Bradur nyrnaskadi a Landspitala 2008-2011 og ahaettupaettir og afdrif sjuklinga med alvarlegan skada
(2013) In Laeknabladid 99(11). p.499-503- Abstract
INTRODUCTION: Acute kidney injury (AKI) is a common problem in hospitalized patients, requiring extensive treatment and carries a high mortality rate. This study was designed to assess the epidemiology of AKI, and risk factors and outcome of patients with severe AKI in a tertiary care university hospital in Iceland.
MATERIAL AND METHODS: All adult patients with measured serum creatinine (SCr) in Landspitali University Hospital from January 2008 to December 2011, who had a measured baseline SCr in the preceeding six months, were included. Patients were categorized according to the RIFLE-criteria into risk (stage 1), injury (stage 2) and failure (stage 3) groups based on their highest SCr, using the lowest SCr in the previous six... (More)
INTRODUCTION: Acute kidney injury (AKI) is a common problem in hospitalized patients, requiring extensive treatment and carries a high mortality rate. This study was designed to assess the epidemiology of AKI, and risk factors and outcome of patients with severe AKI in a tertiary care university hospital in Iceland.
MATERIAL AND METHODS: All adult patients with measured serum creatinine (SCr) in Landspitali University Hospital from January 2008 to December 2011, who had a measured baseline SCr in the preceeding six months, were included. Patients were categorized according to the RIFLE-criteria into risk (stage 1), injury (stage 2) and failure (stage 3) groups based on their highest SCr, using the lowest SCr in the previous six months as baseline.
RESULTS: A total of 17,693 individuals (out of 74,960) had a baseline SCr and their data were used for analysis. AKI occurred in 3,686 (21%) with 12%, 5% and 4% of stage 1, 2 and 3, respectively. There were more females in stage 1 and stage 2 and more males in stage 3 (p< 0.001). Contributing causes for AKI in patients with stage 3 AKI were surgery (22%), circulatory shock (23%), sepsis (14%), cardiovascular insult (32%), respiratory failure (27%), bleeding (10%), trauma (7%) and AKI associated drugs (61%). Dialysis was required in 11% and in 0.7% for longer than 30 days but none > 90 days. One year survival was 52%.
CONCLUSIONS: Acute kidney injury is common in Iceland and the prognosis of those with severe AKI is dismal. Majority of those patients were taking drugs that increase risk of AKI, providing a target for preventive measures.
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- author
- Long, Thorir Einarsson LU ; Sigurdsson, Martin Ingi ; Indridason, Olafur Skuli ; Sigvaldason, Kristinn and Sigurdsson, Gísli Heimir
- alternative title
- Epidemiology of acute kidney injury in a tertiary care university hospital according to the RIFLE criteria
- publishing date
- 2013-11
- type
- Contribution to journal
- publication status
- published
- keywords
- Acute Kidney Injury/blood, Aged, Aged, 80 and over, Biomarkers/blood, Creatinine/blood, Female, Hospitalization, Hospitals, University, Humans, Iceland/epidemiology, Kaplan-Meier Estimate, Male, Middle Aged, Prognosis, Risk Assessment, Risk Factors, Severity of Illness Index, Tertiary Care Centers, Time Factors
- in
- Laeknabladid
- volume
- 99
- issue
- 11
- pages
- 499 - 503
- publisher
- Læknafélag Íslands, Læknafélag Reykjavíkur
- external identifiers
-
- pmid:24287739
- scopus:84890537451
- ISSN
- 0023-7213
- DOI
- 10.17992/lbl.2013.11.516
- language
- Icelandic
- LU publication?
- no
- id
- 59d251d1-f0b8-4632-9f1d-5f32dfc77b57
- date added to LUP
- 2024-12-05 16:14:51
- date last changed
- 2025-01-03 05:59:47
@article{59d251d1-f0b8-4632-9f1d-5f32dfc77b57,
abstract = {{<p>INTRODUCTION: Acute kidney injury (AKI) is a common problem in hospitalized patients, requiring extensive treatment and carries a high mortality rate. This study was designed to assess the epidemiology of AKI, and risk factors and outcome of patients with severe AKI in a tertiary care university hospital in Iceland.</p><p>MATERIAL AND METHODS: All adult patients with measured serum creatinine (SCr) in Landspitali University Hospital from January 2008 to December 2011, who had a measured baseline SCr in the preceeding six months, were included. Patients were categorized according to the RIFLE-criteria into risk (stage 1), injury (stage 2) and failure (stage 3) groups based on their highest SCr, using the lowest SCr in the previous six months as baseline.</p><p>RESULTS: A total of 17,693 individuals (out of 74,960) had a baseline SCr and their data were used for analysis. AKI occurred in 3,686 (21%) with 12%, 5% and 4% of stage 1, 2 and 3, respectively. There were more females in stage 1 and stage 2 and more males in stage 3 (p< 0.001). Contributing causes for AKI in patients with stage 3 AKI were surgery (22%), circulatory shock (23%), sepsis (14%), cardiovascular insult (32%), respiratory failure (27%), bleeding (10%), trauma (7%) and AKI associated drugs (61%). Dialysis was required in 11% and in 0.7% for longer than 30 days but none > 90 days. One year survival was 52%.</p><p>CONCLUSIONS: Acute kidney injury is common in Iceland and the prognosis of those with severe AKI is dismal. Majority of those patients were taking drugs that increase risk of AKI, providing a target for preventive measures.</p>}},
author = {{Long, Thorir Einarsson and Sigurdsson, Martin Ingi and Indridason, Olafur Skuli and Sigvaldason, Kristinn and Sigurdsson, Gísli Heimir}},
issn = {{0023-7213}},
keywords = {{Acute Kidney Injury/blood; Aged; Aged, 80 and over; Biomarkers/blood; Creatinine/blood; Female; Hospitalization; Hospitals, University; Humans; Iceland/epidemiology; Kaplan-Meier Estimate; Male; Middle Aged; Prognosis; Risk Assessment; Risk Factors; Severity of Illness Index; Tertiary Care Centers; Time Factors}},
language = {{ice}},
number = {{11}},
pages = {{499--503}},
publisher = {{Læknafélag Íslands, Læknafélag Reykjavíkur}},
series = {{Laeknabladid}},
title = {{Bradur nyrnaskadi a Landspitala 2008-2011 og ahaettupaettir og afdrif sjuklinga med alvarlegan skada}},
url = {{http://dx.doi.org/10.17992/lbl.2013.11.516}},
doi = {{10.17992/lbl.2013.11.516}},
volume = {{99}},
year = {{2013}},
}