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Nerve regeneration and serum levels of insulin-like growth factor-I in rats with streptozotocin-induced insulin deficiency

Ekström, Per A R LU ; Kanje, Martin LU and Skottner, Anna (1989) In Brain Research 496(1-2). p.141-147
Abstract

Peripheral nerve regeneration was studied in female Sprague-Dawley rats with streptozotocin-induced insulin deficiency. Nerve regeneration was provoked by a crush lesion on the sciatic nerve 21 days after the streptozotocin injection. The regeneration was assessed by a pinch test at different time-points after injury. The rate ofregeneration in insulin-deficient animals, 2.5 mm/day, was significantly lower than in control animals, 2.9 mm/day(P < 0.05). There was no difference in the initial delay, i.e. the period before regeneration attains a constant velocity. One group of insulin-deficient rats was treated with insulin during the regeneration period by means of implanted osmotic mini-pumps. This treatment prevented the decrease in... (More)

Peripheral nerve regeneration was studied in female Sprague-Dawley rats with streptozotocin-induced insulin deficiency. Nerve regeneration was provoked by a crush lesion on the sciatic nerve 21 days after the streptozotocin injection. The regeneration was assessed by a pinch test at different time-points after injury. The rate ofregeneration in insulin-deficient animals, 2.5 mm/day, was significantly lower than in control animals, 2.9 mm/day(P < 0.05). There was no difference in the initial delay, i.e. the period before regeneration attains a constant velocity. One group of insulin-deficient rats was treated with insulin during the regeneration period by means of implanted osmotic mini-pumps. This treatment prevented the decrease in regenerationsw. After 6 days the sciatic nerves of insulin-deficient rats had regenerated 12.3 ±0.3 mm (mean ±S.E.M.), while the corresponding value for insulin-treated rats was 15.7 ±0.6 mm (P > 0.01). The streptozotocin-treated rats were found to have a 39% reduction in the serum level of insulin-like 1 growth factor-I (IGF-I)_compared to control rats (0.33 ± 0.22 μg/ml and 0.54 ± ml respectively, (P < 0.001). Insulin treatment 1830 1732 during the regeneration period completely restored the IGF-I level back to normal.

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Diabetes, Insulin, Insulin-like growth factor-I, Nerve regeneration, Rat, Sciatic nerve, Somatomedin, Streptozotocin
in
Brain Research
volume
496
issue
1-2
pages
141 - 147
publisher
Elsevier
external identifiers
  • pmid:2529948
  • scopus:0024340849
ISSN
0006-8993
DOI
10.1016/0006-8993(89)91060-3
language
English
LU publication?
yes
id
5a49e4bb-fc17-4fbf-ac9a-b6ecf5aba1cf
date added to LUP
2016-12-07 14:31:47
date last changed
2025-10-14 11:07:22
@article{5a49e4bb-fc17-4fbf-ac9a-b6ecf5aba1cf,
  abstract     = {{<p>Peripheral nerve regeneration was studied in female Sprague-Dawley rats with streptozotocin-induced insulin deficiency. Nerve regeneration was provoked by a crush lesion on the sciatic nerve 21 days after the streptozotocin injection. The regeneration was assessed by a pinch test at different time-points after injury. The rate ofregeneration in insulin-deficient animals, 2.5 mm/day, was significantly lower than in control animals, 2.9 mm/day(P &lt; 0.05). There was no difference in the initial delay, i.e. the period before regeneration attains a constant velocity. One group of insulin-deficient rats was treated with insulin during the regeneration period by means of implanted osmotic mini-pumps. This treatment prevented the decrease in regenerationsw. After 6 days the sciatic nerves of insulin-deficient rats had regenerated 12.3 ±0.3 mm (mean ±S.E.M.), while the corresponding value for insulin-treated rats was 15.7 ±0.6 mm (P &gt; 0.01). The streptozotocin-treated rats were found to have a 39% reduction in the serum level of insulin-like 1 growth factor-I (IGF-I)_compared to control rats (0.33 ± 0.22 μg/ml and 0.54 ± ml respectively, (P &lt; 0.001). Insulin treatment 1830 1732 during the regeneration period completely restored the IGF-I level back to normal.</p>}},
  author       = {{Ekström, Per A R and Kanje, Martin and Skottner, Anna}},
  issn         = {{0006-8993}},
  keywords     = {{Diabetes; Insulin; Insulin-like growth factor-I; Nerve regeneration; Rat; Sciatic nerve; Somatomedin; Streptozotocin}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{1-2}},
  pages        = {{141--147}},
  publisher    = {{Elsevier}},
  series       = {{Brain Research}},
  title        = {{Nerve regeneration and serum levels of insulin-like growth factor-I in rats with streptozotocin-induced insulin deficiency}},
  url          = {{http://dx.doi.org/10.1016/0006-8993(89)91060-3}},
  doi          = {{10.1016/0006-8993(89)91060-3}},
  volume       = {{496}},
  year         = {{1989}},
}