Immunocytochemical analysis of amyloid precursor protein and its derivatives
Gouras, Gunnar LU
and Takahashi, Reisuke H.
(2004)
p.155-164
- Abstract
Histochemical analysis of postmortem human brains from subjects who suffered from dementia led to the discovery of Alzheimer’s disease a century ago. The histological lesions that characterized this common age-related dementia were the accumulation of senile plaques (SPs) and neurofibrillary tangles (NFTs). Subsequently, NFTs were found in a variety of degenerative diseases of the brain, while plaques remained more unique to Alzheimer’s dementia. The biochemical analysis of plaques in the 1980s led first to the identification of the fundamental componentof plaques, the β -amyloid peptide (A β), 1 followed by the identification of its longer precursor protein, the amyloid precursor protein (APP). 2.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/5a454015-4f86-44e5-93cf-0bb694bd8463
- author
- Gouras, Gunnar
LU
and Takahashi, Reisuke H.
- publishing date
- 2004-01-01
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- Amyloid Precursor Protein : A Practical Approach - A Practical Approach
- pages
- 10 pages
- publisher
- CRC Press/Balkema
- external identifiers
-
- scopus:77953022995
- ISBN
- 9780203492185
- 9780849322457
- language
- English
- LU publication?
- no
- id
- 5a454015-4f86-44e5-93cf-0bb694bd8463
- date added to LUP
- 2020-02-20 14:24:54
- date last changed
- 2024-06-26 12:00:17
@inbook{5a454015-4f86-44e5-93cf-0bb694bd8463,
abstract = {{<p>Histochemical analysis of postmortem human brains from subjects who suffered from dementia led to the discovery of Alzheimer’s disease a century ago. The histological lesions that characterized this common age-related dementia were the accumulation of senile plaques (SPs) and neurofibrillary tangles (NFTs). Subsequently, NFTs were found in a variety of degenerative diseases of the brain, while plaques remained more unique to Alzheimer’s dementia. The biochemical analysis of plaques in the 1980s led first to the identification of the fundamental componentof plaques, the β -amyloid peptide (A β), 1 followed by the identification of its longer precursor protein, the amyloid precursor protein (APP). 2.</p>}},
author = {{Gouras, Gunnar and Takahashi, Reisuke H.}},
booktitle = {{Amyloid Precursor Protein : A Practical Approach}},
isbn = {{9780203492185}},
language = {{eng}},
month = {{01}},
pages = {{155--164}},
publisher = {{CRC Press/Balkema}},
title = {{Immunocytochemical analysis of amyloid precursor protein and its derivatives}},
year = {{2004}},
}