A scoping review of how early-stage knee osteoarthritis has been defined
Liew, Jean W ; King, Lauren K ; Mahmoudian, Armaghan LU ; Wang, Qiuke ; Atkinson, Hayden F ; Flynn, David B ; Appleton, C Thomas ; Englund, Martin LU
; Haugen, Ida K
and Lohmander, L Stefan
LU
, et al.
(2023)
In Osteoarthritis and Cartilage
31(9).
p.1234-1241
- Abstract
BACKGROUND: Early-stage knee osteoarthritis (KOA) classification criteria will enable consistent identification and trial recruitment of individuals with knee osteoarthritis (OA) at an earlier stage of the disease when interventions may be more effective. Toward this goal, we identified how early-stage KOA has been defined in the literature.
METHODS: We performed a scoping literature review in PubMed, EMBASE, Cochrane, and Web of Science, including human studies where early-stage KOA was included as a study population or outcome. Extracted data included demographics, symptoms/history, examination, laboratory, imaging, performance-based measures, gross inspection/histopathologic domains, and the components of composite early-stage... (More)
BACKGROUND: Early-stage knee osteoarthritis (KOA) classification criteria will enable consistent identification and trial recruitment of individuals with knee osteoarthritis (OA) at an earlier stage of the disease when interventions may be more effective. Toward this goal, we identified how early-stage KOA has been defined in the literature.
METHODS: We performed a scoping literature review in PubMed, EMBASE, Cochrane, and Web of Science, including human studies where early-stage KOA was included as a study population or outcome. Extracted data included demographics, symptoms/history, examination, laboratory, imaging, performance-based measures, gross inspection/histopathologic domains, and the components of composite early-stage KOA definitions.
RESULTS: Of 6142 articles identified, 211 were included in data synthesis. An early-stage KOA definition was used for study inclusion in 194 studies, to define study outcomes in 11 studies, and in the context of new criteria development or validation in six studies. The element most often used to define early-stage KOA was Kellgren-Lawrence (KL) grade (151 studies, 72%), followed by symptoms (118 studies, 56%), and demographic characteristics (73 studies, 35%); 14 studies (6%) used previously developed early-stage KOA composite criteria. Among studies defining early-stage KOA radiographically, 52 studies defined early-stage KOA by KL grade alone; of these 52, 44 (85%) studies included individuals with KL grade 2 or higher in their definitions.
CONCLUSION: Early-stage KOA is variably defined in the published literature. Most studies included KL grades of 2 or higher within their definitions, which reflects established or later-stage OA. These findings underscore the need to develop and validate classification criteria for early-stage KOA.
(Less)
- author
- Liew, Jean W
; King, Lauren K
; Mahmoudian, Armaghan
LU
; Wang, Qiuke
; Atkinson, Hayden F
; Flynn, David B
; Appleton, C Thomas
; Englund, Martin
LU
; Haugen, Ida K
and Lohmander, L Stefan
LU
, et al. (More)
- Liew, Jean W
; King, Lauren K
; Mahmoudian, Armaghan
LU
; Wang, Qiuke
; Atkinson, Hayden F
; Flynn, David B
; Appleton, C Thomas
; Englund, Martin
LU
; Haugen, Ida K
; Lohmander, L Stefan
LU
; Runhaar, Jos
; Neogi, Tuhina
and Hawker, Gillian
(Less)
- author collaboration
- organization
- publishing date
- 2023-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Humans, Osteoarthritis, Knee/diagnostic imaging, Knee Joint/pathology
- in
- Osteoarthritis and Cartilage
- volume
- 31
- issue
- 9
- pages
- 1234 - 1241
- publisher
- Elsevier
- external identifiers
-
- scopus:85158086090
- pmid:37225053
- ISSN
- 1063-4584
- DOI
- 10.1016/j.joca.2023.04.015
- language
- English
- LU publication?
- yes
- additional info
- Copyright © 2023 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
- id
- 5698e148-827d-4445-85a4-45b24fedffcc
- date added to LUP
- 2023-10-06 20:30:05
- date last changed
- 2024-04-19 03:04:52
@article{5698e148-827d-4445-85a4-45b24fedffcc,
abstract = {{<p>BACKGROUND: Early-stage knee osteoarthritis (KOA) classification criteria will enable consistent identification and trial recruitment of individuals with knee osteoarthritis (OA) at an earlier stage of the disease when interventions may be more effective. Toward this goal, we identified how early-stage KOA has been defined in the literature.</p><p>METHODS: We performed a scoping literature review in PubMed, EMBASE, Cochrane, and Web of Science, including human studies where early-stage KOA was included as a study population or outcome. Extracted data included demographics, symptoms/history, examination, laboratory, imaging, performance-based measures, gross inspection/histopathologic domains, and the components of composite early-stage KOA definitions.</p><p>RESULTS: Of 6142 articles identified, 211 were included in data synthesis. An early-stage KOA definition was used for study inclusion in 194 studies, to define study outcomes in 11 studies, and in the context of new criteria development or validation in six studies. The element most often used to define early-stage KOA was Kellgren-Lawrence (KL) grade (151 studies, 72%), followed by symptoms (118 studies, 56%), and demographic characteristics (73 studies, 35%); 14 studies (6%) used previously developed early-stage KOA composite criteria. Among studies defining early-stage KOA radiographically, 52 studies defined early-stage KOA by KL grade alone; of these 52, 44 (85%) studies included individuals with KL grade 2 or higher in their definitions.</p><p>CONCLUSION: Early-stage KOA is variably defined in the published literature. Most studies included KL grades of 2 or higher within their definitions, which reflects established or later-stage OA. These findings underscore the need to develop and validate classification criteria for early-stage KOA.</p>}},
author = {{Liew, Jean W and King, Lauren K and Mahmoudian, Armaghan and Wang, Qiuke and Atkinson, Hayden F and Flynn, David B and Appleton, C Thomas and Englund, Martin and Haugen, Ida K and Lohmander, L Stefan and Runhaar, Jos and Neogi, Tuhina and Hawker, Gillian}},
issn = {{1063-4584}},
keywords = {{Humans; Osteoarthritis, Knee/diagnostic imaging; Knee Joint/pathology}},
language = {{eng}},
number = {{9}},
pages = {{1234--1241}},
publisher = {{Elsevier}},
series = {{Osteoarthritis and Cartilage}},
title = {{A scoping review of how early-stage knee osteoarthritis has been defined}},
url = {{http://dx.doi.org/10.1016/j.joca.2023.04.015}},
doi = {{10.1016/j.joca.2023.04.015}},
volume = {{31}},
year = {{2023}},
}