Anti-inflammatory effects of contralateral administration of the kappa-opioid agonist U-50,488H in rats with unilaterally induced adjuvant arthritis
(2006) In Rheumatology 45(3). p.295-302- Abstract
- Objective. The effect of repeated contralateral treatment with the kappa-opioid receptor agonist U-50,488H {trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]-ben zene acetamide methanesulphonate} was investigated in rats with unilaterally induced adjuvant arthritis. Methods. Arthritis was induced by injection of Mycobacterium butyricum into the right hindpaw. Inflammatory parameters, nociceptive behaviour and cartilage turnover were evaluated up to 21 days after induction of arthritis. Results. Contralateral treatment with 0.3 mg U-50,488H into the left hindpaw twice per week reduced the hindpaw oedema, ankle joint inflammation, pain behaviour to mechanical stimuli and severity score of inflammation in the hindpaws of... (More)
- Objective. The effect of repeated contralateral treatment with the kappa-opioid receptor agonist U-50,488H {trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]-ben zene acetamide methanesulphonate} was investigated in rats with unilaterally induced adjuvant arthritis. Methods. Arthritis was induced by injection of Mycobacterium butyricum into the right hindpaw. Inflammatory parameters, nociceptive behaviour and cartilage turnover were evaluated up to 21 days after induction of arthritis. Results. Contralateral treatment with 0.3 mg U-50,488H into the left hindpaw twice per week reduced the hindpaw oedema, ankle joint inflammation, pain behaviour to mechanical stimuli and severity score of inflammation in the hindpaws of both sides as well as the systemic spread of inflammation to other areas, e.g. tail and/or forepaws, compared with saline-treated animals. Moreover, a significant decrease in the levels of cartilage oligomeric matrix protein was found in animals treated with U-50,488H, suggesting reduction of cartilage damage. The anti-inflammatory and chondroprotective effects of U-50,488H were abolished by administration of the peripheral opioid receptor antagonist naloxone methiodide. Conclusions. This is the first report demonstrating that repeated contralateral administration of a kappa-opioid receptor agonist diminishes the development of a symmetrical joint disorder. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/417045
- author
- Bileviciute-Ljungar, I ; Saxne, Tore LU and Spetea, M
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- rats, adjuvant arthritis, oligomeric matrix protein, cartilage, 488H, U-50, contralateral treatment, kappa-opioid agonist
- in
- Rheumatology
- volume
- 45
- issue
- 3
- pages
- 295 - 302
- publisher
- Oxford University Press
- external identifiers
-
- pmid:16249243
- wos:000235604500010
- scopus:33644871177
- pmid:16249243
- ISSN
- 1462-0332
- DOI
- 10.1093/rheumatology/kei156
- language
- English
- LU publication?
- yes
- id
- 5b092761-927d-4132-90d9-3d76f280d0e6 (old id 417045)
- date added to LUP
- 2016-04-01 15:28:40
- date last changed
- 2022-03-06 23:52:34
@article{5b092761-927d-4132-90d9-3d76f280d0e6,
abstract = {{Objective. The effect of repeated contralateral treatment with the kappa-opioid receptor agonist U-50,488H {trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]-ben zene acetamide methanesulphonate} was investigated in rats with unilaterally induced adjuvant arthritis. Methods. Arthritis was induced by injection of Mycobacterium butyricum into the right hindpaw. Inflammatory parameters, nociceptive behaviour and cartilage turnover were evaluated up to 21 days after induction of arthritis. Results. Contralateral treatment with 0.3 mg U-50,488H into the left hindpaw twice per week reduced the hindpaw oedema, ankle joint inflammation, pain behaviour to mechanical stimuli and severity score of inflammation in the hindpaws of both sides as well as the systemic spread of inflammation to other areas, e.g. tail and/or forepaws, compared with saline-treated animals. Moreover, a significant decrease in the levels of cartilage oligomeric matrix protein was found in animals treated with U-50,488H, suggesting reduction of cartilage damage. The anti-inflammatory and chondroprotective effects of U-50,488H were abolished by administration of the peripheral opioid receptor antagonist naloxone methiodide. Conclusions. This is the first report demonstrating that repeated contralateral administration of a kappa-opioid receptor agonist diminishes the development of a symmetrical joint disorder.}},
author = {{Bileviciute-Ljungar, I and Saxne, Tore and Spetea, M}},
issn = {{1462-0332}},
keywords = {{rats; adjuvant arthritis; oligomeric matrix protein; cartilage; 488H; U-50; contralateral treatment; kappa-opioid agonist}},
language = {{eng}},
number = {{3}},
pages = {{295--302}},
publisher = {{Oxford University Press}},
series = {{Rheumatology}},
title = {{Anti-inflammatory effects of contralateral administration of the kappa-opioid agonist U-50,488H in rats with unilaterally induced adjuvant arthritis}},
url = {{http://dx.doi.org/10.1093/rheumatology/kei156}},
doi = {{10.1093/rheumatology/kei156}},
volume = {{45}},
year = {{2006}},
}