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Elevated levels of IL-6 and IGFBP-1 predict low serum IGF-1 levels during continuous infusion of rhIGF-1/rhIGFBP-3 in extremely preterm infants

Klevebro, Susanna ; Hellgren, Gunnel ; Hansen-Pupp, Ingrid LU ; Wackernagel, Dirk ; Hallberg, Boubou ; Borg, Jan ; Pivodic, Aldina ; Smith, Lois ; Ley, David LU and Hellström, Ann LU (2020) In Growth Hormone and IGF Research 50. p.1-8
Abstract

Objective: Steady state insulin-like growth factor-1 (IGF-1) levels vary significantly during continuous intravenous infusion of recombinant human insulin-like growth factor-1/recombinant human insulin-like growth factor binding protein-3 (rhIGF-1/rhIGFBP-3) in the first weeks of life in extremely preterm infants. We evaluated interleukin-6 (IL-6) and insulin-like growth factor binding protein-1 (IGFBP-1) levels as predictors of low IGF-1 levels. Methods: Nineteen extremely preterm infants were enrolled in a trial, 9 received rhIGF-1/rhIGFBP-3 and 10 received standard neonatal care. Blood samples were analyzed daily for IGF-1, IL-6 and IGFBP-1 during intervention with rhIGF-1/rhIGFBP-3. Results: Thirty seven percent of IGF-1 values... (More)

Objective: Steady state insulin-like growth factor-1 (IGF-1) levels vary significantly during continuous intravenous infusion of recombinant human insulin-like growth factor-1/recombinant human insulin-like growth factor binding protein-3 (rhIGF-1/rhIGFBP-3) in the first weeks of life in extremely preterm infants. We evaluated interleukin-6 (IL-6) and insulin-like growth factor binding protein-1 (IGFBP-1) levels as predictors of low IGF-1 levels. Methods: Nineteen extremely preterm infants were enrolled in a trial, 9 received rhIGF-1/rhIGFBP-3 and 10 received standard neonatal care. Blood samples were analyzed daily for IGF-1, IL-6 and IGFBP-1 during intervention with rhIGF-1/rhIGFBP-3. Results: Thirty seven percent of IGF-1 values during active treatment were <20 μg/L. Among treated infants, higher levels of IL-6, one and two days before sampled IGF-1, were associated with IGF-1 < 20 μg/L, gestational age adjusted OR 1.30 (95% CI 1.03–1.63), p = .026, and 1.57 (95% CI 1.26–1.97), p < .001 respectively. Higher levels of IGFBP-1 one day before sampled IGF-1 was also associated with IGF-1 < 20 μg/L, gestational age adjusted OR 1.74 (95% CI 1.19–2.53), p = .004. Conclusion: In preterm infants receiving continuous infusion of rhIGF-1/rhIGFBP-3, higher levels of IL-6 and IGFBP-1 preceded lower levels of circulating IGF-1. These findings demonstrate a need to further evaluate if inflammation and/or infection suppress serum IGF-1 levels. The trial is registered at ClinicalTrials.gov (NCT01096784).

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
IGF-1, IGFBP-1, IL-6, Inflammation, Preterm infants, rhIGF-1/rhIGFBP-3
in
Growth Hormone and IGF Research
volume
50
pages
8 pages
publisher
Elsevier
external identifiers
  • pmid:31756675
  • scopus:85075055406
ISSN
1096-6374
DOI
10.1016/j.ghir.2019.11.001
language
English
LU publication?
yes
id
5813cedc-5a83-4d35-8826-9cd87ed2d018
date added to LUP
2019-11-28 08:04:02
date last changed
2020-01-13 02:33:05
@article{5813cedc-5a83-4d35-8826-9cd87ed2d018,
  abstract     = {<p>Objective: Steady state insulin-like growth factor-1 (IGF-1) levels vary significantly during continuous intravenous infusion of recombinant human insulin-like growth factor-1/recombinant human insulin-like growth factor binding protein-3 (rhIGF-1/rhIGFBP-3) in the first weeks of life in extremely preterm infants. We evaluated interleukin-6 (IL-6) and insulin-like growth factor binding protein-1 (IGFBP-1) levels as predictors of low IGF-1 levels. Methods: Nineteen extremely preterm infants were enrolled in a trial, 9 received rhIGF-1/rhIGFBP-3 and 10 received standard neonatal care. Blood samples were analyzed daily for IGF-1, IL-6 and IGFBP-1 during intervention with rhIGF-1/rhIGFBP-3. Results: Thirty seven percent of IGF-1 values during active treatment were &lt;20 μg/L. Among treated infants, higher levels of IL-6, one and two days before sampled IGF-1, were associated with IGF-1 &lt; 20 μg/L, gestational age adjusted OR 1.30 (95% CI 1.03–1.63), p = .026, and 1.57 (95% CI 1.26–1.97), p &lt; .001 respectively. Higher levels of IGFBP-1 one day before sampled IGF-1 was also associated with IGF-1 &lt; 20 μg/L, gestational age adjusted OR 1.74 (95% CI 1.19–2.53), p = .004. Conclusion: In preterm infants receiving continuous infusion of rhIGF-1/rhIGFBP-3, higher levels of IL-6 and IGFBP-1 preceded lower levels of circulating IGF-1. These findings demonstrate a need to further evaluate if inflammation and/or infection suppress serum IGF-1 levels. The trial is registered at ClinicalTrials.gov (NCT01096784).</p>},
  author       = {Klevebro, Susanna and Hellgren, Gunnel and Hansen-Pupp, Ingrid and Wackernagel, Dirk and Hallberg, Boubou and Borg, Jan and Pivodic, Aldina and Smith, Lois and Ley, David and Hellström, Ann},
  issn         = {1096-6374},
  language     = {eng},
  pages        = {1--8},
  publisher    = {Elsevier},
  series       = {Growth Hormone and IGF Research},
  title        = {Elevated levels of IL-6 and IGFBP-1 predict low serum IGF-1 levels during continuous infusion of rhIGF-1/rhIGFBP-3 in extremely preterm infants},
  url          = {http://dx.doi.org/10.1016/j.ghir.2019.11.001},
  doi          = {10.1016/j.ghir.2019.11.001},
  volume       = {50},
  year         = {2020},
}