Humoral immunity targeting site I of antigenic domain 2 of glycoprotein B upon immunization with different cytomegalovirus candidate vaccines.
(2007) In Vaccine 26(1). p.41-46- Abstract
- Glycoprotein B (gB) is a major component in several vaccines that are under development for prevention of disease by cytomegalovirus. It contains multiple determinants that are targets for neutralizing antibodies. One of them is site I of antigenic domain 2 (AD-2). The epitope, defined by short peptides, is quite conserved between different isolates. However, it is poorly immunogenic in natural infection. In this study we investigated the extent to which different vaccines, attenuated live Towne vaccine with or without priming with a canarypox virus coding for gB, or a recombinant gB vaccine adjuvanted with MF59, induced antibodies to this epitope. As in natural infection only a fraction of all subjects developed antibody responses against... (More)
- Glycoprotein B (gB) is a major component in several vaccines that are under development for prevention of disease by cytomegalovirus. It contains multiple determinants that are targets for neutralizing antibodies. One of them is site I of antigenic domain 2 (AD-2). The epitope, defined by short peptides, is quite conserved between different isolates. However, it is poorly immunogenic in natural infection. In this study we investigated the extent to which different vaccines, attenuated live Towne vaccine with or without priming with a canarypox virus coding for gB, or a recombinant gB vaccine adjuvanted with MF59, induced antibodies to this epitope. As in natural infection only a fraction of all subjects developed antibody responses against site I of AD-2 following vaccination. We suggest that strategies that enhance immunogenicity of this epitope will improve vaccine efficacy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/594348
- author
- Carlsson, Fredrika
LU
; Adler, SP
; Lamarre, A
and Ohlin, Mats
LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Viral/blood, Cytomegalovirus Vaccines/immunology, Epitope Mapping, Humans, Immunization, Protein Structure, Antibodies, Tertiary, Vaccines, Attenuated/immunology, Synthetic/immunology, Viral Envelope Proteins/chemistry, Viral Envelope Proteins/immunology
- in
- Vaccine
- volume
- 26
- issue
- 1
- pages
- 41 - 46
- publisher
- Elsevier
- external identifiers
-
- pmid:18063447
- wos:000252490700005
- scopus:36749092916
- pmid:18063447
- ISSN
- 1873-2518
- DOI
- 10.1016/j.vaccine.2007.10.048
- language
- English
- LU publication?
- yes
- id
- 4c8d89e6-74bb-4906-be28-9b2b915f45af (old id 594348)
- date added to LUP
- 2016-04-01 12:17:38
- date last changed
- 2022-03-21 02:12:02
@article{4c8d89e6-74bb-4906-be28-9b2b915f45af, abstract = {{Glycoprotein B (gB) is a major component in several vaccines that are under development for prevention of disease by cytomegalovirus. It contains multiple determinants that are targets for neutralizing antibodies. One of them is site I of antigenic domain 2 (AD-2). The epitope, defined by short peptides, is quite conserved between different isolates. However, it is poorly immunogenic in natural infection. In this study we investigated the extent to which different vaccines, attenuated live Towne vaccine with or without priming with a canarypox virus coding for gB, or a recombinant gB vaccine adjuvanted with MF59, induced antibodies to this epitope. As in natural infection only a fraction of all subjects developed antibody responses against site I of AD-2 following vaccination. We suggest that strategies that enhance immunogenicity of this epitope will improve vaccine efficacy.}}, author = {{Carlsson, Fredrika and Adler, SP and Lamarre, A and Ohlin, Mats}}, issn = {{1873-2518}}, keywords = {{Viral/blood; Cytomegalovirus Vaccines/immunology; Epitope Mapping; Humans; Immunization; Protein Structure; Antibodies; Tertiary; Vaccines; Attenuated/immunology; Synthetic/immunology; Viral Envelope Proteins/chemistry; Viral Envelope Proteins/immunology}}, language = {{eng}}, number = {{1}}, pages = {{41--46}}, publisher = {{Elsevier}}, series = {{Vaccine}}, title = {{Humoral immunity targeting site I of antigenic domain 2 of glycoprotein B upon immunization with different cytomegalovirus candidate vaccines.}}, url = {{http://dx.doi.org/10.1016/j.vaccine.2007.10.048}}, doi = {{10.1016/j.vaccine.2007.10.048}}, volume = {{26}}, year = {{2007}}, }