Age-Dependent Alpha-Synuclein Accumulation and Phosphorylation in the Enteric Nervous System in a Transgenic Mouse Model of Parkinson’s Disease
Zhong, Chong Bin ; Chen, Qian Qian ; Haikal, Caroline LU ; Li, Wen LU ; Svanbergsson, Alexander LU
; Diepenbroek, Meike
LU
and Li, Jia Yi
LU
(2017)
In Neuroscience Bulletin
33(5).
p.483-492
- Abstract
The enteric nervous system (ENS) controls the function of the gastrointestinal tract and has been implicated in various diseases, including Parkinson’s disease (PD). PD is a neurodegenerative disease with Lewy bodies (LBs) and Lewy neurites (LNs) as the main pathological features. In addition to the typical motor symptoms in PD, attention has been drawn to non-motor symptoms, such as constipation, implying dysfunction of the ENS. In the present study, we characterized the age-dependent morphological alterations and aggregation of α-synuclein (α-syn), the primary protein component in LBs and LNs, in the ENS in an α-syn transgenic mouse model. We found that the expression and accumulation of α-syn increased gradually in neurons of... (More)
The enteric nervous system (ENS) controls the function of the gastrointestinal tract and has been implicated in various diseases, including Parkinson’s disease (PD). PD is a neurodegenerative disease with Lewy bodies (LBs) and Lewy neurites (LNs) as the main pathological features. In addition to the typical motor symptoms in PD, attention has been drawn to non-motor symptoms, such as constipation, implying dysfunction of the ENS. In the present study, we characterized the age-dependent morphological alterations and aggregation of α-synuclein (α-syn), the primary protein component in LBs and LNs, in the ENS in an α-syn transgenic mouse model. We found that the expression and accumulation of α-syn increased gradually in neurons of Meissner’s and Auerbach’s plexuses of the gastrointestinal tract with age (from 1 week to 2 years). In addition, α-syn was increasingly phosphorylated at the serine 129 residue, reflecting pathological alterations of the protein over time. Furthermore, α-syn was present in different subtypes of neurons expressing vasoactive intestinal polypeptide, neuronal nitric oxide synthase, or calretinin. The results indicated that BAC-α-Syn-GFP transgenic mice provide a unique model in which to study the relationship between ENS and PD pathogenesis.
(Less)
- author
- Zhong, Chong Bin
; Chen, Qian Qian
; Haikal, Caroline
LU
; Li, Wen
LU
; Svanbergsson, Alexander
LU
; Diepenbroek, Meike
LU
and Li, Jia Yi
LU
- organization
- publishing date
- 2017-09-18
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Enteric system, Parkinson’s disease, Phosphorylation, Protein aggregation, α-synuclein
- in
- Neuroscience Bulletin
- volume
- 33
- issue
- 5
- pages
- 483 - 492
- publisher
- Springer
- external identifiers
-
- pmid:28924920
- wos:000412740300002
- scopus:85029582398
- ISSN
- 1673-7067
- DOI
- 10.1007/s12264-017-0179-1
- language
- English
- LU publication?
- yes
- id
- 5953b66f-1aa2-4075-9aa8-fe453812079f
- date added to LUP
- 2017-09-29 10:58:37
- date last changed
- 2024-02-13 07:10:20
@article{5953b66f-1aa2-4075-9aa8-fe453812079f,
abstract = {{<p>The enteric nervous system (ENS) controls the function of the gastrointestinal tract and has been implicated in various diseases, including Parkinson’s disease (PD). PD is a neurodegenerative disease with Lewy bodies (LBs) and Lewy neurites (LNs) as the main pathological features. In addition to the typical motor symptoms in PD, attention has been drawn to non-motor symptoms, such as constipation, implying dysfunction of the ENS. In the present study, we characterized the age-dependent morphological alterations and aggregation of α-synuclein (α-syn), the primary protein component in LBs and LNs, in the ENS in an α-syn transgenic mouse model. We found that the expression and accumulation of α-syn increased gradually in neurons of Meissner’s and Auerbach’s plexuses of the gastrointestinal tract with age (from 1 week to 2 years). In addition, α-syn was increasingly phosphorylated at the serine 129 residue, reflecting pathological alterations of the protein over time. Furthermore, α-syn was present in different subtypes of neurons expressing vasoactive intestinal polypeptide, neuronal nitric oxide synthase, or calretinin. The results indicated that BAC-α-Syn-GFP transgenic mice provide a unique model in which to study the relationship between ENS and PD pathogenesis.</p>}},
author = {{Zhong, Chong Bin and Chen, Qian Qian and Haikal, Caroline and Li, Wen and Svanbergsson, Alexander and Diepenbroek, Meike and Li, Jia Yi}},
issn = {{1673-7067}},
keywords = {{Enteric system; Parkinson’s disease; Phosphorylation; Protein aggregation; α-synuclein}},
language = {{eng}},
month = {{09}},
number = {{5}},
pages = {{483--492}},
publisher = {{Springer}},
series = {{Neuroscience Bulletin}},
title = {{Age-Dependent Alpha-Synuclein Accumulation and Phosphorylation in the Enteric Nervous System in a Transgenic Mouse Model of Parkinson’s Disease}},
url = {{http://dx.doi.org/10.1007/s12264-017-0179-1}},
doi = {{10.1007/s12264-017-0179-1}},
volume = {{33}},
year = {{2017}},
}