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Membranous expression of podocalyxin-like protein is an independent factor of poor prognosis in urothelial bladder cancer.

Boman, Karolina LU ; Larsson, Anna H LU ; Segersten, U ; Kuteeva, E ; Johannesson, Henrik ; Nodin, Björn LU ; Eberhard, Jakob LU ; Uhlén, M ; Malmström, P-U and Jirström, Karin LU orcid (2013) In British Journal of Cancer 108(11). p.2321-2328
Abstract
Background:Membranous expression of the anti-adhesive glycoprotein podocalyxin-like (PODXL) has previously been found to correlate with poor prognosis in several major cancer forms. Here we examined the prognostic impact of PODXL expression in urothelial bladder cancer.Methods:Immunohistochemical PODXL expression was examined in tissue microarrays with tumours from two independent cohorts of patients with urothelial bladder cancer: n=100 (Cohort I) and n=343 (Cohort II). The impact of PODXL expression on disease-specific survival (DSS; Cohort II), 5-year overall survival (OS; both cohorts) and 2-year progression-free survival (PFS; Cohort II) was assessed.Results:Membranous PODXL expression was significantly associated with more advanced... (More)
Background:Membranous expression of the anti-adhesive glycoprotein podocalyxin-like (PODXL) has previously been found to correlate with poor prognosis in several major cancer forms. Here we examined the prognostic impact of PODXL expression in urothelial bladder cancer.Methods:Immunohistochemical PODXL expression was examined in tissue microarrays with tumours from two independent cohorts of patients with urothelial bladder cancer: n=100 (Cohort I) and n=343 (Cohort II). The impact of PODXL expression on disease-specific survival (DSS; Cohort II), 5-year overall survival (OS; both cohorts) and 2-year progression-free survival (PFS; Cohort II) was assessed.Results:Membranous PODXL expression was significantly associated with more advanced tumour (T) stage and high-grade tumours in both cohorts, and a significantly reduced 5-year OS (unadjusted HR=2.25 in Cohort I and 3.10 in Cohort II, adjusted HR=2.05 in Cohort I and 2.18 in Cohort II) and DSS (unadjusted HR=4.36, adjusted HR=2.70). In patients with Ta and T1 tumours, membranous PODXL expression was an independent predictor of a reduced 2-year PFS (unadjusted HR=6.19, adjusted HR=4.60) and DSS (unadjusted HR=8.34, adjusted HR=7.16).Conclusion:Membranous PODXL expression is an independent risk factor for progressive disease and death in patients with urothelial bladder cancer.British Journal of Cancer advance online publication, 7 May 2013; doi:10.1038/bjc.2013.215 www.bjcancer.com. (Less)
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Cancer
volume
108
issue
11
pages
2321 - 2328
publisher
Nature Publishing Group
external identifiers
  • wos:000320249500016
  • pmid:23652315
  • scopus:84884185522
  • pmid:23652315
ISSN
1532-1827
DOI
10.1038/bjc.2013.215
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Oncology, MV (013035000)
id
59451232-9eb4-425f-8401-661993b0f9fa (old id 3804795)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23652315?dopt=Abstract
date added to LUP
2016-04-01 10:07:38
date last changed
2024-01-06 08:19:59
@article{59451232-9eb4-425f-8401-661993b0f9fa,
  abstract     = {{Background:Membranous expression of the anti-adhesive glycoprotein podocalyxin-like (PODXL) has previously been found to correlate with poor prognosis in several major cancer forms. Here we examined the prognostic impact of PODXL expression in urothelial bladder cancer.Methods:Immunohistochemical PODXL expression was examined in tissue microarrays with tumours from two independent cohorts of patients with urothelial bladder cancer: n=100 (Cohort I) and n=343 (Cohort II). The impact of PODXL expression on disease-specific survival (DSS; Cohort II), 5-year overall survival (OS; both cohorts) and 2-year progression-free survival (PFS; Cohort II) was assessed.Results:Membranous PODXL expression was significantly associated with more advanced tumour (T) stage and high-grade tumours in both cohorts, and a significantly reduced 5-year OS (unadjusted HR=2.25 in Cohort I and 3.10 in Cohort II, adjusted HR=2.05 in Cohort I and 2.18 in Cohort II) and DSS (unadjusted HR=4.36, adjusted HR=2.70). In patients with Ta and T1 tumours, membranous PODXL expression was an independent predictor of a reduced 2-year PFS (unadjusted HR=6.19, adjusted HR=4.60) and DSS (unadjusted HR=8.34, adjusted HR=7.16).Conclusion:Membranous PODXL expression is an independent risk factor for progressive disease and death in patients with urothelial bladder cancer.British Journal of Cancer advance online publication, 7 May 2013; doi:10.1038/bjc.2013.215 www.bjcancer.com.}},
  author       = {{Boman, Karolina and Larsson, Anna H and Segersten, U and Kuteeva, E and Johannesson, Henrik and Nodin, Björn and Eberhard, Jakob and Uhlén, M and Malmström, P-U and Jirström, Karin}},
  issn         = {{1532-1827}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{2321--2328}},
  publisher    = {{Nature Publishing Group}},
  series       = {{British Journal of Cancer}},
  title        = {{Membranous expression of podocalyxin-like protein is an independent factor of poor prognosis in urothelial bladder cancer.}},
  url          = {{http://dx.doi.org/10.1038/bjc.2013.215}},
  doi          = {{10.1038/bjc.2013.215}},
  volume       = {{108}},
  year         = {{2013}},
}