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Recent advances of PET imaging in clinical radiation oncology

Unterrainer, M. ; Eze, C. ; Ilhan, H. ; Marschner, S. ; Roengvoraphoj, O. ; Schmidt-Hegemann, N. S. ; Walter, F. ; Kunz, W. G. ; Rosenschöld, P. Munck Af LU orcid and Jeraj, R. , et al. (2020) In Radiation Oncology 15(1).
Abstract

Radiotherapy and radiation oncology play a key role in the clinical management of patients suffering from oncological diseases. In clinical routine, anatomic imaging such as contrast-enhanced CT and MRI are widely available and are usually used to improve the target volume delineation for subsequent radiotherapy. Moreover, these modalities are also used for treatment monitoring after radiotherapy. However, some diagnostic questions cannot be sufficiently addressed by the mere use standard morphological imaging. Therefore, positron emission tomography (PET) imaging gains increasing clinical significance in the management of oncological patients undergoing radiotherapy, as PET allows the visualization and quantification of tumoral... (More)

Radiotherapy and radiation oncology play a key role in the clinical management of patients suffering from oncological diseases. In clinical routine, anatomic imaging such as contrast-enhanced CT and MRI are widely available and are usually used to improve the target volume delineation for subsequent radiotherapy. Moreover, these modalities are also used for treatment monitoring after radiotherapy. However, some diagnostic questions cannot be sufficiently addressed by the mere use standard morphological imaging. Therefore, positron emission tomography (PET) imaging gains increasing clinical significance in the management of oncological patients undergoing radiotherapy, as PET allows the visualization and quantification of tumoral features on a molecular level beyond the mere morphological extent shown by conventional imaging, such as tumor metabolism or receptor expression. The tumor metabolism or receptor expression information derived from PET can be used as tool for visualization of tumor extent, for assessing response during and after therapy, for prediction of patterns of failure and for definition of the volume in need of dose-escalation. This review focuses on recent and current advances of PET imaging within the field of clinical radiotherapy / radiation oncology in several oncological entities (neuro-oncology, head & neck cancer, lung cancer, gastrointestinal tumors and prostate cancer) with particular emphasis on radiotherapy planning, response assessment after radiotherapy and prognostication.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
GI malignancies, Head & neck cancer, Lung cancer, Neuro-oncology, PET, Prostate cancer, Radiation oncology
in
Radiation Oncology
volume
15
issue
1
article number
88
publisher
BioMed Central (BMC)
external identifiers
  • pmid:32317029
  • scopus:85083871998
ISSN
1748-717X
DOI
10.1186/s13014-020-01519-1
language
English
LU publication?
yes
id
57c8b4d2-3a1c-48b2-928d-26b2380fbf75
date added to LUP
2020-05-20 09:56:05
date last changed
2024-04-17 09:27:19
@article{57c8b4d2-3a1c-48b2-928d-26b2380fbf75,
  abstract     = {{<p>Radiotherapy and radiation oncology play a key role in the clinical management of patients suffering from oncological diseases. In clinical routine, anatomic imaging such as contrast-enhanced CT and MRI are widely available and are usually used to improve the target volume delineation for subsequent radiotherapy. Moreover, these modalities are also used for treatment monitoring after radiotherapy. However, some diagnostic questions cannot be sufficiently addressed by the mere use standard morphological imaging. Therefore, positron emission tomography (PET) imaging gains increasing clinical significance in the management of oncological patients undergoing radiotherapy, as PET allows the visualization and quantification of tumoral features on a molecular level beyond the mere morphological extent shown by conventional imaging, such as tumor metabolism or receptor expression. The tumor metabolism or receptor expression information derived from PET can be used as tool for visualization of tumor extent, for assessing response during and after therapy, for prediction of patterns of failure and for definition of the volume in need of dose-escalation. This review focuses on recent and current advances of PET imaging within the field of clinical radiotherapy / radiation oncology in several oncological entities (neuro-oncology, head &amp; neck cancer, lung cancer, gastrointestinal tumors and prostate cancer) with particular emphasis on radiotherapy planning, response assessment after radiotherapy and prognostication.</p>}},
  author       = {{Unterrainer, M. and Eze, C. and Ilhan, H. and Marschner, S. and Roengvoraphoj, O. and Schmidt-Hegemann, N. S. and Walter, F. and Kunz, W. G. and Rosenschöld, P. Munck Af and Jeraj, R. and Albert, N. L. and Grosu, A. L. and Niyazi, M. and Bartenstein, P. and Belka, C.}},
  issn         = {{1748-717X}},
  keywords     = {{GI malignancies; Head & neck cancer; Lung cancer; Neuro-oncology; PET; Prostate cancer; Radiation oncology}},
  language     = {{eng}},
  month        = {{04}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Radiation Oncology}},
  title        = {{Recent advances of PET imaging in clinical radiation oncology}},
  url          = {{http://dx.doi.org/10.1186/s13014-020-01519-1}},
  doi          = {{10.1186/s13014-020-01519-1}},
  volume       = {{15}},
  year         = {{2020}},
}