A scoping review of remote and unsupervised digital cognitive assessments in preclinical Alzheimer’s disease
(2025) In npj Digital Medicine 8(1).- Abstract
Characterizing subtle cognitive changes in preclinical Alzheimer’s disease (AD) is difficult using traditional neuropsychological assessments. Remote and unsupervised digital assessments can improve scalability, measurement reliability, and ecological validity, enabling the capture of subtle changes. We evaluate such tools for use in preclinical AD, or cognitively unimpaired individuals with abnormal levels of AD pathology. We screened 1904 reports for studies remotely assessing cognition in preclinical AD samples. Twenty-three tools were identified, and their usability, reliability, and validity, including construct and criterion validity based on in-person neuropsychological and Aβ/tau measures, was reported. We present a necessary... (More)
Characterizing subtle cognitive changes in preclinical Alzheimer’s disease (AD) is difficult using traditional neuropsychological assessments. Remote and unsupervised digital assessments can improve scalability, measurement reliability, and ecological validity, enabling the capture of subtle changes. We evaluate such tools for use in preclinical AD, or cognitively unimpaired individuals with abnormal levels of AD pathology. We screened 1904 reports for studies remotely assessing cognition in preclinical AD samples. Twenty-three tools were identified, and their usability, reliability, and validity, including construct and criterion validity based on in-person neuropsychological and Aβ/tau measures, was reported. We present a necessary update to a rapidly evolving field, following our previous review (Öhman et al., 2021) and address open questions of feasibility and reliability of remote testing in older adults. Future applications of such tools are discussed, including longitudinal monitoring of cognition, scalable case finding, and individualized prognostics in both clinical trials and healthcare contexts.
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- author
- Polk, Sarah E. ; Öhman, Fredrik ; Hassenstab, Jason ; König, Alexandra ; Papp, Kathryn V. ; Schöll, Michael LU and Berron, David LU
- organization
- publishing date
- 2025-12
- type
- Contribution to journal
- publication status
- published
- subject
- in
- npj Digital Medicine
- volume
- 8
- issue
- 1
- article number
- 266
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:105004642127
- pmid:40348870
- ISSN
- 2398-6352
- DOI
- 10.1038/s41746-025-01583-5
- language
- English
- LU publication?
- yes
- id
- 58d26b88-29a8-4d30-86f2-2cfd073e4f7d
- date added to LUP
- 2025-07-11 10:54:22
- date last changed
- 2025-07-12 03:00:02
@article{58d26b88-29a8-4d30-86f2-2cfd073e4f7d,
abstract = {{<p>Characterizing subtle cognitive changes in preclinical Alzheimer’s disease (AD) is difficult using traditional neuropsychological assessments. Remote and unsupervised digital assessments can improve scalability, measurement reliability, and ecological validity, enabling the capture of subtle changes. We evaluate such tools for use in preclinical AD, or cognitively unimpaired individuals with abnormal levels of AD pathology. We screened 1904 reports for studies remotely assessing cognition in preclinical AD samples. Twenty-three tools were identified, and their usability, reliability, and validity, including construct and criterion validity based on in-person neuropsychological and Aβ/tau measures, was reported. We present a necessary update to a rapidly evolving field, following our previous review (Öhman et al., 2021) and address open questions of feasibility and reliability of remote testing in older adults. Future applications of such tools are discussed, including longitudinal monitoring of cognition, scalable case finding, and individualized prognostics in both clinical trials and healthcare contexts.</p>}},
author = {{Polk, Sarah E. and Öhman, Fredrik and Hassenstab, Jason and König, Alexandra and Papp, Kathryn V. and Schöll, Michael and Berron, David}},
issn = {{2398-6352}},
language = {{eng}},
number = {{1}},
publisher = {{Nature Publishing Group}},
series = {{npj Digital Medicine}},
title = {{A scoping review of remote and unsupervised digital cognitive assessments in preclinical Alzheimer’s disease}},
url = {{http://dx.doi.org/10.1038/s41746-025-01583-5}},
doi = {{10.1038/s41746-025-01583-5}},
volume = {{8}},
year = {{2025}},
}