Controlling the microclimate of the skin though the application of occluding films
(2012) In Journal of the Royal Society Interface- Abstract
- The skin barrier is a responding membrane that separates environments with profoundly different
water contents. This implies a substantial water gradient across the skin membrane, which controls
transepidermal water loss (TEWL) and skin hydration. We define the microclimate of the skin as
the activity of water in the outermost layer of skin. By applying an occluding film composed of a
pharmaceutical or cosmetic formulation on the skin surface, it is possible to alter the resistance to
water evaporation from the body and to increase the microclimate at the skin surface. This way, the
occluding film can be used to increase the skin hydration.
In this study, we develop a... (More) - The skin barrier is a responding membrane that separates environments with profoundly different
water contents. This implies a substantial water gradient across the skin membrane, which controls
transepidermal water loss (TEWL) and skin hydration. We define the microclimate of the skin as
the activity of water in the outermost layer of skin. By applying an occluding film composed of a
pharmaceutical or cosmetic formulation on the skin surface, it is possible to alter the resistance to
water evaporation from the body and to increase the microclimate at the skin surface. This way, the
occluding film can be used to increase the skin hydration.
In this study, we develop a quantitative method to predict how occluding creams affect skin
hydration. The cosmetic or pharmaceutical product forms a film at the skin surface, which is
described in terms of its specific occlusivity. We present a theoretical model that couples transport
and hydration in responding skin membranes after the application of the film, and an experimental
method to determine the specific occlusivity of films. Finally, we combine the experimental
measures with the theoretical model to obtain a quantitative tool to predict how occluding creams
affect the skin microclimate, the TEWL and the hydration of the upper layer of stratum corneum. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3222664
- author
- Sparr, Emma LU ; Millecamp, Danielle ; Isoir, Muriel ; Burnier, Véronique ; Larsson, Åsa LU and Cabane, Bernard
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- in press
- subject
- keywords
- water transport, specific occlusivity, responding membrane, model emulsions, permeability, hydration
- in
- Journal of the Royal Society Interface
- publisher
- The Royal Society of Canada
- ISSN
- 1742-5662
- language
- English
- LU publication?
- yes
- id
- 5996ee9b-90f1-4ca1-9f98-e9ad95d86411 (old id 3222664)
- date added to LUP
- 2016-04-01 10:49:49
- date last changed
- 2018-11-21 19:51:25
@article{5996ee9b-90f1-4ca1-9f98-e9ad95d86411,
abstract = {{The skin barrier is a responding membrane that separates environments with profoundly different<br/><br>
water contents. This implies a substantial water gradient across the skin membrane, which controls<br/><br>
transepidermal water loss (TEWL) and skin hydration. We define the microclimate of the skin as<br/><br>
the activity of water in the outermost layer of skin. By applying an occluding film composed of a<br/><br>
pharmaceutical or cosmetic formulation on the skin surface, it is possible to alter the resistance to<br/><br>
water evaporation from the body and to increase the microclimate at the skin surface. This way, the<br/><br>
occluding film can be used to increase the skin hydration.<br/><br>
In this study, we develop a quantitative method to predict how occluding creams affect skin<br/><br>
hydration. The cosmetic or pharmaceutical product forms a film at the skin surface, which is<br/><br>
described in terms of its specific occlusivity. We present a theoretical model that couples transport<br/><br>
and hydration in responding skin membranes after the application of the film, and an experimental<br/><br>
method to determine the specific occlusivity of films. Finally, we combine the experimental<br/><br>
measures with the theoretical model to obtain a quantitative tool to predict how occluding creams<br/><br>
affect the skin microclimate, the TEWL and the hydration of the upper layer of stratum corneum.}},
author = {{Sparr, Emma and Millecamp, Danielle and Isoir, Muriel and Burnier, Véronique and Larsson, Åsa and Cabane, Bernard}},
issn = {{1742-5662}},
keywords = {{water transport; specific occlusivity; responding membrane; model emulsions; permeability; hydration}},
language = {{eng}},
publisher = {{The Royal Society of Canada}},
series = {{Journal of the Royal Society Interface}},
title = {{Controlling the microclimate of the skin though the application of occluding films}},
year = {{2012}},
}