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Immunobiology of T helper cells and antigen-presenting cells in autoimmune thrombocytopenic purpura (ITP)

Semple, J W LU (1998) In Acta Paediatrica, International Journal of Paediatrics, Supplement 424. p.5-41
Abstract

Autoimmune thrombocytopenic purpura (AITP) is a bleeding disease in which autoantibodies are directed against the individual's own platelets, resulting in enhanced Fc-mediated platelet destruction by macrophages in the reticuloendothelial system. Most research in AITP has focused on characterization of the autoantibodies, while little has been devoted to the cellular immune mechanisms leading to autoantibody production. This report summarizes the current state of the literature and argues that enhanced T helper cell/antigen-presenting cell interactions in patients with AITP are the primary stimulus for the development of antiplatelet autoantibody production. Understanding these events is important for eventually identifying... (More)

Autoimmune thrombocytopenic purpura (AITP) is a bleeding disease in which autoantibodies are directed against the individual's own platelets, resulting in enhanced Fc-mediated platelet destruction by macrophages in the reticuloendothelial system. Most research in AITP has focused on characterization of the autoantibodies, while little has been devoted to the cellular immune mechanisms leading to autoantibody production. This report summarizes the current state of the literature and argues that enhanced T helper cell/antigen-presenting cell interactions in patients with AITP are the primary stimulus for the development of antiplatelet autoantibody production. Understanding these events is important for eventually identifying disease-initiating platelet autoantigens and ultimately developing specific immunotherapies for AITP.

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Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Antigen-Presenting Cells/immunology, Autoantigens/immunology, Blood Platelets/immunology, Humans, Immunity, Cellular/immunology, Purpura, Thrombocytopenic, Idiopathic/immunology, T-Lymphocytes, Helper-Inducer/immunology
in
Acta Paediatrica, International Journal of Paediatrics, Supplement
volume
424
pages
5 - 41
publisher
Scandinavian University Press
external identifiers
  • scopus:0031663468
  • pmid:9736217
ISSN
0803-5326
DOI
10.1111/j.1651-2227.1998.tb01232.x
language
English
LU publication?
no
id
5a82c618-6dab-4a6a-9b7a-206409b5cdc9
date added to LUP
2022-11-09 15:28:11
date last changed
2024-01-03 10:07:58
@article{5a82c618-6dab-4a6a-9b7a-206409b5cdc9,
  abstract     = {{<p>Autoimmune thrombocytopenic purpura (AITP) is a bleeding disease in which autoantibodies are directed against the individual's own platelets, resulting in enhanced Fc-mediated platelet destruction by macrophages in the reticuloendothelial system. Most research in AITP has focused on characterization of the autoantibodies, while little has been devoted to the cellular immune mechanisms leading to autoantibody production. This report summarizes the current state of the literature and argues that enhanced T helper cell/antigen-presenting cell interactions in patients with AITP are the primary stimulus for the development of antiplatelet autoantibody production. Understanding these events is important for eventually identifying disease-initiating platelet autoantigens and ultimately developing specific immunotherapies for AITP.</p>}},
  author       = {{Semple, J W}},
  issn         = {{0803-5326}},
  keywords     = {{Antigen-Presenting Cells/immunology; Autoantigens/immunology; Blood Platelets/immunology; Humans; Immunity, Cellular/immunology; Purpura, Thrombocytopenic, Idiopathic/immunology; T-Lymphocytes, Helper-Inducer/immunology}},
  language     = {{eng}},
  pages        = {{5--41}},
  publisher    = {{Scandinavian University Press}},
  series       = {{Acta Paediatrica, International Journal of Paediatrics, Supplement}},
  title        = {{Immunobiology of T helper cells and antigen-presenting cells in autoimmune thrombocytopenic purpura (ITP)}},
  url          = {{http://dx.doi.org/10.1111/j.1651-2227.1998.tb01232.x}},
  doi          = {{10.1111/j.1651-2227.1998.tb01232.x}},
  volume       = {{424}},
  year         = {{1998}},
}