The Aldose Reductase Inhibitor Fidarestat Suppresses Ischemia-Reperfusion-Induced Inflammatory Response in Rat Retina.
(2009) In Pharmacology 84(5). p.257-263- Abstract
- Recent studies suggest that increased aldose reductase (AR) activity plays an important role in ischemia-reperfusion injury in the retina. The mechanisms are not completely understood, but may be linked to inflammation. In the present study, we investigated whether the AR inhibitor fidarestat suppressed the retinal inflammatory response induced by ischemia-reperfusion in a rat model. The inflammatory response was manifested by increased gene expression of tumor necrosis factor-alpha and intercellular adhesion molecule-1 (ICAM-1) as well as elevated protein levels of soluble ICAM-1. This response was partially suppressed by the AR inhibitor fidarestat. The findings may reveal beneficial effects of AR inhibition on retinal inflammation... (More)
- Recent studies suggest that increased aldose reductase (AR) activity plays an important role in ischemia-reperfusion injury in the retina. The mechanisms are not completely understood, but may be linked to inflammation. In the present study, we investigated whether the AR inhibitor fidarestat suppressed the retinal inflammatory response induced by ischemia-reperfusion in a rat model. The inflammatory response was manifested by increased gene expression of tumor necrosis factor-alpha and intercellular adhesion molecule-1 (ICAM-1) as well as elevated protein levels of soluble ICAM-1. This response was partially suppressed by the AR inhibitor fidarestat. The findings may reveal beneficial effects of AR inhibition on retinal inflammation associated with ischemia-reperfusion and are in agreement with recent developments in pharmacological research suggesting that pathological conditions other than diabetes may benefit from AR inhibitors. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1483218
- author
- Agardh, Carl-David LU ; Agardh, Elisabet LU ; Obrosova, Irina G and Smith, Maj-Lis LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aldose reductase inhibitor, Fidarestat, Inflammation, Retina, Rat
- in
- Pharmacology
- volume
- 84
- issue
- 5
- pages
- 257 - 263
- publisher
- Karger
- external identifiers
-
- wos:000271024400001
- pmid:19776662
- scopus:70349261110
- ISSN
- 1423-0313
- DOI
- 10.1159/000241733
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Unit on Vascular Diabetic Complications (013241510)
- id
- 5ad55161-ba04-4abe-bbaa-225d31f22fc7 (old id 1483218)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19776662?dopt=Abstract
- date added to LUP
- 2016-04-01 12:30:01
- date last changed
- 2022-01-27 05:54:18
@article{5ad55161-ba04-4abe-bbaa-225d31f22fc7, abstract = {{Recent studies suggest that increased aldose reductase (AR) activity plays an important role in ischemia-reperfusion injury in the retina. The mechanisms are not completely understood, but may be linked to inflammation. In the present study, we investigated whether the AR inhibitor fidarestat suppressed the retinal inflammatory response induced by ischemia-reperfusion in a rat model. The inflammatory response was manifested by increased gene expression of tumor necrosis factor-alpha and intercellular adhesion molecule-1 (ICAM-1) as well as elevated protein levels of soluble ICAM-1. This response was partially suppressed by the AR inhibitor fidarestat. The findings may reveal beneficial effects of AR inhibition on retinal inflammation associated with ischemia-reperfusion and are in agreement with recent developments in pharmacological research suggesting that pathological conditions other than diabetes may benefit from AR inhibitors.}}, author = {{Agardh, Carl-David and Agardh, Elisabet and Obrosova, Irina G and Smith, Maj-Lis}}, issn = {{1423-0313}}, keywords = {{Aldose reductase inhibitor; Fidarestat; Inflammation; Retina; Rat}}, language = {{eng}}, number = {{5}}, pages = {{257--263}}, publisher = {{Karger}}, series = {{Pharmacology}}, title = {{The Aldose Reductase Inhibitor Fidarestat Suppresses Ischemia-Reperfusion-Induced Inflammatory Response in Rat Retina.}}, url = {{http://dx.doi.org/10.1159/000241733}}, doi = {{10.1159/000241733}}, volume = {{84}}, year = {{2009}}, }