Overweight in relation to tumour size and axillary lymph node involvement in postmenopausal breast cancer patients-differences between women invited to vs. not invited to mammography in a randomized screening trial.
(2009) In Cancer Epidemiology 33(1). p.41532-41532- Abstract
- OBJECTIVES: Overweight is associated with advanced stage at diagnosis in breast cancer patients. This could be explained by specific tumour characteristics or tumour promoting factors in the obese, but a diagnostic delay could also be of importance. Mammographic screening has caused a change towards diagnosis of less advanced tumours. This study investigates invitation to mammographic screening and the association between overweight and tumour size/axillary lymph node involvement at breast cancer diagnosis in postmenopausal women. METHODS: In 1976 a randomized mammographic screening trial, inviting 50% of all women aged 45-69 was set up in Malmö, Sweden. The present analysis examined overweight (body mass index >or=25) as a determinant... (More)
- OBJECTIVES: Overweight is associated with advanced stage at diagnosis in breast cancer patients. This could be explained by specific tumour characteristics or tumour promoting factors in the obese, but a diagnostic delay could also be of importance. Mammographic screening has caused a change towards diagnosis of less advanced tumours. This study investigates invitation to mammographic screening and the association between overweight and tumour size/axillary lymph node involvement at breast cancer diagnosis in postmenopausal women. METHODS: In 1976 a randomized mammographic screening trial, inviting 50% of all women aged 45-69 was set up in Malmö, Sweden. The present analysis examined overweight (body mass index >or=25) as a determinant for large tumours (>20mm) and axillary lymph node involvement in postmenopausal women. These associations were studied separately in patients diagnosed prior to the mammographic screening trial, in invited women and in non-invited subjects (controls). In all, 2478 postmenopausal women were diagnosed with invasive breast cancer in these groups between 1961 and 1991. Logistic regression analysis allowed adjustment for other potential determinants of tumours size and axillary lymph node involvement. RESULTS: In women diagnosed before the onset of the screening trial and in women not invited to mammography in the trial (controls), overweight was positively associated with large tumour size and axillary node involvement. There was no statistically significant association between overweight and these factors in women invited to mammographic screening. CONCLUSION: Invitation to mammographic screening may be particularly important for overweight postmenopausal women in order to detect breast tumours early. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1469775
- author
- Olsson, Åsa LU ; Garne, Jens Peter ; Tengrup, Ingrid LU ; Zackrisson, Sophia LU and Manjer, Jonas LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cancer Epidemiology
- volume
- 33
- issue
- 1
- pages
- 41532 - 41532
- publisher
- Elsevier
- external identifiers
-
- wos:000269846400003
- pmid:19679041
- scopus:67649844032
- pmid:19679041
- ISSN
- 1877-7821
- DOI
- 10.1016/j.canep.2009.04.008
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Cardio-vascular Epidemiology (013241610), Emergency medicine/Medicine/Surgery (013240200), Surgery Research Unit (013242220)
- id
- 581ac91c-56ec-4520-af24-e8f07a38841a (old id 1469775)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19679041?dopt=Abstract
- date added to LUP
- 2016-04-04 08:25:46
- date last changed
- 2022-01-29 03:26:47
@article{581ac91c-56ec-4520-af24-e8f07a38841a,
abstract = {{OBJECTIVES: Overweight is associated with advanced stage at diagnosis in breast cancer patients. This could be explained by specific tumour characteristics or tumour promoting factors in the obese, but a diagnostic delay could also be of importance. Mammographic screening has caused a change towards diagnosis of less advanced tumours. This study investigates invitation to mammographic screening and the association between overweight and tumour size/axillary lymph node involvement at breast cancer diagnosis in postmenopausal women. METHODS: In 1976 a randomized mammographic screening trial, inviting 50% of all women aged 45-69 was set up in Malmö, Sweden. The present analysis examined overweight (body mass index >or=25) as a determinant for large tumours (>20mm) and axillary lymph node involvement in postmenopausal women. These associations were studied separately in patients diagnosed prior to the mammographic screening trial, in invited women and in non-invited subjects (controls). In all, 2478 postmenopausal women were diagnosed with invasive breast cancer in these groups between 1961 and 1991. Logistic regression analysis allowed adjustment for other potential determinants of tumours size and axillary lymph node involvement. RESULTS: In women diagnosed before the onset of the screening trial and in women not invited to mammography in the trial (controls), overweight was positively associated with large tumour size and axillary node involvement. There was no statistically significant association between overweight and these factors in women invited to mammographic screening. CONCLUSION: Invitation to mammographic screening may be particularly important for overweight postmenopausal women in order to detect breast tumours early.}},
author = {{Olsson, Åsa and Garne, Jens Peter and Tengrup, Ingrid and Zackrisson, Sophia and Manjer, Jonas}},
issn = {{1877-7821}},
language = {{eng}},
number = {{1}},
pages = {{41532--41532}},
publisher = {{Elsevier}},
series = {{Cancer Epidemiology}},
title = {{Overweight in relation to tumour size and axillary lymph node involvement in postmenopausal breast cancer patients-differences between women invited to vs. not invited to mammography in a randomized screening trial.}},
url = {{http://dx.doi.org/10.1016/j.canep.2009.04.008}},
doi = {{10.1016/j.canep.2009.04.008}},
volume = {{33}},
year = {{2009}},
}