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Biological and environmental predictors of heterogeneity in neurocognitive ageing : Evidence from Betula and other longitudinal studies

Nyberg, Lars ; Boraxbekk, Carl Johan ; Sörman, Daniel Eriksson ; Hansson, Patrik ; Herlitz, Agneta ; Kauppi, Karolina ; Ljungberg, Jessica K. ; Lövheim, Hugo ; Lundquist, Anders and Adolfsson, Annelie Nordin , et al. (2020) In Ageing Research Reviews 64.
Abstract

Individual differences in cognitive performance increase with advancing age, reflecting marked cognitive changes in some individuals along with little or no change in others. Genetic and lifestyle factors are assumed to influence cognitive performance in ageing by affecting the magnitude and extent of age-related brain changes (i.e., brain maintenance or atrophy), as well as the ability to recruit compensatory processes. The purpose of this review is to present findings from the Betula study and other longitudinal studies, with a focus on clarifying the role of key biological and environmental factors assumed to underlie individual differences in brain and cognitive ageing. We discuss the vital importance of sampling, analytic methods,... (More)

Individual differences in cognitive performance increase with advancing age, reflecting marked cognitive changes in some individuals along with little or no change in others. Genetic and lifestyle factors are assumed to influence cognitive performance in ageing by affecting the magnitude and extent of age-related brain changes (i.e., brain maintenance or atrophy), as well as the ability to recruit compensatory processes. The purpose of this review is to present findings from the Betula study and other longitudinal studies, with a focus on clarifying the role of key biological and environmental factors assumed to underlie individual differences in brain and cognitive ageing. We discuss the vital importance of sampling, analytic methods, consideration of non-ignorable dropout, and related issues for valid conclusions on factors that influence healthy neurocognitive ageing.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ageing, brain, brain maintenance, cognitive reserve, genetics, lifestyle, longitudinal, memory
in
Ageing Research Reviews
volume
64
article number
101184
publisher
Elsevier
external identifiers
  • pmid:32992046
  • scopus:85092710312
ISSN
1568-1637
DOI
10.1016/j.arr.2020.101184
language
English
LU publication?
yes
id
56155b0f-8e8f-4cc6-bec2-113f82cbf709
date added to LUP
2020-11-05 11:15:27
date last changed
2024-05-02 18:42:10
@article{56155b0f-8e8f-4cc6-bec2-113f82cbf709,
  abstract     = {{<p>Individual differences in cognitive performance increase with advancing age, reflecting marked cognitive changes in some individuals along with little or no change in others. Genetic and lifestyle factors are assumed to influence cognitive performance in ageing by affecting the magnitude and extent of age-related brain changes (i.e., brain maintenance or atrophy), as well as the ability to recruit compensatory processes. The purpose of this review is to present findings from the Betula study and other longitudinal studies, with a focus on clarifying the role of key biological and environmental factors assumed to underlie individual differences in brain and cognitive ageing. We discuss the vital importance of sampling, analytic methods, consideration of non-ignorable dropout, and related issues for valid conclusions on factors that influence healthy neurocognitive ageing.</p>}},
  author       = {{Nyberg, Lars and Boraxbekk, Carl Johan and Sörman, Daniel Eriksson and Hansson, Patrik and Herlitz, Agneta and Kauppi, Karolina and Ljungberg, Jessica K. and Lövheim, Hugo and Lundquist, Anders and Adolfsson, Annelie Nordin and Oudin, Anna and Pudas, Sara and Rönnlund, Michael and Stiernstedt, Mikael and Sundström, Anna and Adolfsson, Rolf}},
  issn         = {{1568-1637}},
  keywords     = {{ageing; brain; brain maintenance, cognitive reserve; genetics; lifestyle; longitudinal; memory}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Ageing Research Reviews}},
  title        = {{Biological and environmental predictors of heterogeneity in neurocognitive ageing : Evidence from Betula and other longitudinal studies}},
  url          = {{http://dx.doi.org/10.1016/j.arr.2020.101184}},
  doi          = {{10.1016/j.arr.2020.101184}},
  volume       = {{64}},
  year         = {{2020}},
}