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Lactadherin binds to elastin - a starting point for medin amyloid formation?

Larsson, Annika ; Peng, Siwei ; Persson, Helena LU ; Rosenbloom, Joel ; Abrams, William R. ; Wassberg, Erik ; Thelin, Stefan ; Sletten, Knut ; Gerwins, Par and Westermark, Per (2006) In Amyloid 13(2). p.78-85
Abstract
Medin amyloid is found in the medial layer of the aorta in almost 100% of the Caucasian population over 50 years of age. The medin fragment is 5.5 kDa and derives from the C2-like domain of the precursor protein lactadherin. We have previously reported immunohistochemical findings showing that medin amyloid co-localizes with elastic fibers of arteries and herein we show that lactadherin also is associated with elastic structures of human aortic material. In addition, results from in vitro binding assays demonstrate that both medin and lactadherin bind to tropoelastin in a concentration-dependent fashion, suggesting that the lactadherin-tropoelastin interaction is mediated via the medin domain. It is possible that lactadherin, which is a... (More)
Medin amyloid is found in the medial layer of the aorta in almost 100% of the Caucasian population over 50 years of age. The medin fragment is 5.5 kDa and derives from the C2-like domain of the precursor protein lactadherin. We have previously reported immunohistochemical findings showing that medin amyloid co-localizes with elastic fibers of arteries and herein we show that lactadherin also is associated with elastic structures of human aortic material. In addition, results from in vitro binding assays demonstrate that both medin and lactadherin bind to tropoelastin in a concentration-dependent fashion, suggesting that the lactadherin-tropoelastin interaction is mediated via the medin domain. It is possible that lactadherin, which is a cell adhesion protein, in this way connects smooth muscle cells to the elastic fibers of arteries. Given that both medin and lactadherin interact with elastic fibers, elastin is probably an important component in the formation of medin amyloid. (Less)
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
tropoelastin, lactadherin, medin, elastin, elastic fiber, amyloid, aorta
in
Amyloid
volume
13
issue
2
pages
78 - 85
publisher
Parthenon Publishing
external identifiers
  • wos:000240931800003
  • scopus:33747619664
ISSN
1350-6129
DOI
10.1080/13506120600722530
language
English
LU publication?
yes
id
55def4a4-d674-43b3-999c-4877ea4a3623 (old id 389830)
date added to LUP
2016-04-01 15:35:41
date last changed
2020-07-01 03:08:29
@article{55def4a4-d674-43b3-999c-4877ea4a3623,
  abstract     = {Medin amyloid is found in the medial layer of the aorta in almost 100% of the Caucasian population over 50 years of age. The medin fragment is 5.5 kDa and derives from the C2-like domain of the precursor protein lactadherin. We have previously reported immunohistochemical findings showing that medin amyloid co-localizes with elastic fibers of arteries and herein we show that lactadherin also is associated with elastic structures of human aortic material. In addition, results from in vitro binding assays demonstrate that both medin and lactadherin bind to tropoelastin in a concentration-dependent fashion, suggesting that the lactadherin-tropoelastin interaction is mediated via the medin domain. It is possible that lactadherin, which is a cell adhesion protein, in this way connects smooth muscle cells to the elastic fibers of arteries. Given that both medin and lactadherin interact with elastic fibers, elastin is probably an important component in the formation of medin amyloid.},
  author       = {Larsson, Annika and Peng, Siwei and Persson, Helena and Rosenbloom, Joel and Abrams, William R. and Wassberg, Erik and Thelin, Stefan and Sletten, Knut and Gerwins, Par and Westermark, Per},
  issn         = {1350-6129},
  language     = {eng},
  number       = {2},
  pages        = {78--85},
  publisher    = {Parthenon Publishing},
  series       = {Amyloid},
  title        = {Lactadherin binds to elastin - a starting point for medin amyloid formation?},
  url          = {http://dx.doi.org/10.1080/13506120600722530},
  doi          = {10.1080/13506120600722530},
  volume       = {13},
  year         = {2006},
}