Future drugs for the treatment of benign prostatic hyperplasia.
Andersson, Karl-Erik LU
; Chapple, C R
and Höfner, K
(2002)
In World Journal of Urology
19(6).
p.436-442
- Abstract
- For at least a decade, no new drug principles have been added to the therapeutic armamentarium for the treatment of lower urinary tract symptoms (LUTS) associated with or suggestive of benign prostatic hyperplasia (BPH). Theoretically, there seem to be several possibilities to improve the current treatment, which is based mainly on alpha1-adrenoceptor (AR) antagonists, 5alpha-reductase inhibitors and phytotherapy. It cannot be dismissed that subtype selective alpha1-AR antagonists can further improve treatment, but convincing evidence is still lacking. Muscarinic receptor antagonists are currently evaluated in BPH patients, but their eventual place in therapy, as a single treatment or in combination with alpha1-AR antagonists, has to be... (More)
- For at least a decade, no new drug principles have been added to the therapeutic armamentarium for the treatment of lower urinary tract symptoms (LUTS) associated with or suggestive of benign prostatic hyperplasia (BPH). Theoretically, there seem to be several possibilities to improve the current treatment, which is based mainly on alpha1-adrenoceptor (AR) antagonists, 5alpha-reductase inhibitors and phytotherapy. It cannot be dismissed that subtype selective alpha1-AR antagonists can further improve treatment, but convincing evidence is still lacking. Muscarinic receptor antagonists are currently evaluated in BPH patients, but their eventual place in therapy, as a single treatment or in combination with alpha1-AR antagonists, has to be established. Endothelin receptor antagonists, alone or together with alpha1-AR antagonists, seem to offer a new attractive approach; however, proof of concept studies are lacking. The L-arginine/NO/cGMP pathway awaits further exploration; nitric oxide (NO) donors or phosphodiesterase (PDE) inhibitors may be clinically useful. Purinoceptors are currently the focus of interest as treatment targets in the lower urinary tract and inhibitors of P2X3 (and P2X1) subtypes may offer new opportunities. If a treatment based on desensitising C-fibres in the bladder and urethra is effective, not only in neurogenic bladders, but also for treating LUTS, it would be a viable option. For new treatments of LUTS, targets within the central nervous system (CNS) may offer exciting opportunities. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/108366
- author
- Andersson, Karl-Erik
LU
; Chapple, C R
and Höfner, K
- organization
- publishing date
- 2002
- type
- Contribution to journal
- publication status
- published
- subject
- in
- World Journal of Urology
- volume
- 19
- issue
- 6
- pages
- 436 - 442
- publisher
- Springer
- external identifiers
-
- wos:000175498900007
- pmid:12022712
- scopus:0036549787
- ISSN
- 1433-8726
- DOI
- 10.1007/s00345-002-0253-8
- language
- English
- LU publication?
- yes
- id
- 5a272713-76be-4c48-9435-f2142d6d690d (old id 108366)
- date added to LUP
- 2016-04-01 16:21:34
- date last changed
- 2022-01-28 19:06:53
@article{5a272713-76be-4c48-9435-f2142d6d690d,
abstract = {{For at least a decade, no new drug principles have been added to the therapeutic armamentarium for the treatment of lower urinary tract symptoms (LUTS) associated with or suggestive of benign prostatic hyperplasia (BPH). Theoretically, there seem to be several possibilities to improve the current treatment, which is based mainly on alpha1-adrenoceptor (AR) antagonists, 5alpha-reductase inhibitors and phytotherapy. It cannot be dismissed that subtype selective alpha1-AR antagonists can further improve treatment, but convincing evidence is still lacking. Muscarinic receptor antagonists are currently evaluated in BPH patients, but their eventual place in therapy, as a single treatment or in combination with alpha1-AR antagonists, has to be established. Endothelin receptor antagonists, alone or together with alpha1-AR antagonists, seem to offer a new attractive approach; however, proof of concept studies are lacking. The L-arginine/NO/cGMP pathway awaits further exploration; nitric oxide (NO) donors or phosphodiesterase (PDE) inhibitors may be clinically useful. Purinoceptors are currently the focus of interest as treatment targets in the lower urinary tract and inhibitors of P2X3 (and P2X1) subtypes may offer new opportunities. If a treatment based on desensitising C-fibres in the bladder and urethra is effective, not only in neurogenic bladders, but also for treating LUTS, it would be a viable option. For new treatments of LUTS, targets within the central nervous system (CNS) may offer exciting opportunities.}},
author = {{Andersson, Karl-Erik and Chapple, C R and Höfner, K}},
issn = {{1433-8726}},
language = {{eng}},
number = {{6}},
pages = {{436--442}},
publisher = {{Springer}},
series = {{World Journal of Urology}},
title = {{Future drugs for the treatment of benign prostatic hyperplasia.}},
url = {{http://dx.doi.org/10.1007/s00345-002-0253-8}},
doi = {{10.1007/s00345-002-0253-8}},
volume = {{19}},
year = {{2002}},
}