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No evidence for shedding of circulating tumor cells to the peripheral venous blood as a result of mammographic breast compression.

Förnvik, Daniel LU ; Andersson, Ingvar LU ; Dustler, Magnus LU ; Ehrnström, Roy LU ; Rydén, Lisa LU ; Tingberg, Anders LU ; Zackrisson, Sophia LU and Aaltonen, Kristina LU (2013) In Breast Cancer Research and Treatment 141(2). p.187-195
Abstract
This pilot study aimed to investigate whether mammographic compression procedures might cause shedding of tumor cells into the circulatory system as reflected by circulating tumor cell (CTC) count in peripheral venous blood samples. From March to October 2012, 24 subjects with strong suspicion of breast malignancy were included in the study. Peripheral blood samples were acquired before and after mammography. Enumeration of CTCs in the blood samples was performed using the CellSearch(®) system. The pressure distribution over the tumor-containing breast was measured using thin pressure sensors. The median age was 66.5 years (range, 51-87 years). In 22 of the 24 subjects, breast cancer was subsequently confirmed. The difference between the... (More)
This pilot study aimed to investigate whether mammographic compression procedures might cause shedding of tumor cells into the circulatory system as reflected by circulating tumor cell (CTC) count in peripheral venous blood samples. From March to October 2012, 24 subjects with strong suspicion of breast malignancy were included in the study. Peripheral blood samples were acquired before and after mammography. Enumeration of CTCs in the blood samples was performed using the CellSearch(®) system. The pressure distribution over the tumor-containing breast was measured using thin pressure sensors. The median age was 66.5 years (range, 51-87 years). In 22 of the 24 subjects, breast cancer was subsequently confirmed. The difference between the average mean tumor pressure 6.8 ± 5.3 kPa (range, 1.0-22.5 kPa) and the average mean breast pressure 3.4 ± 1.6 kPa (range, 1.5-7.1 kPa) was statistically significant (p < 0.001), confirming that there was increased pressure over the tumor. The median pathological tumor size was 19 mm (range, 9-30 mm). Four subjects (17 %) were CTC positive before compression and two of these (8 %) were also CTC positive after compression. A total of seven CTCs were isolated with a mean size of 8 × 6 μm(2) (range of the longest diameter, 5-12 μm). The study supports the view that mammography is a safe procedure from the point of view of tumor cell shedding to the peripheral blood. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Breast Cancer Research and Treatment
volume
141
issue
2
pages
187 - 195
publisher
Springer
external identifiers
  • wos:000325008500003
  • pmid:23990353
  • scopus:84885324020
ISSN
1573-7217
DOI
10.1007/s10549-013-2674-z
language
English
LU publication?
yes
id
5b2b08c1-56a7-477a-91db-0cd5b3aba9e6 (old id 4005235)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23990353?dopt=Abstract
date added to LUP
2013-09-05 14:21:54
date last changed
2019-07-30 01:00:55
@article{5b2b08c1-56a7-477a-91db-0cd5b3aba9e6,
  abstract     = {This pilot study aimed to investigate whether mammographic compression procedures might cause shedding of tumor cells into the circulatory system as reflected by circulating tumor cell (CTC) count in peripheral venous blood samples. From March to October 2012, 24 subjects with strong suspicion of breast malignancy were included in the study. Peripheral blood samples were acquired before and after mammography. Enumeration of CTCs in the blood samples was performed using the CellSearch(®) system. The pressure distribution over the tumor-containing breast was measured using thin pressure sensors. The median age was 66.5 years (range, 51-87 years). In 22 of the 24 subjects, breast cancer was subsequently confirmed. The difference between the average mean tumor pressure 6.8 ± 5.3 kPa (range, 1.0-22.5 kPa) and the average mean breast pressure 3.4 ± 1.6 kPa (range, 1.5-7.1 kPa) was statistically significant (p &lt; 0.001), confirming that there was increased pressure over the tumor. The median pathological tumor size was 19 mm (range, 9-30 mm). Four subjects (17 %) were CTC positive before compression and two of these (8 %) were also CTC positive after compression. A total of seven CTCs were isolated with a mean size of 8 × 6 μm(2) (range of the longest diameter, 5-12 μm). The study supports the view that mammography is a safe procedure from the point of view of tumor cell shedding to the peripheral blood.},
  author       = {Förnvik, Daniel and Andersson, Ingvar and Dustler, Magnus and Ehrnström, Roy and Rydén, Lisa and Tingberg, Anders and Zackrisson, Sophia and Aaltonen, Kristina},
  issn         = {1573-7217},
  language     = {eng},
  number       = {2},
  pages        = {187--195},
  publisher    = {Springer},
  series       = {Breast Cancer Research and Treatment},
  title        = {No evidence for shedding of circulating tumor cells to the peripheral venous blood as a result of mammographic breast compression.},
  url          = {http://dx.doi.org/10.1007/s10549-013-2674-z},
  volume       = {141},
  year         = {2013},
}