The evolution of the ribonucleotide reductases: Much ado about oxygen
Poole, AM ; Logan, Derek LU
and Sjoberg, BM
(2002)
In Journal of Molecular Evolution
55(2).
p.180-196
- Abstract
- Ribonucleotide reduction is the only known biological means for de novo production of deoxyribonucleotides, the building blocks of DNA. These are produced from ribonucleotides, the building blocks of RNA, and the direction of this reaction has been taken to support the idea that, in evolution, RNA preceded DNA as genetic material. However, an understanding of the evolutionary relationships among the three modern-day classes of ribonucleotide reductase and how the first reductase arose early in evolution is still far off. We propose that the diversification of this class of enzymes is inherently tied to microbial colonization of aerobic and anaerobic niches. The work is of broader interest, as it also sheds light on the process of... (More)
- Ribonucleotide reduction is the only known biological means for de novo production of deoxyribonucleotides, the building blocks of DNA. These are produced from ribonucleotides, the building blocks of RNA, and the direction of this reaction has been taken to support the idea that, in evolution, RNA preceded DNA as genetic material. However, an understanding of the evolutionary relationships among the three modern-day classes of ribonucleotide reductase and how the first reductase arose early in evolution is still far off. We propose that the diversification of this class of enzymes is inherently tied to microbial colonization of aerobic and anaerobic niches. The work is of broader interest, as it also sheds light on the process of adaptation to oxygenic environments consequent to the evolution of atmospheric oxygen. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/334116
- author
- Poole, AM
; Logan, Derek
LU
and Sjoberg, BM
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- evolution, oxygen, anaerobic, aerobic, ribonucleotide reductase, DNA origins
- in
- Journal of Molecular Evolution
- volume
- 55
- issue
- 2
- pages
- 180 - 196
- publisher
- Springer
- external identifiers
-
- wos:000176691400005
- pmid:12107594
- scopus:0036306498
- pmid:12107594
- ISSN
- 0022-2844
- DOI
- 10.1007/s00239-002-2315-3
- language
- English
- LU publication?
- yes
- id
- 584f2ba8-9eb3-49ad-9f19-faf1156daacb (old id 334116)
- date added to LUP
- 2016-04-01 11:57:36
- date last changed
- 2022-01-26 20:44:01
@article{584f2ba8-9eb3-49ad-9f19-faf1156daacb,
abstract = {{Ribonucleotide reduction is the only known biological means for de novo production of deoxyribonucleotides, the building blocks of DNA. These are produced from ribonucleotides, the building blocks of RNA, and the direction of this reaction has been taken to support the idea that, in evolution, RNA preceded DNA as genetic material. However, an understanding of the evolutionary relationships among the three modern-day classes of ribonucleotide reductase and how the first reductase arose early in evolution is still far off. We propose that the diversification of this class of enzymes is inherently tied to microbial colonization of aerobic and anaerobic niches. The work is of broader interest, as it also sheds light on the process of adaptation to oxygenic environments consequent to the evolution of atmospheric oxygen.}},
author = {{Poole, AM and Logan, Derek and Sjoberg, BM}},
issn = {{0022-2844}},
keywords = {{evolution; oxygen; anaerobic; aerobic; ribonucleotide reductase; DNA origins}},
language = {{eng}},
number = {{2}},
pages = {{180--196}},
publisher = {{Springer}},
series = {{Journal of Molecular Evolution}},
title = {{The evolution of the ribonucleotide reductases: Much ado about oxygen}},
url = {{http://dx.doi.org/10.1007/s00239-002-2315-3}},
doi = {{10.1007/s00239-002-2315-3}},
volume = {{55}},
year = {{2002}},
}