Botulinum and tetanus neurotoxins
Dong, Min ; Masuyer, Geoffrey and Stenmark, Pål LU
(2019)
In Annual Review of Biochemistry
88.
p.811-837
- Abstract
Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as therapeutic toxins. They contain three functional domains responsible for receptor-binding, membrane translocation, and proteolytic cleavage of host proteins required for synaptic vesicle exocytosis. These toxins also have distinct features: BoNTs exist within a progenitor toxin complex (PTC), which protects the toxin and facilitates its absorption in the gastrointestinal tract, whereas TeNT is uniquely transported retrogradely within motor neurons. Our increasing knowledge of these toxins has allowed the development of engineered toxins for medical uses. The... (More)
Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as therapeutic toxins. They contain three functional domains responsible for receptor-binding, membrane translocation, and proteolytic cleavage of host proteins required for synaptic vesicle exocytosis. These toxins also have distinct features: BoNTs exist within a progenitor toxin complex (PTC), which protects the toxin and facilitates its absorption in the gastrointestinal tract, whereas TeNT is uniquely transported retrogradely within motor neurons. Our increasing knowledge of these toxins has allowed the development of engineered toxins for medical uses. The discovery of new BoNTs and BoNT-like proteins provides additional tools to understand the evolution of the toxins and to engineer toxin-based therapeutics. This review summarizes the progress on our understanding of BoNTs and TeNT, focusing on the PTC, receptor recognition, new BoNT-like toxins, and therapeutic toxin engineering.
(Less)
- author
- Dong, Min
; Masuyer, Geoffrey
and Stenmark, Pål
LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- bacterial toxin, botulinum neurotoxin, clostridium, protein engineering, tetanus neurotoxin, toxin
- in
- Annual Review of Biochemistry
- volume
- 88
- pages
- 27 pages
- publisher
- Annual Reviews
- external identifiers
-
- scopus:85067790070
- pmid:30388027
- ISSN
- 0066-4154
- DOI
- 10.1146/annurev-biochem-013118-111654
- language
- English
- LU publication?
- yes
- id
- 55fc66e5-9d6b-40ce-b4f7-61faee60a7a1
- date added to LUP
- 2019-07-04 16:36:44
- date last changed
- 2024-06-27 00:38:54
@article{55fc66e5-9d6b-40ce-b4f7-61faee60a7a1,
abstract = {{<p>Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as therapeutic toxins. They contain three functional domains responsible for receptor-binding, membrane translocation, and proteolytic cleavage of host proteins required for synaptic vesicle exocytosis. These toxins also have distinct features: BoNTs exist within a progenitor toxin complex (PTC), which protects the toxin and facilitates its absorption in the gastrointestinal tract, whereas TeNT is uniquely transported retrogradely within motor neurons. Our increasing knowledge of these toxins has allowed the development of engineered toxins for medical uses. The discovery of new BoNTs and BoNT-like proteins provides additional tools to understand the evolution of the toxins and to engineer toxin-based therapeutics. This review summarizes the progress on our understanding of BoNTs and TeNT, focusing on the PTC, receptor recognition, new BoNT-like toxins, and therapeutic toxin engineering.</p>}},
author = {{Dong, Min and Masuyer, Geoffrey and Stenmark, Pål}},
issn = {{0066-4154}},
keywords = {{bacterial toxin; botulinum neurotoxin; clostridium; protein engineering; tetanus neurotoxin; toxin}},
language = {{eng}},
pages = {{811--837}},
publisher = {{Annual Reviews}},
series = {{Annual Review of Biochemistry}},
title = {{Botulinum and tetanus neurotoxins}},
url = {{http://dx.doi.org/10.1146/annurev-biochem-013118-111654}},
doi = {{10.1146/annurev-biochem-013118-111654}},
volume = {{88}},
year = {{2019}},
}