Current and Emerging Pharmacological Targets and Treatments of Urinary Incontinence and Related Disorders
Michel, Martin C. ; Cardozo, Linda ; Chermansky, Christopher J. ; Cruz, Francisco ; Igawa, Yasuhiko ; Lee, Kyu Sung ; Sahai, Arun ; Wein, Alan J. and Andersson, Karl Erik LU
(2023)
In Pharmacological Reviews
75(4).
p.554-674
- Abstract
Overactive bladder syndrome with and without urinary incontinence and related conditions, signs, and disorders such as detrusor overactivity, neurogenic lower urinary tract dysfunction, underactive bladder, stress urinary incontinence, and nocturia are common in the general population and have amajor impact on the quality of life of the affected patients and their partners. Based on the deliberations of the subcommittee on pharmacological treatments of the 7th International Consultation on Incontinence, we present a comprehensive review of established drug targets in the treatment of overactive bladder syndrome and the aforementioned related conditions and the approved drugs used in its treatment. Investigational drug targets and... (More)
Overactive bladder syndrome with and without urinary incontinence and related conditions, signs, and disorders such as detrusor overactivity, neurogenic lower urinary tract dysfunction, underactive bladder, stress urinary incontinence, and nocturia are common in the general population and have amajor impact on the quality of life of the affected patients and their partners. Based on the deliberations of the subcommittee on pharmacological treatments of the 7th International Consultation on Incontinence, we present a comprehensive review of established drug targets in the treatment of overactive bladder syndrome and the aforementioned related conditions and the approved drugs used in its treatment. Investigational drug targets and compounds are also reviewed.We conclude that, despite a range of available medical treatment options, a considerable medical need continues to exist. This is largely because the existing treatments are symptomatic and have limited efficacy and/or tolerability, which leads to poor long-termadherence. Significance Statement——Urinary incontinence and related disorders are prevalent in the general population. Whilemany treatments have been approved, few patients stay on long-term treatment despite none of them being curative. This paper provides a comprehensive discussion of existing and emerging treatment options for various types of incontinence and related disorders.
(Less)
- author
- Michel, Martin C.
; Cardozo, Linda
; Chermansky, Christopher J.
; Cruz, Francisco
; Igawa, Yasuhiko
; Lee, Kyu Sung
; Sahai, Arun
; Wein, Alan J.
and Andersson, Karl Erik
LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Pharmacological Reviews
- volume
- 75
- issue
- 4
- pages
- 121 pages
- publisher
- American Society for Pharmacology and Experimental Therapeutics
- external identifiers
-
- pmid:36918261
- scopus:85163750664
- ISSN
- 0031-6997
- DOI
- 10.1124/pharmrev.121.000523
- language
- English
- LU publication?
- yes
- id
- 58fac520-31d3-4775-8440-1a4274a1b078
- date added to LUP
- 2023-09-14 14:14:12
- date last changed
- 2024-04-20 03:15:15
@article{58fac520-31d3-4775-8440-1a4274a1b078,
abstract = {{<p>Overactive bladder syndrome with and without urinary incontinence and related conditions, signs, and disorders such as detrusor overactivity, neurogenic lower urinary tract dysfunction, underactive bladder, stress urinary incontinence, and nocturia are common in the general population and have amajor impact on the quality of life of the affected patients and their partners. Based on the deliberations of the subcommittee on pharmacological treatments of the 7th International Consultation on Incontinence, we present a comprehensive review of established drug targets in the treatment of overactive bladder syndrome and the aforementioned related conditions and the approved drugs used in its treatment. Investigational drug targets and compounds are also reviewed.We conclude that, despite a range of available medical treatment options, a considerable medical need continues to exist. This is largely because the existing treatments are symptomatic and have limited efficacy and/or tolerability, which leads to poor long-termadherence. Significance Statement——Urinary incontinence and related disorders are prevalent in the general population. Whilemany treatments have been approved, few patients stay on long-term treatment despite none of them being curative. This paper provides a comprehensive discussion of existing and emerging treatment options for various types of incontinence and related disorders.</p>}},
author = {{Michel, Martin C. and Cardozo, Linda and Chermansky, Christopher J. and Cruz, Francisco and Igawa, Yasuhiko and Lee, Kyu Sung and Sahai, Arun and Wein, Alan J. and Andersson, Karl Erik}},
issn = {{0031-6997}},
language = {{eng}},
number = {{4}},
pages = {{554--674}},
publisher = {{American Society for Pharmacology and Experimental Therapeutics}},
series = {{Pharmacological Reviews}},
title = {{Current and Emerging Pharmacological Targets and Treatments of Urinary Incontinence and Related Disorders}},
url = {{http://dx.doi.org/10.1124/pharmrev.121.000523}},
doi = {{10.1124/pharmrev.121.000523}},
volume = {{75}},
year = {{2023}},
}