Visual outcome after fractionated stereotactic radiation therapy of benign anterior skull base tumors
Astradsson, Arnar ; Wiencke, Anne Katrine ; Munck Af Rosenschold, Per LU
; Engelholm, Svend Aage
; Ohlhues, Lars
; Roed, Henrik
and Juhler, Marianne
(2014)
In Journal of Neuro-Oncology
118(1).
p.101-108
- Abstract
To determine visual outcome including the occurrence of radiation induced optic neuropathy (RION) as well as tumor control after fractionated stereotactic radiation therapy (FSRT) of benign anterior skull base meningiomas or pituitary adenomas. Thirty-nine patients treated with FSRT for anterior skull base meningiomas and 55 patients treated with FSRT for pituitary adenomas between January 1999 and December 2009 with at least 2 years follow-up were included. Patients were followed up prospectively with magnetic resonance imaging scans, visual acuity and visual field examinations. RION was found in four (10 %) patients with anterior skull base meningiomas and seven patients (13 %) with pituitary adenomas. The five-year actuarial freedom... (More)
To determine visual outcome including the occurrence of radiation induced optic neuropathy (RION) as well as tumor control after fractionated stereotactic radiation therapy (FSRT) of benign anterior skull base meningiomas or pituitary adenomas. Thirty-nine patients treated with FSRT for anterior skull base meningiomas and 55 patients treated with FSRT for pituitary adenomas between January 1999 and December 2009 with at least 2 years follow-up were included. Patients were followed up prospectively with magnetic resonance imaging scans, visual acuity and visual field examinations. RION was found in four (10 %) patients with anterior skull base meningiomas and seven patients (13 %) with pituitary adenomas. The five-year actuarial freedom from 25 % RION visual field loss was 94 % following FSRT. Actuarial 2-, 5- and 10-year tumor control rates were 100, 88.4 and 64.5 % for anterior skull base meningiomas and 100, 98.2 and 94.9 % for pituitary adenomas, respectively. Patients with an impaired visual field function pre-FSRT were more likely to experience worsened function (p = 0.016). We found that RION, was a relatively uncommon event, in a large prospective cohort of patients that were systematically monitored following FSRT of benign anterior skull base tumors. Long term tumor control was favorable, especially for pituitary adenomas.
(Less)
- author
- Astradsson, Arnar
; Wiencke, Anne Katrine
; Munck Af Rosenschold, Per
LU
; Engelholm, Svend Aage
; Ohlhues, Lars
; Roed, Henrik
and Juhler, Marianne
- publishing date
- 2014-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Anterior skull base meningiomas, Fractionated stereotactic radiation therapy, Pituitary adenomas, Radiation induced optic neuropathy, Tumor control, Visual outcome
- in
- Journal of Neuro-Oncology
- volume
- 118
- issue
- 1
- pages
- 8 pages
- publisher
- Springer
- external identifiers
-
- scopus:84901637488
- pmid:24532196
- ISSN
- 0167-594X
- DOI
- 10.1007/s11060-014-1399-0
- language
- English
- LU publication?
- no
- id
- 5ae98f2e-f85e-45dd-b6a3-52958c8b8d41
- date added to LUP
- 2020-07-28 08:47:55
- date last changed
- 2024-05-29 18:38:13
@article{5ae98f2e-f85e-45dd-b6a3-52958c8b8d41,
abstract = {{<p>To determine visual outcome including the occurrence of radiation induced optic neuropathy (RION) as well as tumor control after fractionated stereotactic radiation therapy (FSRT) of benign anterior skull base meningiomas or pituitary adenomas. Thirty-nine patients treated with FSRT for anterior skull base meningiomas and 55 patients treated with FSRT for pituitary adenomas between January 1999 and December 2009 with at least 2 years follow-up were included. Patients were followed up prospectively with magnetic resonance imaging scans, visual acuity and visual field examinations. RION was found in four (10 %) patients with anterior skull base meningiomas and seven patients (13 %) with pituitary adenomas. The five-year actuarial freedom from 25 % RION visual field loss was 94 % following FSRT. Actuarial 2-, 5- and 10-year tumor control rates were 100, 88.4 and 64.5 % for anterior skull base meningiomas and 100, 98.2 and 94.9 % for pituitary adenomas, respectively. Patients with an impaired visual field function pre-FSRT were more likely to experience worsened function (p = 0.016). We found that RION, was a relatively uncommon event, in a large prospective cohort of patients that were systematically monitored following FSRT of benign anterior skull base tumors. Long term tumor control was favorable, especially for pituitary adenomas.</p>}},
author = {{Astradsson, Arnar and Wiencke, Anne Katrine and Munck Af Rosenschold, Per and Engelholm, Svend Aage and Ohlhues, Lars and Roed, Henrik and Juhler, Marianne}},
issn = {{0167-594X}},
keywords = {{Anterior skull base meningiomas; Fractionated stereotactic radiation therapy; Pituitary adenomas; Radiation induced optic neuropathy; Tumor control; Visual outcome}},
language = {{eng}},
month = {{01}},
number = {{1}},
pages = {{101--108}},
publisher = {{Springer}},
series = {{Journal of Neuro-Oncology}},
title = {{Visual outcome after fractionated stereotactic radiation therapy of benign anterior skull base tumors}},
url = {{http://dx.doi.org/10.1007/s11060-014-1399-0}},
doi = {{10.1007/s11060-014-1399-0}},
volume = {{118}},
year = {{2014}},
}