In situ identification and G4-PPI-His-Mal-dendrimer-induced reduction of early-stage amyloid aggregates in Alzheimer’s disease transgenic mice using synchrotron-based infrared imaging
Benseny-Cases, Núria ; Álvarez-Marimon, Elena ; Aso, Ester ; Carmona, Margarita ; Klementieva, Oxana LU
; Appelhans, Dietmar
; Ferrer, Isidre
and Cladera, Josep
(2021)
In Scientific Reports
11(1).
- Abstract
Amyloid plaques composed of Aβ amyloid peptides and neurofibrillary tangles are a pathological hallmark of Alzheimer Disease. In situ identification of early-stage amyloid aggregates in Alzheimer’s disease is relevant for their importance as potential targets for effective drugs. Synchrotron-based infrared imaging is here used to identify early-stage oligomeric/granular aggregated amyloid species in situ in the brain of APP/PS1 transgenic mice for the first time. Also, APP/PS1 mice show fibrillary aggregates at 6 and 12 months. A significant decreased burden of early-stage aggregates and fibrillary aggregates is obtained following treatment with poly(propylene imine) dendrimers with histidine-maltose shell (a neurodegenerative... (More)
Amyloid plaques composed of Aβ amyloid peptides and neurofibrillary tangles are a pathological hallmark of Alzheimer Disease. In situ identification of early-stage amyloid aggregates in Alzheimer’s disease is relevant for their importance as potential targets for effective drugs. Synchrotron-based infrared imaging is here used to identify early-stage oligomeric/granular aggregated amyloid species in situ in the brain of APP/PS1 transgenic mice for the first time. Also, APP/PS1 mice show fibrillary aggregates at 6 and 12 months. A significant decreased burden of early-stage aggregates and fibrillary aggregates is obtained following treatment with poly(propylene imine) dendrimers with histidine-maltose shell (a neurodegenerative protector) in 6-month-old APP/PS1 mice, thus demonstrating their putative therapeutic properties of in AD models. Identification, localization, and characterization using infrared imaging of these non-fibrillary species in the cerebral cortex at early stages of AD progression in transgenic mice point to their relevance as putative pharmacological targets. No less important, early detection of these structures may be useful in the search for markers for non-invasive diagnostic techniques.
(Less)
- author
- Benseny-Cases, Núria
; Álvarez-Marimon, Elena
; Aso, Ester
; Carmona, Margarita
; Klementieva, Oxana
LU
; Appelhans, Dietmar
; Ferrer, Isidre
and Cladera, Josep
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 11
- issue
- 1
- article number
- 18368
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85115234736
- pmid:34526539
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-021-96379-4
- language
- English
- LU publication?
- yes
- id
- 5a5933bd-6a4c-46cd-ad7a-ef512271b5d8
- date added to LUP
- 2021-10-01 11:55:55
- date last changed
- 2024-09-22 02:11:29
@article{5a5933bd-6a4c-46cd-ad7a-ef512271b5d8,
abstract = {{<p>Amyloid plaques composed of Aβ amyloid peptides and neurofibrillary tangles are a pathological hallmark of Alzheimer Disease. In situ identification of early-stage amyloid aggregates in Alzheimer’s disease is relevant for their importance as potential targets for effective drugs. Synchrotron-based infrared imaging is here used to identify early-stage oligomeric/granular aggregated amyloid species in situ in the brain of APP/PS1 transgenic mice for the first time. Also, APP/PS1 mice show fibrillary aggregates at 6 and 12 months. A significant decreased burden of early-stage aggregates and fibrillary aggregates is obtained following treatment with poly(propylene imine) dendrimers with histidine-maltose shell (a neurodegenerative protector) in 6-month-old APP/PS1 mice, thus demonstrating their putative therapeutic properties of in AD models. Identification, localization, and characterization using infrared imaging of these non-fibrillary species in the cerebral cortex at early stages of AD progression in transgenic mice point to their relevance as putative pharmacological targets. No less important, early detection of these structures may be useful in the search for markers for non-invasive diagnostic techniques.</p>}},
author = {{Benseny-Cases, Núria and Álvarez-Marimon, Elena and Aso, Ester and Carmona, Margarita and Klementieva, Oxana and Appelhans, Dietmar and Ferrer, Isidre and Cladera, Josep}},
issn = {{2045-2322}},
language = {{eng}},
number = {{1}},
publisher = {{Nature Publishing Group}},
series = {{Scientific Reports}},
title = {{In situ identification and G4-PPI-His-Mal-dendrimer-induced reduction of early-stage amyloid aggregates in Alzheimer’s disease transgenic mice using synchrotron-based infrared imaging}},
url = {{http://dx.doi.org/10.1038/s41598-021-96379-4}},
doi = {{10.1038/s41598-021-96379-4}},
volume = {{11}},
year = {{2021}},
}