Advanced

Botulinum and tetanus neurotoxins

Dong, Min ; Masuyer, Geoffrey and Stenmark, Pål LU (2019) In Annual Review of Biochemistry 88. p.811-837
Abstract

Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as therapeutic toxins. They contain three functional domains responsible for receptor-binding, membrane translocation, and proteolytic cleavage of host proteins required for synaptic vesicle exocytosis. These toxins also have distinct features: BoNTs exist within a progenitor toxin complex (PTC), which protects the toxin and facilitates its absorption in the gastrointestinal tract, whereas TeNT is uniquely transported retrogradely within motor neurons. Our increasing knowledge of these toxins has allowed the development of engineered toxins for medical uses. The... (More)

Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as therapeutic toxins. They contain three functional domains responsible for receptor-binding, membrane translocation, and proteolytic cleavage of host proteins required for synaptic vesicle exocytosis. These toxins also have distinct features: BoNTs exist within a progenitor toxin complex (PTC), which protects the toxin and facilitates its absorption in the gastrointestinal tract, whereas TeNT is uniquely transported retrogradely within motor neurons. Our increasing knowledge of these toxins has allowed the development of engineered toxins for medical uses. The discovery of new BoNTs and BoNT-like proteins provides additional tools to understand the evolution of the toxins and to engineer toxin-based therapeutics. This review summarizes the progress on our understanding of BoNTs and TeNT, focusing on the PTC, receptor recognition, new BoNT-like toxins, and therapeutic toxin engineering.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bacterial toxin, botulinum neurotoxin, clostridium, protein engineering, tetanus neurotoxin, toxin
in
Annual Review of Biochemistry
volume
88
pages
27 pages
publisher
Annual Reviews
external identifiers
  • scopus:85067790070
ISSN
0066-4154
DOI
10.1146/annurev-biochem-013118-111654
language
English
LU publication?
yes
id
55fc66e5-9d6b-40ce-b4f7-61faee60a7a1
date added to LUP
2019-07-04 16:36:44
date last changed
2019-11-20 05:49:56
@article{55fc66e5-9d6b-40ce-b4f7-61faee60a7a1,
  abstract     = {<p>Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as therapeutic toxins. They contain three functional domains responsible for receptor-binding, membrane translocation, and proteolytic cleavage of host proteins required for synaptic vesicle exocytosis. These toxins also have distinct features: BoNTs exist within a progenitor toxin complex (PTC), which protects the toxin and facilitates its absorption in the gastrointestinal tract, whereas TeNT is uniquely transported retrogradely within motor neurons. Our increasing knowledge of these toxins has allowed the development of engineered toxins for medical uses. The discovery of new BoNTs and BoNT-like proteins provides additional tools to understand the evolution of the toxins and to engineer toxin-based therapeutics. This review summarizes the progress on our understanding of BoNTs and TeNT, focusing on the PTC, receptor recognition, new BoNT-like toxins, and therapeutic toxin engineering.</p>},
  author       = {Dong, Min and Masuyer, Geoffrey and Stenmark, Pål},
  issn         = {0066-4154},
  language     = {eng},
  pages        = {811--837},
  publisher    = {Annual Reviews},
  series       = {Annual Review of Biochemistry},
  title        = {Botulinum and tetanus neurotoxins},
  url          = {http://dx.doi.org/10.1146/annurev-biochem-013118-111654},
  doi          = {10.1146/annurev-biochem-013118-111654},
  volume       = {88},
  year         = {2019},
}