Ethanol prevents development of destructive arthritis
(2007) In Proceedings of the National Academy of Sciences 104(1). p.258-263- Abstract
- Environmental factors are thought to play a major role in the development of rheumatoid arthritis. Because the use of ethanol is widespread, we assessed the role of ethanol intake on the propensity to develop chronic arthritis. Collagen type II-immunized mice were given water or water containing 10% (vol/vol) ethanol or its metabolite acetaldehyde. Their development of arthritis was assessed, as well as the impact of ethanol on leukocyte migration and activation of intracellular transcription factors. Mice exposed daily to this dose of ethanol did not display any liver toxicity, and the development of erosive arthritis was almost totally abrogated. In contrast, the anti body-mediated effector phase of collagen-induced arthritis was not... (More)
- Environmental factors are thought to play a major role in the development of rheumatoid arthritis. Because the use of ethanol is widespread, we assessed the role of ethanol intake on the propensity to develop chronic arthritis. Collagen type II-immunized mice were given water or water containing 10% (vol/vol) ethanol or its metabolite acetaldehyde. Their development of arthritis was assessed, as well as the impact of ethanol on leukocyte migration and activation of intracellular transcription factors. Mice exposed daily to this dose of ethanol did not display any liver toxicity, and the development of erosive arthritis was almost totally abrogated. In contrast, the anti body-mediated effector phase of collagen-induced arthritis was not influenced by ethanol exposure. Also, the major ethanol metabolite, acetaldehyde, prevented the development of arthritis. This antiinflammatory and antidestructive property of ethanol was mediated by (i) down-regulation of leukocyte migration and (ii) up-regulation of testosterone secretion, with the latter leading to decreased NF-kappa B activation. We conclude that low but persistent ethanol consumption delays the onset and halts the progression of collagen-induced arthritis by interaction with innate immune responsiveness. (Less)
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https://lup.lub.lu.se/record/676833
- author
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- antibodies, sex hormones, inflammation, cytokines, immunity
- in
- Proceedings of the National Academy of Sciences
- volume
- 104
- issue
- 1
- pages
- 258 - 263
- publisher
- National Academy of Sciences
- external identifiers
-
- wos:000243456300048
- scopus:33846033048
- pmid:17185416
- ISSN
- 1091-6490
- DOI
- 10.1073/pnas.0608620104
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)
- id
- 5b346128-a94a-4bb5-a03f-f4341e7636b4 (old id 676833)
- date added to LUP
- 2016-04-01 12:29:21
- date last changed
- 2022-03-29 01:35:25
@article{5b346128-a94a-4bb5-a03f-f4341e7636b4, abstract = {{Environmental factors are thought to play a major role in the development of rheumatoid arthritis. Because the use of ethanol is widespread, we assessed the role of ethanol intake on the propensity to develop chronic arthritis. Collagen type II-immunized mice were given water or water containing 10% (vol/vol) ethanol or its metabolite acetaldehyde. Their development of arthritis was assessed, as well as the impact of ethanol on leukocyte migration and activation of intracellular transcription factors. Mice exposed daily to this dose of ethanol did not display any liver toxicity, and the development of erosive arthritis was almost totally abrogated. In contrast, the anti body-mediated effector phase of collagen-induced arthritis was not influenced by ethanol exposure. Also, the major ethanol metabolite, acetaldehyde, prevented the development of arthritis. This antiinflammatory and antidestructive property of ethanol was mediated by (i) down-regulation of leukocyte migration and (ii) up-regulation of testosterone secretion, with the latter leading to decreased NF-kappa B activation. We conclude that low but persistent ethanol consumption delays the onset and halts the progression of collagen-induced arthritis by interaction with innate immune responsiveness.}}, author = {{Jonsson, Ing-Marie and Verdrengh, Margareta and Brisslert, Mikael and Lindblad, Sofia and Bokarewa, Maria and Islander, Ulrika and Carlsten, Hans and Ohlsson, Claes and Nandakumar, Kutty Selva and Holmdahl, Rikard and Tarkowski, Andrej}}, issn = {{1091-6490}}, keywords = {{antibodies; sex hormones; inflammation; cytokines; immunity}}, language = {{eng}}, number = {{1}}, pages = {{258--263}}, publisher = {{National Academy of Sciences}}, series = {{Proceedings of the National Academy of Sciences}}, title = {{Ethanol prevents development of destructive arthritis}}, url = {{http://dx.doi.org/10.1073/pnas.0608620104}}, doi = {{10.1073/pnas.0608620104}}, volume = {{104}}, year = {{2007}}, }