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Systemic CD4+ T-cell activation is correlated with FEV(1) in smokers.

Glader, Pernilla LU ; von Wachenfeldt, Karin and Löfdahl, Claes-Göran LU (2006) In Respiratory Medicine 100(6). p.1088-1093
Abstract
The inflammation of the lungs in chronic obstructive pulmonary disease (COPD) is characterised by increased numbers of macrophages, neutrophils and T-cells. Decline in lung function in these patients has been correlated to the number of CD8+ T-cells present in the lung as well as to a decline in the ratio of CD4+/CD8+ T-cells. Although systemic components are likely to be present, circulating lymphocyte populations in COPD patients have not been well characterised. This study aimed at correlating lung function to expression of five different T-cell activation markers on peripheral blood CD4+ and CD8+ T-cells in COPD patients and matched smokers. Furthermore, proportions of lymphocyte populations and degree of systemic T-cell activation in... (More)
The inflammation of the lungs in chronic obstructive pulmonary disease (COPD) is characterised by increased numbers of macrophages, neutrophils and T-cells. Decline in lung function in these patients has been correlated to the number of CD8+ T-cells present in the lung as well as to a decline in the ratio of CD4+/CD8+ T-cells. Although systemic components are likely to be present, circulating lymphocyte populations in COPD patients have not been well characterised. This study aimed at correlating lung function to expression of five different T-cell activation markers on peripheral blood CD4+ and CD8+ T-cells in COPD patients and matched smokers. Furthermore, proportions of lymphocyte populations and degree of systemic T-cell activation in COPD patients were compared to that in smokers and never-smokers. Peripheral blood lymphocytes from six never-smokers, eight smokers and 17 smokers with COPD were analysed using flowcytometry. The number of lymphocytes per millilitre was higher in smokers than in never-smokers. No differences were found between the three groups in regard to proportions of lymphocyte populations, but the number of CD4+ T-cells in smokers was higher than in both never-smokers and COPD patients. The degree of T-cell activation was similar in all patient groups; however, a clear correlation between CD69 expression on CD4+ T-cells and lung function (FEV1% of predicted) was found when examining current smokers, with or without COPD. Elevated numbers of CD69+ CD4+ T-cells in blood thus seem to be protective against airway obstruction in smokers while still exposed to cigarette smoke, the main inducer of COPD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Lymphocytes, FEV1, Chronic obstructive pulmonary disease, Lung function, CD69, T-cells
in
Respiratory Medicine
volume
100
issue
6
pages
1088 - 1093
publisher
Elsevier
external identifiers
  • wos:000238016500018
  • scopus:33646056128
ISSN
1532-3064
DOI
10.1016/j.rmed.2005.09.025
language
English
LU publication?
yes
id
5ae7b43b-424e-4cb2-b8db-08bd0f07872f (old id 144443)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16246539&dopt=Abstract
date added to LUP
2007-07-11 10:34:42
date last changed
2019-04-23 03:10:58
@article{5ae7b43b-424e-4cb2-b8db-08bd0f07872f,
  abstract     = {The inflammation of the lungs in chronic obstructive pulmonary disease (COPD) is characterised by increased numbers of macrophages, neutrophils and T-cells. Decline in lung function in these patients has been correlated to the number of CD8+ T-cells present in the lung as well as to a decline in the ratio of CD4+/CD8+ T-cells. Although systemic components are likely to be present, circulating lymphocyte populations in COPD patients have not been well characterised. This study aimed at correlating lung function to expression of five different T-cell activation markers on peripheral blood CD4+ and CD8+ T-cells in COPD patients and matched smokers. Furthermore, proportions of lymphocyte populations and degree of systemic T-cell activation in COPD patients were compared to that in smokers and never-smokers. Peripheral blood lymphocytes from six never-smokers, eight smokers and 17 smokers with COPD were analysed using flowcytometry. The number of lymphocytes per millilitre was higher in smokers than in never-smokers. No differences were found between the three groups in regard to proportions of lymphocyte populations, but the number of CD4+ T-cells in smokers was higher than in both never-smokers and COPD patients. The degree of T-cell activation was similar in all patient groups; however, a clear correlation between CD69 expression on CD4+ T-cells and lung function (FEV1% of predicted) was found when examining current smokers, with or without COPD. Elevated numbers of CD69+ CD4+ T-cells in blood thus seem to be protective against airway obstruction in smokers while still exposed to cigarette smoke, the main inducer of COPD.},
  author       = {Glader, Pernilla and von Wachenfeldt, Karin and Löfdahl, Claes-Göran},
  issn         = {1532-3064},
  keyword      = {Lymphocytes,FEV1,Chronic obstructive pulmonary disease,Lung function,CD69,T-cells},
  language     = {eng},
  number       = {6},
  pages        = {1088--1093},
  publisher    = {Elsevier},
  series       = {Respiratory Medicine},
  title        = {Systemic CD4+ T-cell activation is correlated with FEV(1) in smokers.},
  url          = {http://dx.doi.org/10.1016/j.rmed.2005.09.025},
  volume       = {100},
  year         = {2006},
}