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FDG-accumulating atherosclerotic plaques identified with 18F-FDG-PET/CT in 141 patients

Wassélius, Johan A LU ; Larsson, Stig A LU and Jacobsson, Hans (2009) In Molecular Imaging and Biology 11(6). p.9-455
Abstract

PURPOSE: The aim of this study was to describe the prevalence of atherosclerotic plaques based on [(18)F]-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) in a large population characterized by high risk of cardiovascular disease.

PROCEDURES: One hundred forty-one patients referred to our department for FDG-PET/CT for suspected lung cancer were re-evaluated for atherosclerotic lesions. Cardiovascular risk factors were analyzed based on patient records.

RESULTS: Forty-two percent of the patients had three cardiovascular risk factors or more. Nine percent of all plaques were assessed as active FDG-accumulating plaques, 88% were inactive calcified plaques, and 2% were mixed. The abdominal... (More)

PURPOSE: The aim of this study was to describe the prevalence of atherosclerotic plaques based on [(18)F]-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) in a large population characterized by high risk of cardiovascular disease.

PROCEDURES: One hundred forty-one patients referred to our department for FDG-PET/CT for suspected lung cancer were re-evaluated for atherosclerotic lesions. Cardiovascular risk factors were analyzed based on patient records.

RESULTS: Forty-two percent of the patients had three cardiovascular risk factors or more. Nine percent of all plaques were assessed as active FDG-accumulating plaques, 88% were inactive calcified plaques, and 2% were mixed. The abdominal aorta was the vessel with the highest plaque count. Patients with one risk factor had significantly less active and inactive plaques.

CONCLUSIONS: The observed association between the numbers of cardiovascular risk factors and the numbers of FDG-accumulating plaques as well as calcified plaques further supports the validity and value of FDG-PET/CT in the non-invasive identification and characterization of atherosclerotic disease.

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published
subject
keywords
Aged, Atherosclerosis, Calcinosis, Female, Fluorodeoxyglucose F18, Humans, Male, Positron-Emission Tomography, Radiopharmaceuticals, Risk Factors, Tomography, X-Ray Computed, Journal Article, Research Support, Non-U.S. Gov't
in
Molecular Imaging and Biology
volume
11
issue
6
pages
5 pages
publisher
Springer
external identifiers
  • scopus:70350261795
ISSN
1536-1632
DOI
10.1007/s11307-009-0223-2
language
English
LU publication?
no
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586f4806-072a-46c1-b5bc-ca2e9a9981cc
date added to LUP
2016-10-14 09:56:30
date last changed
2017-01-01 08:36:44
@article{586f4806-072a-46c1-b5bc-ca2e9a9981cc,
  abstract     = {<p>PURPOSE: The aim of this study was to describe the prevalence of atherosclerotic plaques based on [(18)F]-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) in a large population characterized by high risk of cardiovascular disease.</p><p>PROCEDURES: One hundred forty-one patients referred to our department for FDG-PET/CT for suspected lung cancer were re-evaluated for atherosclerotic lesions. Cardiovascular risk factors were analyzed based on patient records.</p><p>RESULTS: Forty-two percent of the patients had three cardiovascular risk factors or more. Nine percent of all plaques were assessed as active FDG-accumulating plaques, 88% were inactive calcified plaques, and 2% were mixed. The abdominal aorta was the vessel with the highest plaque count. Patients with one risk factor had significantly less active and inactive plaques.</p><p>CONCLUSIONS: The observed association between the numbers of cardiovascular risk factors and the numbers of FDG-accumulating plaques as well as calcified plaques further supports the validity and value of FDG-PET/CT in the non-invasive identification and characterization of atherosclerotic disease.</p>},
  author       = {Wassélius, Johan A and Larsson, Stig A and Jacobsson, Hans},
  issn         = {1536-1632},
  keyword      = {Aged,Atherosclerosis,Calcinosis,Female,Fluorodeoxyglucose F18,Humans,Male,Positron-Emission Tomography,Radiopharmaceuticals,Risk Factors,Tomography, X-Ray Computed,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  month        = {05},
  number       = {6},
  pages        = {9--455},
  publisher    = {Springer},
  series       = {Molecular Imaging and Biology},
  title        = {FDG-accumulating atherosclerotic plaques identified with 18F-FDG-PET/CT in 141 patients},
  url          = {http://dx.doi.org/10.1007/s11307-009-0223-2},
  volume       = {11},
  year         = {2009},
}