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Identification and Cytotoxic Evaluation of Pregnane Saponins from the Twigs and Leaves of Dregea volubilis

Diep Vu, Thi ; Khoa Nguyen, Manh ; Thu Nguyen, Thi ; Hien Tran, Thi LU ; Tuan Nguyen, Hoang and Ha Do, Thi (2023) In Chemistry and Biodiversity
Abstract

Four new polyhydroxy pregnane glycosides, named volubilosides G−K (3, 5–7), along with three known secondary metabolites, dregeoside Da1 (1), dregeoside Ka1 (2), and volubiloside E (4) were isolated from the twigs and leaves of Dregea volubilis (DV). The chemical structures of these compounds (1–7) were elucidated using spectroscopic techniques (1D and 2D NMR and HR-ESI-MS analyses) and compared with those in the published literature. Compounds (1–7) were evaluated for cytotoxicity against eight cancer cell lines (MB49, K562, MKN-7, HT29, A549, MCF-7, MDA-MB-231, and HepG2), revealing varying levels of cytotoxic effects with IC50 values ranging from 4.29 to 21.05 μM. The results indicated that compounds... (More)

Four new polyhydroxy pregnane glycosides, named volubilosides G−K (3, 5–7), along with three known secondary metabolites, dregeoside Da1 (1), dregeoside Ka1 (2), and volubiloside E (4) were isolated from the twigs and leaves of Dregea volubilis (DV). The chemical structures of these compounds (1–7) were elucidated using spectroscopic techniques (1D and 2D NMR and HR-ESI-MS analyses) and compared with those in the published literature. Compounds (1–7) were evaluated for cytotoxicity against eight cancer cell lines (MB49, K562, MKN-7, HT29, A549, MCF-7, MDA-MB-231, and HepG2), revealing varying levels of cytotoxic effects with IC50 values ranging from 4.29 to 21.05 μM. The results indicated that compounds 1–7 may serve as potential lead compounds for the discovery and development of novel anti-cancer drugs.

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author
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organization
publishing date
type
Contribution to journal
publication status
in press
subject
keywords
cancer cell lines, cytotoxicity, Dregea volubilis, pregnane glycosides
in
Chemistry and Biodiversity
publisher
Verlag Helvetica Chimica Acta
external identifiers
  • pmid:38018332
  • scopus:85179305557
ISSN
1612-1872
DOI
10.1002/cbdv.202301417
language
English
LU publication?
yes
id
5842eae6-7a2f-48f5-a7a8-4acee2d345bf
date added to LUP
2024-01-11 15:10:40
date last changed
2024-04-12 09:01:57
@article{5842eae6-7a2f-48f5-a7a8-4acee2d345bf,
  abstract     = {{<p>Four new polyhydroxy pregnane glycosides, named volubilosides G−K (3, 5–7), along with three known secondary metabolites, dregeoside D<sub>a1</sub> (1), dregeoside K<sub>a1</sub> (2), and volubiloside E (4) were isolated from the twigs and leaves of Dregea volubilis (DV). The chemical structures of these compounds (1–7) were elucidated using spectroscopic techniques (1D and 2D NMR and HR-ESI-MS analyses) and compared with those in the published literature. Compounds (1–7) were evaluated for cytotoxicity against eight cancer cell lines (MB49, K562, MKN-7, HT29, A549, MCF-7, MDA-MB-231, and HepG2), revealing varying levels of cytotoxic effects with IC<sub>50</sub> values ranging from 4.29 to 21.05 μM. The results indicated that compounds 1–7 may serve as potential lead compounds for the discovery and development of novel anti-cancer drugs.</p>}},
  author       = {{Diep Vu, Thi and Khoa Nguyen, Manh and Thu Nguyen, Thi and Hien Tran, Thi and Tuan Nguyen, Hoang and Ha Do, Thi}},
  issn         = {{1612-1872}},
  keywords     = {{cancer cell lines; cytotoxicity; Dregea volubilis; pregnane glycosides}},
  language     = {{eng}},
  publisher    = {{Verlag Helvetica Chimica Acta}},
  series       = {{Chemistry and Biodiversity}},
  title        = {{Identification and Cytotoxic Evaluation of Pregnane Saponins from the Twigs and Leaves of Dregea volubilis}},
  url          = {{http://dx.doi.org/10.1002/cbdv.202301417}},
  doi          = {{10.1002/cbdv.202301417}},
  year         = {{2023}},
}