Advanced

Krebs´ citric acid cycle

Hederstedt, Lars LU (1993) In <em>Bacillus</em> and other gram-positive bacteria p.181-197
Abstract
The citric acid cycle (CAC) has several functions in aerobic bacteria. Together with the pyruvate dehydrogenase multienzyme complex (PDHC), it completely oxidizes pyruvate and provides membrane-bound respiratory systems with reducing equivalents. An overview of the biochemistry and genetics of CAC enzymes in B. subtilis is presented in this chapter. B. subtilis, being a strict aerobe, runs a complete CAC, as is demonstrated by enzyme activity measurements with cell extracts or purified enzymes and by the ability of this bacterium to grow on most of the intermediates of the CAC as sole carbon source. 2-oxoglutarate dehydrogenase multienzyme complex (ODHC) belongs to the same family of enzymes as PDHC. Present knowledge of this enzyme, has... (More)
The citric acid cycle (CAC) has several functions in aerobic bacteria. Together with the pyruvate dehydrogenase multienzyme complex (PDHC), it completely oxidizes pyruvate and provides membrane-bound respiratory systems with reducing equivalents. An overview of the biochemistry and genetics of CAC enzymes in B. subtilis is presented in this chapter. B. subtilis, being a strict aerobe, runs a complete CAC, as is demonstrated by enzyme activity measurements with cell extracts or purified enzymes and by the ability of this bacterium to grow on most of the intermediates of the CAC as sole carbon source. 2-oxoglutarate dehydrogenase multienzyme complex (ODHC) belongs to the same family of enzymes as PDHC. Present knowledge of this enzyme, has been acquired from studies involving various B. subtilis mutants. The prosthetic groups of B. subtilis SQR and some of their properties are presented in this chapter. The occurrence of larger and smaller types of malate dehydrogenase seems not to be correlated with gram-positive or gram-negative bacteria as citrate synthase and succinate thiokinase are. Little information on the genetics of malate dehydrogenase in gram-positive bacteria is available, but B. subtilis mutants defective in this CAC enzyme have been isolated. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
in
<em>Bacillus</em> and other gram-positive bacteria
editor
Sonenshein, Abraham L.; Hoch, James A.; Losick, Richard; ; and
pages
181 - 197
publisher
ASM Press
DOI
10.1128/9781555818388
language
English
LU publication?
yes
id
5aef413a-65e6-49d7-9bb3-c7c926f2b889
date added to LUP
2017-07-18 10:24:31
date last changed
2017-09-27 09:11:42
@inbook{5aef413a-65e6-49d7-9bb3-c7c926f2b889,
  abstract     = {The citric acid cycle (CAC) has several functions in aerobic bacteria. Together with the pyruvate dehydrogenase multienzyme complex (PDHC), it completely oxidizes pyruvate and provides membrane-bound respiratory systems with reducing equivalents. An overview of the biochemistry and genetics of CAC enzymes in B. subtilis is presented in this chapter. B. subtilis, being a strict aerobe, runs a complete CAC, as is demonstrated by enzyme activity measurements with cell extracts or purified enzymes and by the ability of this bacterium to grow on most of the intermediates of the CAC as sole carbon source. 2-oxoglutarate dehydrogenase multienzyme complex (ODHC) belongs to the same family of enzymes as PDHC. Present knowledge of this enzyme, has been acquired from studies involving various B. subtilis mutants. The prosthetic groups of B. subtilis SQR and some of their properties are presented in this chapter. The occurrence of larger and smaller types of malate dehydrogenase seems not to be correlated with gram-positive or gram-negative bacteria as citrate synthase and succinate thiokinase are. Little information on the genetics of malate dehydrogenase in gram-positive bacteria is available, but B. subtilis mutants defective in this CAC enzyme have been isolated. },
  author       = {Hederstedt, Lars},
  editor       = {Sonenshein, Abraham L. and Hoch, James A. and Losick, Richard},
  language     = {eng},
  pages        = {181--197},
  publisher    = {ASM Press},
  series       = {<em>Bacillus</em> and other gram-positive bacteria},
  title        = {Krebs´ citric acid cycle},
  url          = {http://dx.doi.org/10.1128/9781555818388 },
  year         = {1993},
}