Small-bowel capsule endoscopy in patients with Meckel's diverticulum : clinical features, diagnostic workup, and findings. A European multicenter I-CARE study
(2023) In Gastrointestinal Endoscopy 97(5). p.3-926- Abstract
Background and Aims: Meckel's diverticulum (MD) may remain silent or be associated with adverse events such as GI bleeding. The main aim of this study was to evaluate indicative small-bowel capsule endoscopy (SBCE) findings, and the secondary aim was to describe clinical presentation in patients with MD. Methods: This retrospective European multicenter study included patients with MD undergoing SBCE from 2001 until July 2021. Results: Sixty-nine patients with a confirmed MD were included. Median age was 32 years with a male-to-female ratio of approximately 3:1. GI bleeding or iron-deficiency anemia was present in nearly all patients. Mean hemoglobin was 7.63 ± 1.8 g/dL with a transfusion requirement of 52.2%. Typical capsule endoscopy... (More)
Background and Aims: Meckel's diverticulum (MD) may remain silent or be associated with adverse events such as GI bleeding. The main aim of this study was to evaluate indicative small-bowel capsule endoscopy (SBCE) findings, and the secondary aim was to describe clinical presentation in patients with MD. Methods: This retrospective European multicenter study included patients with MD undergoing SBCE from 2001 until July 2021. Results: Sixty-nine patients with a confirmed MD were included. Median age was 32 years with a male-to-female ratio of approximately 3:1. GI bleeding or iron-deficiency anemia was present in nearly all patients. Mean hemoglobin was 7.63 ± 1.8 g/dL with a transfusion requirement of 52.2%. Typical capsule endoscopy (CE) findings were double lumen (n = 49 [71%]), visible entrance into the MD (n = 49 [71%]), mucosal webs (n = 30 [43.5%]), and bulges (n = 19 [27.5%]). Two or more of these findings were seen in 48 patients (69.6%). Ulcers were detected in 52.2% of patients (n = 36). In 63.8% of patients (n = 44), a combination of double lumen and visible entrance into the MD was evident, additionally revealing ulcers in 39.1% (n = 27). Mean percent SB (small bowel) transit time for the first indicative image of MD was 57% of the total SB transit time. Conclusions: Diagnosis of MD is rare and sometimes challenging, and a preoperative criterion standard does not exist. In SBCE, the most frequent findings were double-lumen sign and visible diverticular entrance, sometimes together with ulcers.
(Less)
- author
- contributor
- Toth, E. LU
- author collaboration
- organization
- publishing date
- 2023-05
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Gastrointestinal Endoscopy
- volume
- 97
- issue
- 5
- pages
- 3 - 926
- publisher
- Elsevier
- external identifiers
-
- pmid:36572128
- scopus:85150270355
- ISSN
- 0016-5107
- DOI
- 10.1016/j.gie.2022.12.014
- language
- English
- LU publication?
- yes
- id
- 574a5fe8-2da7-487d-abc3-0cb551ac798d
- date added to LUP
- 2023-07-04 12:00:55
- date last changed
- 2024-04-19 23:13:20
@article{574a5fe8-2da7-487d-abc3-0cb551ac798d,
abstract = {{<p>Background and Aims: Meckel's diverticulum (MD) may remain silent or be associated with adverse events such as GI bleeding. The main aim of this study was to evaluate indicative small-bowel capsule endoscopy (SBCE) findings, and the secondary aim was to describe clinical presentation in patients with MD. Methods: This retrospective European multicenter study included patients with MD undergoing SBCE from 2001 until July 2021. Results: Sixty-nine patients with a confirmed MD were included. Median age was 32 years with a male-to-female ratio of approximately 3:1. GI bleeding or iron-deficiency anemia was present in nearly all patients. Mean hemoglobin was 7.63 ± 1.8 g/dL with a transfusion requirement of 52.2%. Typical capsule endoscopy (CE) findings were double lumen (n = 49 [71%]), visible entrance into the MD (n = 49 [71%]), mucosal webs (n = 30 [43.5%]), and bulges (n = 19 [27.5%]). Two or more of these findings were seen in 48 patients (69.6%). Ulcers were detected in 52.2% of patients (n = 36). In 63.8% of patients (n = 44), a combination of double lumen and visible entrance into the MD was evident, additionally revealing ulcers in 39.1% (n = 27). Mean percent SB (small bowel) transit time for the first indicative image of MD was 57% of the total SB transit time. Conclusions: Diagnosis of MD is rare and sometimes challenging, and a preoperative criterion standard does not exist. In SBCE, the most frequent findings were double-lumen sign and visible diverticular entrance, sometimes together with ulcers.</p>}},
author = {{Baltes, Peter and Dray, Xavier and Riccioni, Maria Elena and Pérez-Cuadrado-Robles, Enrique and Fedorov, Evgeny and Wiedbrauck, Felix and Chetcuti Zammit, Stefania and Cadoni, Sergio and Bruno, Mauro and Rondonotti, Emanuele and Johansson, Gabriele Wurm and Mussetto, Alessandro and Beaumont, Hanneke and Perrod, Guillaume and McNamara, Deirdre and Plevris, John and Spada, Cristiano and Pinho, Rolando and Rosa, Bruno and Hervas, Nerea and Leenhardt, Romain and Marmo, Clelia and Esteban-Delgado, Pilar and Ivanova, Ekaterina and Keuchel, Martin}},
issn = {{0016-5107}},
language = {{eng}},
number = {{5}},
pages = {{3--926}},
publisher = {{Elsevier}},
series = {{Gastrointestinal Endoscopy}},
title = {{Small-bowel capsule endoscopy in patients with Meckel's diverticulum : clinical features, diagnostic workup, and findings. A European multicenter I-CARE study}},
url = {{http://dx.doi.org/10.1016/j.gie.2022.12.014}},
doi = {{10.1016/j.gie.2022.12.014}},
volume = {{97}},
year = {{2023}},
}