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Mandibulotomy access to tumour sites : fewer complications for postoperative compared with preoperative radiotherapy

Carlwig, K. LU ; Fransson, P. LU ; Bengtsson, M. LU orcid ; Gebre-Medhin, M. LU ; Sjövall, J. LU and Greiff, L. LU (2021) In International Journal of Oral and Maxillofacial Surgery 50(7). p.851-856
Abstract

The purpose of this study was to compare complication rates at the mandibulotomy site between patients receiving preoperative radiotherapy (RT) and those receiving postoperative RT during treatment for oral and oropharyngeal cancer where the surgical procedure required a mandibular osteotomy to gain access to the tumour. Sixty-four consecutive patients treated during the period 2000–2015 were available for analysis. Their medical records were reviewed retrospectively. All patients were followed for at least 1 year postoperatively. A subgroup of patients received RT on several occasions or long before the mandibulotomy, therefore the statistical comparisons focused on the two groups of patients receiving RT on one occasion and within 6... (More)

The purpose of this study was to compare complication rates at the mandibulotomy site between patients receiving preoperative radiotherapy (RT) and those receiving postoperative RT during treatment for oral and oropharyngeal cancer where the surgical procedure required a mandibular osteotomy to gain access to the tumour. Sixty-four consecutive patients treated during the period 2000–2015 were available for analysis. Their medical records were reviewed retrospectively. All patients were followed for at least 1 year postoperatively. A subgroup of patients received RT on several occasions or long before the mandibulotomy, therefore the statistical comparisons focused on the two groups of patients receiving RT on one occasion and within 6 months prior to or following surgery. Seventeen patients presented a total of 29 complications, yielding an overall complication rate of 27%. Orocutaneous fistula was the most common complication. Patients who received RT preoperatively presented a higher complication rate (9/15; 60%) when compared to those who received RT postoperatively (2/31; 6.5%) (odds ratio 21.8, P < 0.001). This study demonstrated fewer complications in the mandibulotomy area exposed to postoperative RT compared with preoperative RT. It is therefore suggested that, when possible, RT should be given postoperatively if combination treatment with RT and surgery, including a mandibulotomy, is planned.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
head and neck neoplasms, mandibular osteotomy, mouth neoplasms, oropharyngeal neoplasms, postoperative complications, radiotherapy
in
International Journal of Oral and Maxillofacial Surgery
volume
50
issue
7
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:85096867988
  • pmid:33248870
ISSN
0901-5027
DOI
10.1016/j.ijom.2020.11.004
language
English
LU publication?
yes
id
5666c574-2453-4c6f-9e9e-533748365efd
date added to LUP
2020-12-14 09:29:54
date last changed
2024-06-13 02:02:46
@article{5666c574-2453-4c6f-9e9e-533748365efd,
  abstract     = {{<p>The purpose of this study was to compare complication rates at the mandibulotomy site between patients receiving preoperative radiotherapy (RT) and those receiving postoperative RT during treatment for oral and oropharyngeal cancer where the surgical procedure required a mandibular osteotomy to gain access to the tumour. Sixty-four consecutive patients treated during the period 2000–2015 were available for analysis. Their medical records were reviewed retrospectively. All patients were followed for at least 1 year postoperatively. A subgroup of patients received RT on several occasions or long before the mandibulotomy, therefore the statistical comparisons focused on the two groups of patients receiving RT on one occasion and within 6 months prior to or following surgery. Seventeen patients presented a total of 29 complications, yielding an overall complication rate of 27%. Orocutaneous fistula was the most common complication. Patients who received RT preoperatively presented a higher complication rate (9/15; 60%) when compared to those who received RT postoperatively (2/31; 6.5%) (odds ratio 21.8, P &lt; 0.001). This study demonstrated fewer complications in the mandibulotomy area exposed to postoperative RT compared with preoperative RT. It is therefore suggested that, when possible, RT should be given postoperatively if combination treatment with RT and surgery, including a mandibulotomy, is planned.</p>}},
  author       = {{Carlwig, K. and Fransson, P. and Bengtsson, M. and Gebre-Medhin, M. and Sjövall, J. and Greiff, L.}},
  issn         = {{0901-5027}},
  keywords     = {{head and neck neoplasms; mandibular osteotomy; mouth neoplasms; oropharyngeal neoplasms; postoperative complications; radiotherapy}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{7}},
  pages        = {{851--856}},
  publisher    = {{Elsevier}},
  series       = {{International Journal of Oral and Maxillofacial Surgery}},
  title        = {{Mandibulotomy access to tumour sites : fewer complications for postoperative compared with preoperative radiotherapy}},
  url          = {{http://dx.doi.org/10.1016/j.ijom.2020.11.004}},
  doi          = {{10.1016/j.ijom.2020.11.004}},
  volume       = {{50}},
  year         = {{2021}},
}