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Synaptic memories upside down: bidirectional plasticity at cerebellar parallel fiber-purkinje cell synapses.

Jörntell, Henrik LU and Hansel, Christian (2006) In Neuron 52(2). p.227-238
Abstract
Information storage in neural circuits depends on activity-dependent alterations in synaptic weights, such as long-term potentiation (LTP) and long-term depression (LTD). Bidirectional synaptic plasticity endows synapses with mechanisms for rapid reversibility, but it remains unclear how it correlates with reversibility in behavioral learning and whether there is a universal synaptic memory mechanism that operates similarly at all types of synapses. A recently discovered postsynaptic form of LTP at cerebellar parallel fiber (PF)-Purkinje cell (PC) synapses provides a reversal mechanism for PF-LTD and enables a fresh look at the implications of bidirectional plasticity in a brain structure that is particularly suitable to correlate cellular... (More)
Information storage in neural circuits depends on activity-dependent alterations in synaptic weights, such as long-term potentiation (LTP) and long-term depression (LTD). Bidirectional synaptic plasticity endows synapses with mechanisms for rapid reversibility, but it remains unclear how it correlates with reversibility in behavioral learning and whether there is a universal synaptic memory mechanism that operates similarly at all types of synapses. A recently discovered postsynaptic form of LTP at cerebellar parallel fiber (PF)-Purkinje cell (PC) synapses provides a reversal mechanism for PF-LTD and enables a fresh look at the implications of bidirectional plasticity in a brain structure that is particularly suitable to correlate cellular to behavioral learning events. Here, we will review recent studies that reveal unique properties of bidirectional cerebellar plasticity and suggest that the induction cascades for cerebellar LTP and LTD provide a mirror image of their counterparts at hippocampal synapses. We will also discuss how PF-LTP helps to explain reversibility observed in cerebellar motor learning. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neuron
volume
52
issue
2
pages
227 - 238
publisher
Cell Press
external identifiers
  • wos:000241799900004
  • scopus:33749595411
ISSN
0896-6273
DOI
10.1016/j.neuron.2006.09.032
language
English
LU publication?
yes
id
5a1c7ca2-c908-40a1-b3bf-d0290fcc428f (old id 162296)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17046686&dopt=Abstract
date added to LUP
2007-07-16 10:44:54
date last changed
2019-10-23 02:32:56
@article{5a1c7ca2-c908-40a1-b3bf-d0290fcc428f,
  abstract     = {Information storage in neural circuits depends on activity-dependent alterations in synaptic weights, such as long-term potentiation (LTP) and long-term depression (LTD). Bidirectional synaptic plasticity endows synapses with mechanisms for rapid reversibility, but it remains unclear how it correlates with reversibility in behavioral learning and whether there is a universal synaptic memory mechanism that operates similarly at all types of synapses. A recently discovered postsynaptic form of LTP at cerebellar parallel fiber (PF)-Purkinje cell (PC) synapses provides a reversal mechanism for PF-LTD and enables a fresh look at the implications of bidirectional plasticity in a brain structure that is particularly suitable to correlate cellular to behavioral learning events. Here, we will review recent studies that reveal unique properties of bidirectional cerebellar plasticity and suggest that the induction cascades for cerebellar LTP and LTD provide a mirror image of their counterparts at hippocampal synapses. We will also discuss how PF-LTP helps to explain reversibility observed in cerebellar motor learning.},
  author       = {Jörntell, Henrik and Hansel, Christian},
  issn         = {0896-6273},
  language     = {eng},
  number       = {2},
  pages        = {227--238},
  publisher    = {Cell Press},
  series       = {Neuron},
  title        = {Synaptic memories upside down: bidirectional plasticity at cerebellar parallel fiber-purkinje cell synapses.},
  url          = {http://dx.doi.org/10.1016/j.neuron.2006.09.032},
  volume       = {52},
  year         = {2006},
}