Growth Hormone Improves Ovarian Follicle Health in Premature Ovarian Failure Mice by Reducing Apoptosis : (GH Improves Ovarian Follicle Health in POF Mice by Reducing Apoptosis)
(2025) In Reproductive Sciences 32(5). p.1730-1742- Abstract
Premature ovarian failure (POF) is a perplexing condition in women characterized by cessation of oocyte production in the ovaries. Despite numerous proposed causes for the development of POF, the actual cause of the most POF cases remains unknown. Given that POF significantly affects fertility and is a devastating diagnosis for women, there is an urgent need for the development of new therapies aimed at reducing the long-term health consequences associated with POF. To explore the functions and potential mechanisms of growth hormone (GH) in ovarian development, follicle formation, and oocyte production, we created a mouse model of premature ovarian failure (POF) by administering cisplatin via intraperitoneal injection. Subsequently, we... (More)
Premature ovarian failure (POF) is a perplexing condition in women characterized by cessation of oocyte production in the ovaries. Despite numerous proposed causes for the development of POF, the actual cause of the most POF cases remains unknown. Given that POF significantly affects fertility and is a devastating diagnosis for women, there is an urgent need for the development of new therapies aimed at reducing the long-term health consequences associated with POF. To explore the functions and potential mechanisms of growth hormone (GH) in ovarian development, follicle formation, and oocyte production, we created a mouse model of premature ovarian failure (POF) by administering cisplatin via intraperitoneal injection. Subsequently, we investigated the role of GH in attenuating the POF-induced effects. Our findings demonstrate that GH effectively improves the ovarian coefficient, promotes follicular development, and increases the quantity of oocytes. To explore the functions and potential mechanisms of growth hormone (GH) in ovarian development, follicle formation, and oocyte production, we created a mouse model of premature ovarian failure (POF) by administering cisplatin via intraperitoneal injection. Subsequently, we investigated the role of GH in attenuating the POF-induced effects. Our findings demonstrate that GH effectively improves the ovarian coefficient, promotes follicular development, and increases the quantity of oocytes.
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- author
- Hong, Ziwei ; Ni, Xinyi ; Zhou, Liying ; Ji, Hong ; Yang, Daowei LU ; Sui, Hongshu and Wang, Hailong
- organization
- publishing date
- 2025
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Apoptosis, GH, Mitochondria, Oocyte, POF
- in
- Reproductive Sciences
- volume
- 32
- issue
- 5
- pages
- 13 pages
- publisher
- Springer Nature
- external identifiers
-
- pmid:40029544
- scopus:86000263251
- ISSN
- 1933-7191
- DOI
- 10.1007/s43032-025-01822-w
- language
- English
- LU publication?
- yes
- id
- 5641158d-1ee3-421b-b28f-03ed60bf5337
- date added to LUP
- 2025-06-26 08:20:07
- date last changed
- 2025-07-10 08:53:17
@article{5641158d-1ee3-421b-b28f-03ed60bf5337,
abstract = {{<p>Premature ovarian failure (POF) is a perplexing condition in women characterized by cessation of oocyte production in the ovaries. Despite numerous proposed causes for the development of POF, the actual cause of the most POF cases remains unknown. Given that POF significantly affects fertility and is a devastating diagnosis for women, there is an urgent need for the development of new therapies aimed at reducing the long-term health consequences associated with POF. To explore the functions and potential mechanisms of growth hormone (GH) in ovarian development, follicle formation, and oocyte production, we created a mouse model of premature ovarian failure (POF) by administering cisplatin via intraperitoneal injection. Subsequently, we investigated the role of GH in attenuating the POF-induced effects. Our findings demonstrate that GH effectively improves the ovarian coefficient, promotes follicular development, and increases the quantity of oocytes. To explore the functions and potential mechanisms of growth hormone (GH) in ovarian development, follicle formation, and oocyte production, we created a mouse model of premature ovarian failure (POF) by administering cisplatin via intraperitoneal injection. Subsequently, we investigated the role of GH in attenuating the POF-induced effects. Our findings demonstrate that GH effectively improves the ovarian coefficient, promotes follicular development, and increases the quantity of oocytes.</p>}},
author = {{Hong, Ziwei and Ni, Xinyi and Zhou, Liying and Ji, Hong and Yang, Daowei and Sui, Hongshu and Wang, Hailong}},
issn = {{1933-7191}},
keywords = {{Apoptosis; GH; Mitochondria; Oocyte; POF}},
language = {{eng}},
number = {{5}},
pages = {{1730--1742}},
publisher = {{Springer Nature}},
series = {{Reproductive Sciences}},
title = {{Growth Hormone Improves Ovarian Follicle Health in Premature Ovarian Failure Mice by Reducing Apoptosis : (GH Improves Ovarian Follicle Health in POF Mice by Reducing Apoptosis)}},
url = {{http://dx.doi.org/10.1007/s43032-025-01822-w}},
doi = {{10.1007/s43032-025-01822-w}},
volume = {{32}},
year = {{2025}},
}