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FDG-accumulating atherosclerotic plaques identified with 18F-FDG-PET/CT in 141 patients

Wassélius, Johan A LU ; Larsson, Stig A LU and Jacobsson, Hans (2009) In Molecular Imaging and Biology 11(6). p.9-455
Abstract

PURPOSE: The aim of this study was to describe the prevalence of atherosclerotic plaques based on [(18)F]-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) in a large population characterized by high risk of cardiovascular disease.

PROCEDURES: One hundred forty-one patients referred to our department for FDG-PET/CT for suspected lung cancer were re-evaluated for atherosclerotic lesions. Cardiovascular risk factors were analyzed based on patient records.

RESULTS: Forty-two percent of the patients had three cardiovascular risk factors or more. Nine percent of all plaques were assessed as active FDG-accumulating plaques, 88% were inactive calcified plaques, and 2% were mixed. The abdominal... (More)

PURPOSE: The aim of this study was to describe the prevalence of atherosclerotic plaques based on [(18)F]-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) in a large population characterized by high risk of cardiovascular disease.

PROCEDURES: One hundred forty-one patients referred to our department for FDG-PET/CT for suspected lung cancer were re-evaluated for atherosclerotic lesions. Cardiovascular risk factors were analyzed based on patient records.

RESULTS: Forty-two percent of the patients had three cardiovascular risk factors or more. Nine percent of all plaques were assessed as active FDG-accumulating plaques, 88% were inactive calcified plaques, and 2% were mixed. The abdominal aorta was the vessel with the highest plaque count. Patients with one risk factor had significantly less active and inactive plaques.

CONCLUSIONS: The observed association between the numbers of cardiovascular risk factors and the numbers of FDG-accumulating plaques as well as calcified plaques further supports the validity and value of FDG-PET/CT in the non-invasive identification and characterization of atherosclerotic disease.

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author
; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aged, Atherosclerosis, Calcinosis, Female, Fluorodeoxyglucose F18, Humans, Male, Positron-Emission Tomography, Radiopharmaceuticals, Risk Factors, Tomography, X-Ray Computed, Journal Article, Research Support, Non-U.S. Gov't
in
Molecular Imaging and Biology
volume
11
issue
6
pages
5 pages
publisher
Springer Science and Business Media B.V.
external identifiers
  • scopus:70350261795
  • pmid:19424759
ISSN
1536-1632
DOI
10.1007/s11307-009-0223-2
language
English
LU publication?
no
id
586f4806-072a-46c1-b5bc-ca2e9a9981cc
date added to LUP
2016-10-14 09:56:30
date last changed
2025-10-14 11:31:32
@article{586f4806-072a-46c1-b5bc-ca2e9a9981cc,
  abstract     = {{<p>PURPOSE: The aim of this study was to describe the prevalence of atherosclerotic plaques based on [(18)F]-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) in a large population characterized by high risk of cardiovascular disease.</p><p>PROCEDURES: One hundred forty-one patients referred to our department for FDG-PET/CT for suspected lung cancer were re-evaluated for atherosclerotic lesions. Cardiovascular risk factors were analyzed based on patient records.</p><p>RESULTS: Forty-two percent of the patients had three cardiovascular risk factors or more. Nine percent of all plaques were assessed as active FDG-accumulating plaques, 88% were inactive calcified plaques, and 2% were mixed. The abdominal aorta was the vessel with the highest plaque count. Patients with one risk factor had significantly less active and inactive plaques.</p><p>CONCLUSIONS: The observed association between the numbers of cardiovascular risk factors and the numbers of FDG-accumulating plaques as well as calcified plaques further supports the validity and value of FDG-PET/CT in the non-invasive identification and characterization of atherosclerotic disease.</p>}},
  author       = {{Wassélius, Johan A and Larsson, Stig A and Jacobsson, Hans}},
  issn         = {{1536-1632}},
  keywords     = {{Aged; Atherosclerosis; Calcinosis; Female; Fluorodeoxyglucose F18; Humans; Male; Positron-Emission Tomography; Radiopharmaceuticals; Risk Factors; Tomography, X-Ray Computed; Journal Article; Research Support, Non-U.S. Gov't}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{6}},
  pages        = {{9--455}},
  publisher    = {{Springer Science and Business Media B.V.}},
  series       = {{Molecular Imaging and Biology}},
  title        = {{FDG-accumulating atherosclerotic plaques identified with 18F-FDG-PET/CT in 141 patients}},
  url          = {{http://dx.doi.org/10.1007/s11307-009-0223-2}},
  doi          = {{10.1007/s11307-009-0223-2}},
  volume       = {{11}},
  year         = {{2009}},
}