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Revitalizing donor organs : The potential of mitochondrial transplantation in heart and lung transplantation

Celik, Aybuke LU ; Lindstedt, Sandra LU ; McGiffin, David C. ; Suen, Jacky Y. ; Fraser, John F. ; del Nido, Pedro J. ; Emani, Sitaram M. and McCully, James D. (2025) In Journal of Heart and Lung Transplantation 44(10). p.1648-1658
Abstract

Heart and lung transplantation remain the primary treatments for end-stage organ failure; yet organ shortages and ischemia-reperfusion injury (IRI) limit their success. Extended criteria donors (ECDs) have expanded the donor pool; however, prolonged cold ischemia times increase the risk of primary graft dysfunction (PGD). Static cold storage (SCS), the standard organ preservation method, is suboptimal, leading to mitochondrial dysfunction, ATP depletion, and oxidative stress. Recent advancements in organ storage show promise in maintaining graft viability. Mitochondria are key regulators of cellular homeostasis, and their dysfunction exacerbates IRI, contributing to inflammation and graft failure. Mitochondrial transplantation (MTx) has... (More)

Heart and lung transplantation remain the primary treatments for end-stage organ failure; yet organ shortages and ischemia-reperfusion injury (IRI) limit their success. Extended criteria donors (ECDs) have expanded the donor pool; however, prolonged cold ischemia times increase the risk of primary graft dysfunction (PGD). Static cold storage (SCS), the standard organ preservation method, is suboptimal, leading to mitochondrial dysfunction, ATP depletion, and oxidative stress. Recent advancements in organ storage show promise in maintaining graft viability. Mitochondria are key regulators of cellular homeostasis, and their dysfunction exacerbates IRI, contributing to inflammation and graft failure. Mitochondrial transplantation (MTx) has emerged as a novel therapeutic strategy to restore cellular bioenergetics, reduce oxidative stress, and improve graft function. Further research is needed to optimize MTx protocols and integrate them into current preservation techniques to enhance transplant success and long-term graft survival.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Heart transplantation, Ischemia reperfusion injury, Lung transplantation, Mitochondria, Mitochondrial transplantation, Primary graft dysfunction
in
Journal of Heart and Lung Transplantation
volume
44
issue
10
pages
11 pages
publisher
Elsevier
external identifiers
  • pmid:40623615
  • scopus:105011605333
ISSN
1053-2498
DOI
10.1016/j.healun.2025.07.002
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2025 International Society for the Heart and Lung Transplantation
id
58545bfc-ced9-40e1-be91-e0c83e02e305
date added to LUP
2025-12-19 13:33:05
date last changed
2026-01-02 15:06:23
@article{58545bfc-ced9-40e1-be91-e0c83e02e305,
  abstract     = {{<p>Heart and lung transplantation remain the primary treatments for end-stage organ failure; yet organ shortages and ischemia-reperfusion injury (IRI) limit their success. Extended criteria donors (ECDs) have expanded the donor pool; however, prolonged cold ischemia times increase the risk of primary graft dysfunction (PGD). Static cold storage (SCS), the standard organ preservation method, is suboptimal, leading to mitochondrial dysfunction, ATP depletion, and oxidative stress. Recent advancements in organ storage show promise in maintaining graft viability. Mitochondria are key regulators of cellular homeostasis, and their dysfunction exacerbates IRI, contributing to inflammation and graft failure. Mitochondrial transplantation (MTx) has emerged as a novel therapeutic strategy to restore cellular bioenergetics, reduce oxidative stress, and improve graft function. Further research is needed to optimize MTx protocols and integrate them into current preservation techniques to enhance transplant success and long-term graft survival.</p>}},
  author       = {{Celik, Aybuke and Lindstedt, Sandra and McGiffin, David C. and Suen, Jacky Y. and Fraser, John F. and del Nido, Pedro J. and Emani, Sitaram M. and McCully, James D.}},
  issn         = {{1053-2498}},
  keywords     = {{Heart transplantation; Ischemia reperfusion injury; Lung transplantation; Mitochondria; Mitochondrial transplantation; Primary graft dysfunction}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{1648--1658}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Heart and Lung Transplantation}},
  title        = {{Revitalizing donor organs : The potential of mitochondrial transplantation in heart and lung transplantation}},
  url          = {{http://dx.doi.org/10.1016/j.healun.2025.07.002}},
  doi          = {{10.1016/j.healun.2025.07.002}},
  volume       = {{44}},
  year         = {{2025}},
}