Characterization of Chemical Exchange Using Residual Dipolar Coupling
(2007) In Journal of the American Chemical Society 129(44). p.13396-13396- Abstract
- Abstract in Undetermined
NMR line shape analysis and relaxation dispersion measurements for N,N-dimethyltrichloroacetamide (DMTCA) weakly aligned using poly-γ-benzyl-l-glutamate, which forms a lyotropic nematic phase when dissolved in chloroform, were used to characterize chemical exchange kinetics for the rotation around the C−N amide bond. At low temperatures (<312 K), slow-exchange 1H-coupled 13C NMR spectra show two resolved 13C methyl quartets with different residual dipolar coupling constants (RDCs). At high temperatures (>312 K), a single population-averaged 13C methyl quartet is observed; in this regime, the differences in RDCs contribute to differential line broadening of the quartet components. Self-consistent... (More) - Abstract in Undetermined
NMR line shape analysis and relaxation dispersion measurements for N,N-dimethyltrichloroacetamide (DMTCA) weakly aligned using poly-γ-benzyl-l-glutamate, which forms a lyotropic nematic phase when dissolved in chloroform, were used to characterize chemical exchange kinetics for the rotation around the C−N amide bond. At low temperatures (<312 K), slow-exchange 1H-coupled 13C NMR spectra show two resolved 13C methyl quartets with different residual dipolar coupling constants (RDCs). At high temperatures (>312 K), a single population-averaged 13C methyl quartet is observed; in this regime, the differences in RDCs contribute to differential line broadening of the quartet components. Self-consistent measurements of the difference in RDCs are obtained from both line shape and relaxation dispersion techniques. The results show that NMR spectroscopy of weakly aligned molecules allows complete characterization of chemical exchange processes using RDCs, even if exchange broadening is absent in isotropic samples. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/572532
- author
- Igumenova, Tatyana I.
; Brath, Ulrika
LU
; Akke, Mikael
LU
and Palmer, Arthur G.
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of the American Chemical Society
- volume
- 129
- issue
- 44
- pages
- 13396 - 13396
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000250819200019
- scopus:35948981100
- ISSN
- 1520-5126
- DOI
- 10.1021/ja0761636
- language
- English
- LU publication?
- yes
- id
- 2e71238f-f54c-444a-b28e-5a900ff4e762 (old id 572532)
- date added to LUP
- 2016-04-01 16:52:45
- date last changed
- 2024-06-11 11:09:53
@article{2e71238f-f54c-444a-b28e-5a900ff4e762, abstract = {{Abstract in Undetermined<br> NMR line shape analysis and relaxation dispersion measurements for N,N-dimethyltrichloroacetamide (DMTCA) weakly aligned using poly-γ-benzyl-l-glutamate, which forms a lyotropic nematic phase when dissolved in chloroform, were used to characterize chemical exchange kinetics for the rotation around the C−N amide bond. At low temperatures (<312 K), slow-exchange 1H-coupled 13C NMR spectra show two resolved 13C methyl quartets with different residual dipolar coupling constants (RDCs). At high temperatures (>312 K), a single population-averaged 13C methyl quartet is observed; in this regime, the differences in RDCs contribute to differential line broadening of the quartet components. Self-consistent measurements of the difference in RDCs are obtained from both line shape and relaxation dispersion techniques. The results show that NMR spectroscopy of weakly aligned molecules allows complete characterization of chemical exchange processes using RDCs, even if exchange broadening is absent in isotropic samples.}}, author = {{Igumenova, Tatyana I. and Brath, Ulrika and Akke, Mikael and Palmer, Arthur G.}}, issn = {{1520-5126}}, language = {{eng}}, number = {{44}}, pages = {{13396--13396}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Journal of the American Chemical Society}}, title = {{Characterization of Chemical Exchange Using Residual Dipolar Coupling}}, url = {{http://dx.doi.org/10.1021/ja0761636}}, doi = {{10.1021/ja0761636}}, volume = {{129}}, year = {{2007}}, }