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Contact dermatitis caused by a new rubber compound detected in canvas shoes

Hulstaert, Eva; Bergendorff, Ola LU ; Persson, Christina LU ; Goossens, An; Gilissen, Liesbeth; Engfeldt, Malin LU ; Bruze, Magnus LU ; Schuttelaar, Marie L; Meijer, Joost M and Lapeere, Hilde (2017) In Contact Dermatitis
Abstract

BACKGROUND: In 2015 and 2016, female patients in Flanders consulted a dermatologist because they developed skin lesions after wearing a specific brand of canvas shoes.

OBJECTIVES: To identify the culprit allergen in the shoes.

METHODS: Eighteen young females aged 14-22 years presented with itching and erythematous to purple-coloured eczematous lesions on both feet. They were patch tested by 10 dermatologists with the European baseline series. Some patients underwent testing with additional series. Pieces of the shoe fabrics were tested in 11 of 18 patients. Chemical analysis of the shoe materials was performed. Finally, patients were tested with a thin-layer chromatogram of the shoe extracts and dilutions of the suspected... (More)

BACKGROUND: In 2015 and 2016, female patients in Flanders consulted a dermatologist because they developed skin lesions after wearing a specific brand of canvas shoes.

OBJECTIVES: To identify the culprit allergen in the shoes.

METHODS: Eighteen young females aged 14-22 years presented with itching and erythematous to purple-coloured eczematous lesions on both feet. They were patch tested by 10 dermatologists with the European baseline series. Some patients underwent testing with additional series. Pieces of the shoe fabrics were tested in 11 of 18 patients. Chemical analysis of the shoe materials was performed. Finally, patients were tested with a thin-layer chromatogram of the shoe extracts and dilutions of the suspected rubber compound.

RESULTS: All 18 patients showed positive reactions to thiuram mix. Ten of 11 patients reacted to a piece of shoe fabric. Chemical analysis showed the presence of dimethylthiocarbamylbenzothiazole sulfide (DMTBS). No thiurams were detected. Four patients tested with the chromatogram developed positive reactions to DMTBS. Positive reactions to low concentrations were observed in the 4 patients tested with a DMTBS dilution series; one patient reacted to 0.00001% in acetone.

CONCLUSIONS: DMTBS, the culprit allergen, is a component formed during rubber vulcanization that probably cross-reacts with the thiuram mix.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Journal Article
in
Contact Dermatitis
pages
6 pages
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • scopus:85038427166
  • wos:000418445900003
ISSN
0105-1873
DOI
10.1111/cod.12886
language
English
LU publication?
yes
id
56d74f81-ee4d-479f-8f5e-1fa11fbae49e
date added to LUP
2017-12-04 16:02:42
date last changed
2018-01-16 13:26:57
@article{56d74f81-ee4d-479f-8f5e-1fa11fbae49e,
  abstract     = {<p>BACKGROUND: In 2015 and 2016, female patients in Flanders consulted a dermatologist because they developed skin lesions after wearing a specific brand of canvas shoes.</p><p>OBJECTIVES: To identify the culprit allergen in the shoes.</p><p>METHODS: Eighteen young females aged 14-22 years presented with itching and erythematous to purple-coloured eczematous lesions on both feet. They were patch tested by 10 dermatologists with the European baseline series. Some patients underwent testing with additional series. Pieces of the shoe fabrics were tested in 11 of 18 patients. Chemical analysis of the shoe materials was performed. Finally, patients were tested with a thin-layer chromatogram of the shoe extracts and dilutions of the suspected rubber compound.</p><p>RESULTS: All 18 patients showed positive reactions to thiuram mix. Ten of 11 patients reacted to a piece of shoe fabric. Chemical analysis showed the presence of dimethylthiocarbamylbenzothiazole sulfide (DMTBS). No thiurams were detected. Four patients tested with the chromatogram developed positive reactions to DMTBS. Positive reactions to low concentrations were observed in the 4 patients tested with a DMTBS dilution series; one patient reacted to 0.00001% in acetone.</p><p>CONCLUSIONS: DMTBS, the culprit allergen, is a component formed during rubber vulcanization that probably cross-reacts with the thiuram mix.</p>},
  author       = {Hulstaert, Eva and Bergendorff, Ola and Persson, Christina and Goossens, An and Gilissen, Liesbeth and Engfeldt, Malin and Bruze, Magnus and Schuttelaar, Marie L and Meijer, Joost M and Lapeere, Hilde},
  issn         = {0105-1873},
  keyword      = {Journal Article},
  language     = {eng},
  month        = {12},
  pages        = {6},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Contact dermatitis caused by a new rubber compound detected in canvas shoes},
  url          = {http://dx.doi.org/10.1111/cod.12886},
  year         = {2017},
}