Characteristics and Long-term Prognosis of Danish Patients With Varicella Zoster Virus Detected in Cerebrospinal Fluid Compared With the Background Population
(2021) In The Journal of infectious diseases 224(5). p.850-859- Abstract
BACKGROUND: Risk factors for, and long-term outcomes following, detection of varicella zoster virus (VZV) DNA in the cerebrospinal fluid (CSF) are unknown. METHODS: We performed a nationwide population-based cohort study of all Danish residents who had VZV DNA detected in the CSF by polymerase chain reaction (PCR) between 1 January 1997 and 1 March 2016 (VZV cohort; n = 517) and an age- and sex- matched comparison cohort from the general Danish population (n = 9823). We examined potential risk factors and mortality, neurologic morbidity, psychiatric morbidity, redemptiom of prescriptions for nervous system medicine prescribed for the nervous system, and social outcomes. RESULTS: Prior hospital admission, redemption of immunosuppressive... (More)
BACKGROUND: Risk factors for, and long-term outcomes following, detection of varicella zoster virus (VZV) DNA in the cerebrospinal fluid (CSF) are unknown. METHODS: We performed a nationwide population-based cohort study of all Danish residents who had VZV DNA detected in the CSF by polymerase chain reaction (PCR) between 1 January 1997 and 1 March 2016 (VZV cohort; n = 517) and an age- and sex- matched comparison cohort from the general Danish population (n = 9823). We examined potential risk factors and mortality, neurologic morbidity, psychiatric morbidity, redemptiom of prescriptions for nervous system medicine prescribed for the nervous system, and social outcomes. RESULTS: Prior hospital admission, redemption of immunosuppressive medicine, comorbidity, and immunosuppressive conditions were associated with detection of VZV DNA in the CSF. Mortality was increased in the VZV cohort, especially during the first year of observation and among patients with encephalitis. Patients in the VZV cohort had an increased risk of dementia and epilepsy. The redemption of antiepileptics and antidepressants was increased in the VZV cohort. CONCLUSIONS: Immunosuppression and comorbidity are associated with increased risk of detection of VZV DNA in the CSF and the condition is associated with increased mortality and neurological morbidity.
(Less)
- author
- publishing date
- 2021-09-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- CNS infection, meningitis, varicella zoster virus
- in
- The Journal of infectious diseases
- volume
- 224
- issue
- 5
- pages
- 10 pages
- publisher
- Oxford University Press
- external identifiers
-
- pmid:33417703
- scopus:85116957716
- ISSN
- 1537-6613
- DOI
- 10.1093/infdis/jiab013
- language
- English
- LU publication?
- no
- additional info
- Publisher Copyright: © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
- id
- 5a04d9f9-4c5f-42e5-bfd2-6b91a8795f40
- date added to LUP
- 2021-11-23 15:00:51
- date last changed
- 2024-04-20 16:18:55
@article{5a04d9f9-4c5f-42e5-bfd2-6b91a8795f40,
abstract = {{<p>BACKGROUND: Risk factors for, and long-term outcomes following, detection of varicella zoster virus (VZV) DNA in the cerebrospinal fluid (CSF) are unknown. METHODS: We performed a nationwide population-based cohort study of all Danish residents who had VZV DNA detected in the CSF by polymerase chain reaction (PCR) between 1 January 1997 and 1 March 2016 (VZV cohort; n = 517) and an age- and sex- matched comparison cohort from the general Danish population (n = 9823). We examined potential risk factors and mortality, neurologic morbidity, psychiatric morbidity, redemptiom of prescriptions for nervous system medicine prescribed for the nervous system, and social outcomes. RESULTS: Prior hospital admission, redemption of immunosuppressive medicine, comorbidity, and immunosuppressive conditions were associated with detection of VZV DNA in the CSF. Mortality was increased in the VZV cohort, especially during the first year of observation and among patients with encephalitis. Patients in the VZV cohort had an increased risk of dementia and epilepsy. The redemption of antiepileptics and antidepressants was increased in the VZV cohort. CONCLUSIONS: Immunosuppression and comorbidity are associated with increased risk of detection of VZV DNA in the CSF and the condition is associated with increased mortality and neurological morbidity.</p>}},
author = {{Omland, Lars H. and Vestergaard, Hanne T. and Dessau, Ram B. and Bodilsen, Jacob and Andersen, Nanna S. and Christiansen, Claus B. and Ellermann-Eriksen, Svend and Nielsen, Lene and Andersen, Christian and Lebech, Anne Mette and Obel, Niels}},
issn = {{1537-6613}},
keywords = {{CNS infection; meningitis; varicella zoster virus}},
language = {{eng}},
month = {{09}},
number = {{5}},
pages = {{850--859}},
publisher = {{Oxford University Press}},
series = {{The Journal of infectious diseases}},
title = {{Characteristics and Long-term Prognosis of Danish Patients With Varicella Zoster Virus Detected in Cerebrospinal Fluid Compared With the Background Population}},
url = {{http://dx.doi.org/10.1093/infdis/jiab013}},
doi = {{10.1093/infdis/jiab013}},
volume = {{224}},
year = {{2021}},
}