Prolonged NoGo P3 latency as a possible neurobehavioral correlate of aggressive and antisocial behaviors : A Go/NoGo ERP study
(2022) In Biological Psychology 168.- Abstract
Aggressive and antisocial behaviors are detrimental to society and constitute major challenges in forensic mental health settings, yet the associated neural circuitry remains poorly understood. Here, we investigated differences in aggressive and antisocial behaviors between healthy controls (n = 20) and violent mentally disordered offenders (MDOs; n = 26), and examined associations between aggressive and antisocial behaviors, behavioral inhibitory control, and neurophysiological activity across the whole sample (n = 46). Event-related potentials were obtained using EEG while participants completed a Go/NoGo response inhibition task, and aggressive and antisocial behaviors were assessed with the Life History of Aggression (LHA)... (More)
Aggressive and antisocial behaviors are detrimental to society and constitute major challenges in forensic mental health settings, yet the associated neural circuitry remains poorly understood. Here, we investigated differences in aggressive and antisocial behaviors between healthy controls (n = 20) and violent mentally disordered offenders (MDOs; n = 26), and examined associations between aggressive and antisocial behaviors, behavioral inhibitory control, and neurophysiological activity across the whole sample (n = 46). Event-related potentials were obtained using EEG while participants completed a Go/NoGo response inhibition task, and aggressive and antisocial behaviors were assessed with the Life History of Aggression (LHA) instrument. Using a robust Bayesian linear regression approach, we found that MDOs scored substantially higher than healthy controls on LHA Aggression and Antisocial subscales. Using the whole sample and after adjusting for age, we found that scores on the LHA Aggression and Antisocial subscales were robustly associated with longer NoGo P3 latency, and less robustly with longer NoGo N2 latency. Post-hoc analyzes suggested that healthy controls and MDOs exhibited similar associations. With several limitations in mind, we suggest that prolonged NoGo P3 latency, reflecting decreased neural efficiency during the later stages of conflict monitoring or outcome evaluation, is a potential neurobehavioral correlate of aggressive and antisocial behaviors.
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- author
- Delfin, Carl LU ; Wallinius, Märta LU ; Björnsdotter, Malin ; Ruzich, Emily and Andiné, Peter
- organization
- publishing date
- 2022-02
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aggression, Antisocial behaviors, Event-related potentials, Go/NoGo
- in
- Biological Psychology
- volume
- 168
- article number
- 108245
- publisher
- Elsevier
- external identifiers
-
- scopus:85121906906
- pmid:34958853
- ISSN
- 0301-0511
- DOI
- 10.1016/j.biopsycho.2021.108245
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2021 The Authors
- id
- 55f38b23-737c-421e-b5df-207cb24c470c
- date added to LUP
- 2022-02-24 14:47:04
- date last changed
- 2024-06-15 19:31:02
@article{55f38b23-737c-421e-b5df-207cb24c470c,
abstract = {{<p>Aggressive and antisocial behaviors are detrimental to society and constitute major challenges in forensic mental health settings, yet the associated neural circuitry remains poorly understood. Here, we investigated differences in aggressive and antisocial behaviors between healthy controls (n = 20) and violent mentally disordered offenders (MDOs; n = 26), and examined associations between aggressive and antisocial behaviors, behavioral inhibitory control, and neurophysiological activity across the whole sample (n = 46). Event-related potentials were obtained using EEG while participants completed a Go/NoGo response inhibition task, and aggressive and antisocial behaviors were assessed with the Life History of Aggression (LHA) instrument. Using a robust Bayesian linear regression approach, we found that MDOs scored substantially higher than healthy controls on LHA Aggression and Antisocial subscales. Using the whole sample and after adjusting for age, we found that scores on the LHA Aggression and Antisocial subscales were robustly associated with longer NoGo P3 latency, and less robustly with longer NoGo N2 latency. Post-hoc analyzes suggested that healthy controls and MDOs exhibited similar associations. With several limitations in mind, we suggest that prolonged NoGo P3 latency, reflecting decreased neural efficiency during the later stages of conflict monitoring or outcome evaluation, is a potential neurobehavioral correlate of aggressive and antisocial behaviors.</p>}},
author = {{Delfin, Carl and Wallinius, Märta and Björnsdotter, Malin and Ruzich, Emily and Andiné, Peter}},
issn = {{0301-0511}},
keywords = {{Aggression; Antisocial behaviors; Event-related potentials; Go/NoGo}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Biological Psychology}},
title = {{Prolonged NoGo P3 latency as a possible neurobehavioral correlate of aggressive and antisocial behaviors : A Go/NoGo ERP study}},
url = {{http://dx.doi.org/10.1016/j.biopsycho.2021.108245}},
doi = {{10.1016/j.biopsycho.2021.108245}},
volume = {{168}},
year = {{2022}},
}