Plasma neurofilament light associates with Alzheimer's disease metabolic decline in amyloid-positive individuals
(2019) In Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring 11. p.679-689- Abstract
Introduction: Neurofilament light chain (NfL) is a promising blood biomarker to detect neurodegeneration in Alzheimer's disease (AD) and other brain disorders. However, there are limited reports of how longitudinal NfL relates to imaging biomarkers. We herein investigated the relationship between blood NfL and brain metabolism in AD. Methods: Voxelwise regression models tested the cross-sectional association between [18F]fluorodeoxyglucose ([18F]FDG) and both plasma and cerebrospinal fluid NfL in cognitively impaired and unimpaired subjects. Linear mixed models were also used to test the longitudinal association between NfL and [18F]FDG in amyloid positive (Aβ+) and negative (Aβ−) subjects. Results:... (More)
Introduction: Neurofilament light chain (NfL) is a promising blood biomarker to detect neurodegeneration in Alzheimer's disease (AD) and other brain disorders. However, there are limited reports of how longitudinal NfL relates to imaging biomarkers. We herein investigated the relationship between blood NfL and brain metabolism in AD. Methods: Voxelwise regression models tested the cross-sectional association between [18F]fluorodeoxyglucose ([18F]FDG) and both plasma and cerebrospinal fluid NfL in cognitively impaired and unimpaired subjects. Linear mixed models were also used to test the longitudinal association between NfL and [18F]FDG in amyloid positive (Aβ+) and negative (Aβ−) subjects. Results: Higher concentrations of plasma and cerebrospinal fluid NfL were associated with reduced [18F]FDG uptake in correspondent brain regions. In Aβ+ participants, NfL associates with hypometabolism in AD-vulnerable regions. Longitudinal changes in the association [18F]FDG-NfL were confined to cognitively impaired Aβ+ individuals. Discussion: These findings indicate that plasma NfL is a proxy for neurodegeneration in AD-related regions in Aβ+ subjects.
(Less)
- author
- author collaboration
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Alzheimer's disease, Biomarkers, Blood, Hypometabolism, Longitudinal, Neurodegeneration, Neurofilament light, PET, [F]FDG
- in
- Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
- volume
- 11
- pages
- 11 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85072700126
- pmid:31673598
- ISSN
- 2352-8729
- DOI
- 10.1016/j.dadm.2019.08.002
- language
- English
- LU publication?
- yes
- id
- 58af0059-756c-48eb-9ae0-ab1a50d06467
- date added to LUP
- 2019-10-09 14:18:22
- date last changed
- 2024-07-25 07:00:11
@article{58af0059-756c-48eb-9ae0-ab1a50d06467, abstract = {{<p>Introduction: Neurofilament light chain (NfL) is a promising blood biomarker to detect neurodegeneration in Alzheimer's disease (AD) and other brain disorders. However, there are limited reports of how longitudinal NfL relates to imaging biomarkers. We herein investigated the relationship between blood NfL and brain metabolism in AD. Methods: Voxelwise regression models tested the cross-sectional association between [<sup>18</sup>F]fluorodeoxyglucose ([<sup>18</sup>F]FDG) and both plasma and cerebrospinal fluid NfL in cognitively impaired and unimpaired subjects. Linear mixed models were also used to test the longitudinal association between NfL and [<sup>18</sup>F]FDG in amyloid positive (Aβ+) and negative (Aβ−) subjects. Results: Higher concentrations of plasma and cerebrospinal fluid NfL were associated with reduced [<sup>18</sup>F]FDG uptake in correspondent brain regions. In Aβ+ participants, NfL associates with hypometabolism in AD-vulnerable regions. Longitudinal changes in the association [<sup>18</sup>F]FDG-NfL were confined to cognitively impaired Aβ+ individuals. Discussion: These findings indicate that plasma NfL is a proxy for neurodegeneration in AD-related regions in Aβ+ subjects.</p>}}, author = {{Benedet, Andréa L. and Ashton, Nicholas J. and Pascoal, Tharick A. and Leuzy, Antoine and Mathotaarachchi, Sulantha and Kang, Min S. and Therriault, Joseph and Savard, Melissa and Chamoun, Mira and Schöll, Michael and Zimmer, Eduardo R. and Gauthier, Serge and Labbe, Aurélie and Zetterberg, Henrik and Blennow, Kaj and Neto, Pedro R.}}, issn = {{2352-8729}}, keywords = {{Alzheimer's disease; Biomarkers; Blood; Hypometabolism; Longitudinal; Neurodegeneration; Neurofilament light; PET; [F]FDG}}, language = {{eng}}, pages = {{679--689}}, publisher = {{Elsevier}}, series = {{Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring}}, title = {{Plasma neurofilament light associates with Alzheimer's disease metabolic decline in amyloid-positive individuals}}, url = {{http://dx.doi.org/10.1016/j.dadm.2019.08.002}}, doi = {{10.1016/j.dadm.2019.08.002}}, volume = {{11}}, year = {{2019}}, }