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Patient-reported and performance-based measures of walking in mild–moderate Parkinson's disease

Leavy, Breiffni; Löfgren, Niklas; Nilsson, Maria LU and Franzén, Erika (2018) In Brain and Behavior 8(9).
Abstract

Background: Knowledge of the relationships between patient-reported and performance-based walking measures in Parkinson's disease (PD) should inform clinical decision-making. The Walk-12G reliably captures perceived walking difficulties but has not been compared to performance-based walking in laboratory or free-living settings or across different groups. Objectives: To investigate the relationship between patient-reported walking difficulties (Walk-12G) and performance-based walking in laboratory and free-living conditions and to determine whether the Walk-12G can distinguish between the subgroups, (i) people with/without PD and (ii) mild/moderate disease stages. Methods: Forty-seven people without and 49 people with PD (Hoehn and Yahr... (More)

Background: Knowledge of the relationships between patient-reported and performance-based walking measures in Parkinson's disease (PD) should inform clinical decision-making. The Walk-12G reliably captures perceived walking difficulties but has not been compared to performance-based walking in laboratory or free-living settings or across different groups. Objectives: To investigate the relationship between patient-reported walking difficulties (Walk-12G) and performance-based walking in laboratory and free-living conditions and to determine whether the Walk-12G can distinguish between the subgroups, (i) people with/without PD and (ii) mild/moderate disease stages. Methods: Forty-seven people without and 49 people with PD (Hoehn and Yahr stage II and III) were assessed in relation to patient-reported walking difficulties (Walk-12G scale); spatiotemporal gait characteristics (Pace; Rhythm; Asymmetry; Variability; and Postural control) using a laboratory-based electronic walkway; and walking behavior (mean steps/day and minutes of brisk walking/day) using accelerometers in free-living conditions. Results: The Walk-12G correlated moderately with the spatiotemporal domain step velocity (r = −0.46) and walking behavior, measured as mean steps/day (r = −0.46). Weaker correlations were observed for step length and minutes spent in brisk walking (r = −0.36 and r = −0.35, respectively). Poor correlations were observed for all other spatiotemporal domains. The Walk-12G could distinguish between people with and without PD (Effect size, r = 0.82) and between those at mild/moderate disease stages (r = 0.34). Conclusions: Perceived walking difficulties showed weak to moderate associations with performance-based measures of walking in mild–moderate PD. As the strongest associations were observed for step velocity and walking behavior, targeting these specific gait aspects could improve perceived walking difficulties in daily life.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
outcome assessment, Parkinson's disease, walking
in
Brain and Behavior
volume
8
issue
9
publisher
John Wiley & Sons
external identifiers
  • scopus:85052656419
ISSN
2157-9032
DOI
10.1002/brb3.1081
language
English
LU publication?
yes
id
58acbce8-909c-4c91-a0bf-e48e10495d52
date added to LUP
2018-09-28 11:10:53
date last changed
2019-01-14 18:07:57
@article{58acbce8-909c-4c91-a0bf-e48e10495d52,
  abstract     = {<p>Background: Knowledge of the relationships between patient-reported and performance-based walking measures in Parkinson's disease (PD) should inform clinical decision-making. The Walk-12G reliably captures perceived walking difficulties but has not been compared to performance-based walking in laboratory or free-living settings or across different groups. Objectives: To investigate the relationship between patient-reported walking difficulties (Walk-12G) and performance-based walking in laboratory and free-living conditions and to determine whether the Walk-12G can distinguish between the subgroups, (i) people with/without PD and (ii) mild/moderate disease stages. Methods: Forty-seven people without and 49 people with PD (Hoehn and Yahr stage II and III) were assessed in relation to patient-reported walking difficulties (Walk-12G scale); spatiotemporal gait characteristics (Pace; Rhythm; Asymmetry; Variability; and Postural control) using a laboratory-based electronic walkway; and walking behavior (mean steps/day and minutes of brisk walking/day) using accelerometers in free-living conditions. Results: The Walk-12G correlated moderately with the spatiotemporal domain step velocity (r = −0.46) and walking behavior, measured as mean steps/day (r = −0.46). Weaker correlations were observed for step length and minutes spent in brisk walking (r = −0.36 and r = −0.35, respectively). Poor correlations were observed for all other spatiotemporal domains. The Walk-12G could distinguish between people with and without PD (Effect size, r = 0.82) and between those at mild/moderate disease stages (r = 0.34). Conclusions: Perceived walking difficulties showed weak to moderate associations with performance-based measures of walking in mild–moderate PD. As the strongest associations were observed for step velocity and walking behavior, targeting these specific gait aspects could improve perceived walking difficulties in daily life.</p>},
  articleno    = {e01081},
  author       = {Leavy, Breiffni and Löfgren, Niklas and Nilsson, Maria and Franzén, Erika},
  issn         = {2157-9032},
  keyword      = {outcome assessment,Parkinson's disease,walking},
  language     = {eng},
  month        = {08},
  number       = {9},
  publisher    = {John Wiley & Sons},
  series       = {Brain and Behavior},
  title        = {Patient-reported and performance-based measures of walking in mild–moderate Parkinson's disease},
  url          = {http://dx.doi.org/10.1002/brb3.1081},
  volume       = {8},
  year         = {2018},
}