Carcinoma in situ of the breast: correlation of histopathology to immunohistochemical markers and DNA ploidy
(2000) In Breast Cancer Research and Treatment 60(3). p.219-226- Abstract
- In a consecutive and unselected series of 178 cases of carcinoma in situ of the breast (CIS), comprising both ductal (DCIS) and lobular type (LCIS), and a series of 48 cases of invasive carcinoma (IC) with predominance of DCIS, the association between histopathology, immunohistochemical markers (ER, PgR, MIB-1, c-erbB-2, and p53), and DNA ploidy was investigated, in order to discriminate biologically different groups. In DCIS, significant correlation was shown between large nuclear size and comedonecrosis, both of which showed also strong association to DNA aneuploidy, high proliferation activity, low steroid receptor content, and overexpression of c-erbB-2 and p53 factors that may indicate an aggressive behavior. Small nuclear CIS,... (More)
- In a consecutive and unselected series of 178 cases of carcinoma in situ of the breast (CIS), comprising both ductal (DCIS) and lobular type (LCIS), and a series of 48 cases of invasive carcinoma (IC) with predominance of DCIS, the association between histopathology, immunohistochemical markers (ER, PgR, MIB-1, c-erbB-2, and p53), and DNA ploidy was investigated, in order to discriminate biologically different groups. In DCIS, significant correlation was shown between large nuclear size and comedonecrosis, both of which showed also strong association to DNA aneuploidy, high proliferation activity, low steroid receptor content, and overexpression of c-erbB-2 and p53 factors that may indicate an aggressive behavior. Small nuclear CIS, whether LCIS or DCIS, on the contrary, were DNA diploid with low proliferation, and no cases showed overexpression of c-erbB-2 and p53. Heterogeneity with respect to the investigated parameters was also a frequent finding that may reflect a development complexity. In IC, comparison of the DCIS and the invasive component showed similar patterns. No significant differences were shown between DCIS without and with invasion. This may indicate that none of the investigated parameters on its own are essential for the event of invasion. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1116614
- author
- Ottesen, G L ; Christensen, I J ; Larsen, J K ; Larsen, J ; Baldetorp, Bo LU ; Linden, Thomas ; Hansen, B and Andersen, J
- organization
- publishing date
- 2000
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- DNA ploidy, carcinoma in situ, breast, histopathology, immunohistochemistry, invasive carcinoma
- in
- Breast Cancer Research and Treatment
- volume
- 60
- issue
- 3
- pages
- 219 - 226
- publisher
- Springer
- external identifiers
-
- pmid:10930109
- scopus:0033935483
- ISSN
- 1573-7217
- DOI
- 10.1023/A:1006453420088
- language
- English
- LU publication?
- yes
- id
- 581ed26c-29ce-4df6-8b3c-a56b49da4c5f (old id 1116614)
- date added to LUP
- 2016-04-01 15:43:12
- date last changed
- 2022-01-28 06:44:00
@article{581ed26c-29ce-4df6-8b3c-a56b49da4c5f,
abstract = {{In a consecutive and unselected series of 178 cases of carcinoma in situ of the breast (CIS), comprising both ductal (DCIS) and lobular type (LCIS), and a series of 48 cases of invasive carcinoma (IC) with predominance of DCIS, the association between histopathology, immunohistochemical markers (ER, PgR, MIB-1, c-erbB-2, and p53), and DNA ploidy was investigated, in order to discriminate biologically different groups. In DCIS, significant correlation was shown between large nuclear size and comedonecrosis, both of which showed also strong association to DNA aneuploidy, high proliferation activity, low steroid receptor content, and overexpression of c-erbB-2 and p53 factors that may indicate an aggressive behavior. Small nuclear CIS, whether LCIS or DCIS, on the contrary, were DNA diploid with low proliferation, and no cases showed overexpression of c-erbB-2 and p53. Heterogeneity with respect to the investigated parameters was also a frequent finding that may reflect a development complexity. In IC, comparison of the DCIS and the invasive component showed similar patterns. No significant differences were shown between DCIS without and with invasion. This may indicate that none of the investigated parameters on its own are essential for the event of invasion.}},
author = {{Ottesen, G L and Christensen, I J and Larsen, J K and Larsen, J and Baldetorp, Bo and Linden, Thomas and Hansen, B and Andersen, J}},
issn = {{1573-7217}},
keywords = {{DNA ploidy; carcinoma in situ; breast; histopathology; immunohistochemistry; invasive carcinoma}},
language = {{eng}},
number = {{3}},
pages = {{219--226}},
publisher = {{Springer}},
series = {{Breast Cancer Research and Treatment}},
title = {{Carcinoma in situ of the breast: correlation of histopathology to immunohistochemical markers and DNA ploidy}},
url = {{http://dx.doi.org/10.1023/A:1006453420088}},
doi = {{10.1023/A:1006453420088}},
volume = {{60}},
year = {{2000}},
}