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Altered fractionation diminishes importance of tumor volume in oropharyngeal cancer : Subgroup analysis of ARTSCAN-trial

Adrian, Gabriel LU ; Gebre-Medhin, Maria LU ; Kjellén, Elisabeth LU ; Wieslander, Elinore LU ; Zackrisson, Björn and Nilsson, Per LU (2020) In Head and Neck 42(8). p.2099-2105
Abstract

BACKGROUND: A large tumor volume negatively impacts the outcome of radiation therapy (RT). Altered fractionation (AF) can improve local control (LC) compared with conventional fractionation (CF). The aim of the present study was to investigate if response to AF differs with tumor volume in oropharyngeal cancer.

METHODS: Three hundred and twenty four patients with oropharyngeal cancer treated in a randomized, phase III trial comparing CF (2 Gy/d, 5 d/wk, 7 weeks, total dose 68 Gy) to AF (1.1 Gy + 2 Gy/d, 5 d/wk, 4.5 weeks, total dose 68 Gy) were analyzed.

RESULTS: Tumor volume had less impact on LC for patients treated with AF. There was an interaction between tumor volume and fractionation schedule (P = .039). This... (More)

BACKGROUND: A large tumor volume negatively impacts the outcome of radiation therapy (RT). Altered fractionation (AF) can improve local control (LC) compared with conventional fractionation (CF). The aim of the present study was to investigate if response to AF differs with tumor volume in oropharyngeal cancer.

METHODS: Three hundred and twenty four patients with oropharyngeal cancer treated in a randomized, phase III trial comparing CF (2 Gy/d, 5 d/wk, 7 weeks, total dose 68 Gy) to AF (1.1 Gy + 2 Gy/d, 5 d/wk, 4.5 weeks, total dose 68 Gy) were analyzed.

RESULTS: Tumor volume had less impact on LC for patients treated with AF. There was an interaction between tumor volume and fractionation schedule (P = .039). This differential response was in favor of CF for small tumors and of AF for large tumors.

CONCLUSION: AF diminishes the importance of tumor volume for local tumor control in oropharyngeal cancer.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Head and Neck
volume
42
issue
8
pages
7 pages
publisher
John Wiley and Sons
external identifiers
  • scopus:85082038658
  • pmid:32196826
ISSN
1043-3074
DOI
10.1002/hed.26142
language
English
LU publication?
yes
additional info
© 2020 The Authors. Head & Neck published by Wiley Periodicals, Inc.
id
570b724f-ad77-4688-b089-b49c2108ca64
date added to LUP
2020-03-23 09:24:24
date last changed
2021-02-17 01:19:39
@article{570b724f-ad77-4688-b089-b49c2108ca64,
  abstract     = {<p>BACKGROUND: A large tumor volume negatively impacts the outcome of radiation therapy (RT). Altered fractionation (AF) can improve local control (LC) compared with conventional fractionation (CF). The aim of the present study was to investigate if response to AF differs with tumor volume in oropharyngeal cancer.</p><p>METHODS: Three hundred and twenty four patients with oropharyngeal cancer treated in a randomized, phase III trial comparing CF (2 Gy/d, 5 d/wk, 7 weeks, total dose 68 Gy) to AF (1.1 Gy + 2 Gy/d, 5 d/wk, 4.5 weeks, total dose 68 Gy) were analyzed.</p><p>RESULTS: Tumor volume had less impact on LC for patients treated with AF. There was an interaction between tumor volume and fractionation schedule (P = .039). This differential response was in favor of CF for small tumors and of AF for large tumors.</p><p>CONCLUSION: AF diminishes the importance of tumor volume for local tumor control in oropharyngeal cancer.</p>},
  author       = {Adrian, Gabriel and Gebre-Medhin, Maria and Kjellén, Elisabeth and Wieslander, Elinore and Zackrisson, Björn and Nilsson, Per},
  issn         = {1043-3074},
  language     = {eng},
  number       = {8},
  pages        = {2099--2105},
  publisher    = {John Wiley and Sons},
  series       = {Head and Neck},
  title        = {Altered fractionation diminishes importance of tumor volume in oropharyngeal cancer : Subgroup analysis of ARTSCAN-trial},
  url          = {http://dx.doi.org/10.1002/hed.26142},
  doi          = {10.1002/hed.26142},
  volume       = {42},
  year         = {2020},
}