational settings and towards a more comprehensive approach, taking into account the totality of exposures during a life course by using an exposome approach. Taking an exposome approach however is accompanied by many challenges, one of which, for example, relates to the collection of biological samples. Methods used for sample collection in occupational exposome studies should ideally be minimally invasive, while at the same time sensitive, and enable meaningful repeated sampling in a large population and over a longer time period. This might be hampered in specific situations e.g., people working in remote areas, during pandemics or with flexible work hours. In these situations, using self-sampling techniques might offer a solution. Therefore, our aim was to identify existing self-sampling techniques and to evaluate the applicability of these techniques in an occupational exposome context by conducting a literature review. We here present an overview of current self-sampling methodologies used to characterize the internal exposome. In addition, the use of different biological matrices was evaluated and subdivided based on their level of invasiveness and applicability in an occupational exposome context. In conclusion, this review and the overview of self-sampling techniques presented herein can serve as a guide in the design of future (occupational) exposome studies while circumventing sample collection challenges associated with exposome studies.

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publication status
published
subject
keywords
Biomarker, Biomonitoring, Data availability, Exposome, Non-invasive sampling, Occupational, Self-sampling
in
Environmental Research
volume
238
article number
117001
publisher
Elsevier
external identifiers
  • pmid:37683788
  • scopus:85172252063
ISSN
0013-9351
DOI
10.1016/j.envres.2023.117001
language
English
LU publication?
yes
id
55a9530f-38d4-451f-a690-5ac60f16b184
date added to LUP
2023-12-05 14:21:42
date last changed
2024-04-18 10:56:45
@article{55a9530f-38d4-451f-a690-5ac60f16b184,
  abstract     = {{<p>During recent years, we are moving away from the ‘one exposure, one disease’-approach in occupational settings and towards a more comprehensive approach, taking into account the totality of exposures during a life course by using an exposome approach. Taking an exposome approach however is accompanied by many challenges, one of which, for example, relates to the collection of biological samples. Methods used for sample collection in occupational exposome studies should ideally be minimally invasive, while at the same time sensitive, and enable meaningful repeated sampling in a large population and over a longer time period. This might be hampered in specific situations e.g., people working in remote areas, during pandemics or with flexible work hours. In these situations, using self-sampling techniques might offer a solution. Therefore, our aim was to identify existing self-sampling techniques and to evaluate the applicability of these techniques in an occupational exposome context by conducting a literature review. We here present an overview of current self-sampling methodologies used to characterize the internal exposome. In addition, the use of different biological matrices was evaluated and subdivided based on their level of invasiveness and applicability in an occupational exposome context. In conclusion, this review and the overview of self-sampling techniques presented herein can serve as a guide in the design of future (occupational) exposome studies while circumventing sample collection challenges associated with exposome studies.</p>}},
  author       = {{Verscheure, Eline and Stierum, Rob and Schlünssen, Vivi and Lund Würtz, Anne Mette and Vanneste, Dorian and Kogevinas, Manolis and Harding, Barbara N. and Broberg, Karin and Zienolddiny-Narui, Shan and Erdem, Johanna Samulin and Das, Mrinal K. and Makris, Konstantinos C. and Konstantinou, Corina and Andrianou, Xanthi and Dekkers, Susan and Morris, Lorna and Pronk, Anjoeka and Godderis, Lode and Ghosh, Manosij}},
  issn         = {{0013-9351}},
  keywords     = {{Biomarker; Biomonitoring; Data availability; Exposome; Non-invasive sampling; Occupational; Self-sampling}},
  language     = {{eng}},
  month        = {{12}},
  publisher    = {{Elsevier}},
  series       = {{Environmental Research}},
  title        = {{Characterization of the internal working-life exposome using minimally and non-invasive sampling methods - a narrative review}},
  url          = {{http://dx.doi.org/10.1016/j.envres.2023.117001}},
  doi          = {{10.1016/j.envres.2023.117001}},
  volume       = {{238}},
  year         = {{2023}},
}