Advanced

On the mechanistic origin of damped oscillations in biochemical reaction systems

Ryde-Pettersson, Ulf LU (1990) In European Journal of Biochemistry 194(2). p.431-436
Abstract

A generalized reaction scheme for the kinetic interaction of two reactants in a metabolic pathway has been examined in order to establish what minimal mechanistic patterns are required to support a damped oscillatory transient‐state kinetic behaviour of such a two‐component system when operating near a steady state. All potentially oscillating sub‐systems inherent in this scheme are listed and briefly characterized. The list includes several mechanistic patterns that may be frequently encountered in biological system (e.g. involving feedback inhibition, feed‐forward activation, substrate inhibition or product activation), but also draw attention to some hitherto unforeseen mechanisms by which the kinetic interaction of two metabolites... (More)

A generalized reaction scheme for the kinetic interaction of two reactants in a metabolic pathway has been examined in order to establish what minimal mechanistic patterns are required to support a damped oscillatory transient‐state kinetic behaviour of such a two‐component system when operating near a steady state. All potentially oscillating sub‐systems inherent in this scheme are listed and briefly characterized. The list includes several mechanistic patterns that may be frequently encountered in biological system (e.g. involving feedback inhibition, feed‐forward activation, substrate inhibition or product activation), but also draw attention to some hitherto unforeseen mechanisms by which the kinetic interaction of two metabolites may trigger damped oscillations. The results can be used to identify possible sources of oscillations in metabolic pathways without detailed knowledge about the explicit rate equations that apply. Copyright © 1990, Wiley Blackwell. All rights reserved

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Biochemistry
volume
194
issue
2
pages
6 pages
publisher
Wiley-Blackwell
external identifiers
  • Scopus:0025615914
ISSN
0014-2956
DOI
10.1111/j.1432-1033.1990.tb15636.x
language
English
LU publication?
yes
id
5a848c45-2aa2-41eb-b465-67ad9cc81034
date added to LUP
2017-02-04 11:23:16
date last changed
2017-03-06 16:23:00
@article{5a848c45-2aa2-41eb-b465-67ad9cc81034,
  abstract     = {<p>A generalized reaction scheme for the kinetic interaction of two reactants in a metabolic pathway has been examined in order to establish what minimal mechanistic patterns are required to support a damped oscillatory transient‐state kinetic behaviour of such a two‐component system when operating near a steady state. All potentially oscillating sub‐systems inherent in this scheme are listed and briefly characterized. The list includes several mechanistic patterns that may be frequently encountered in biological system (e.g. involving feedback inhibition, feed‐forward activation, substrate inhibition or product activation), but also draw attention to some hitherto unforeseen mechanisms by which the kinetic interaction of two metabolites may trigger damped oscillations. The results can be used to identify possible sources of oscillations in metabolic pathways without detailed knowledge about the explicit rate equations that apply. Copyright © 1990, Wiley Blackwell. All rights reserved</p>},
  author       = {Ryde-Pettersson, Ulf},
  issn         = {0014-2956},
  language     = {eng},
  number       = {2},
  pages        = {431--436},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Biochemistry},
  title        = {On the mechanistic origin of damped oscillations in biochemical reaction systems},
  url          = {http://dx.doi.org/10.1111/j.1432-1033.1990.tb15636.x},
  volume       = {194},
  year         = {1990},
}