New directions in non-porous membrane extraction
(2000)- Abstract
- Complex biological and environmental samples require a high degree of selectivity in order to determine components therein. Sensitivity measures, such as analyte pre-concentration are often required for assessing composition quantitatively. Use of membranes and especially non-porous membranes for extraction purposes offers in many cases the desired measure of selectivity and sensitivity for trace analysis from such samples. Selected species can be either permanently charged, ionogenic or neutral, and range in size from protons to proteins. The result of the extractions is often excellent cleanup of the matrix and a decrease in detection limits. Another salient feature with these systems is that they offer an extremely low consumption of... (More)
- Complex biological and environmental samples require a high degree of selectivity in order to determine components therein. Sensitivity measures, such as analyte pre-concentration are often required for assessing composition quantitatively. Use of membranes and especially non-porous membranes for extraction purposes offers in many cases the desired measure of selectivity and sensitivity for trace analysis from such samples. Selected species can be either permanently charged, ionogenic or neutral, and range in size from protons to proteins. The result of the extractions is often excellent cleanup of the matrix and a decrease in detection limits. Another salient feature with these systems is that they offer an extremely low consumption of potentially hazardous, organic solvents. The work in this thesis has focused on novel approaches within the field of non-porous membrane extraction, including system integration and automation, miniaturisation and extensions of technical scope and applicability. Integration has been designed to suit a number of important techniques, such as normal-phase and reversed-phase liquid chromatography (LC), capillary-LC, gas chromatography (GC), capillary electrophoresis (CE) and continuous-flow systems (FIA/SIA). The development of a miniaturised membrane unit, carrying a single hollow fibre, was devised and integrated with capillary-LC and with CE. An easy connection between membrane based liquid-liquid extraction and GC has been proposed. Extending the applicability of non-porous membrane extractions, antibodies have been used for selective recognition and trapping. (Less)
- Abstract (Swedish)
- Popular Abstract in Swedish
Avhandlingen berör membranbaserade tekniker för provupparbetning, vilket enkelt uttryckt innebär att använda membran för att ”skilja agnarna från vetet”. De membran som använts kan designas för att vara selektivt genomsläppliga, d.vs. släppa igenom vissa molekyler och inte andra. Denna selektivitet behöver inte vara baserad på molekylstorlek, tvärtom styrs den mer av molekylernas laddning och ”vattenskräck”. För att generalisera kan man säga att ämnen är antingen mer lösliga i vatten eller i organiska ämnen. Hur som helst, separerar membranet intressanta föreningar ifrån de föreningar som annars skulle försvåra eller omöjliggöra analysen. Viktigt här är också att membranet tillåter anrikning av... (More) - Popular Abstract in Swedish
Avhandlingen berör membranbaserade tekniker för provupparbetning, vilket enkelt uttryckt innebär att använda membran för att ”skilja agnarna från vetet”. De membran som använts kan designas för att vara selektivt genomsläppliga, d.vs. släppa igenom vissa molekyler och inte andra. Denna selektivitet behöver inte vara baserad på molekylstorlek, tvärtom styrs den mer av molekylernas laddning och ”vattenskräck”. För att generalisera kan man säga att ämnen är antingen mer lösliga i vatten eller i organiska ämnen. Hur som helst, separerar membranet intressanta föreningar ifrån de föreningar som annars skulle försvåra eller omöjliggöra analysen. Viktigt här är också att membranet tillåter anrikning av de intressanta föreningarna, d.v.s. halten av ämnena är högre i slutprovet än i ursprungsprovet. En annan central del har varit att koppla dessa membran till instrument som separerar provkomponenterna ifrån varandra och slutligen mäter halterna. Ett genomgående spår i arbetet har varit miniatyrisering och den problematik som omger denna. Fördelar med att miniatyrisera är bl.a. ökad hanterbarhet av små provvolymer (ex. blodprover ur barn) samt minskad användning av dyra och hälsofarliga organiska lösningsmedel (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/40800
- author
- Thordarson, Eddie LU
- supervisor
- opponent
-
- Dr Majors, Ron E., Hewlett Packard, Delaware, USA
- organization
- publishing date
- 2000
- type
- Thesis
- publication status
- published
- subject
- keywords
- extracting syringe, solvent-free, miniaturisation, micro-porous membrane liquid-liquid extraction, polymeric membrane extraction, Non-porous membrane extraction, supported liquid extraction, integration, automation, Analytical chemistry, Analytisk kemi
- pages
- 120 pages
- publisher
- Department of Analytical Chemistry, Lund University
- defense location
- Hörsal A at the Chemical Center
- defense date
- 2000-10-13 13:13:00
- external identifiers
-
- other:ISRN: LUNKDL/(NKAK-1055)/(2000)
- language
- English
- LU publication?
- yes
- additional info
- Article: I. Sample Preparation Using a Miniaturized Supported Liquid Membrane Device Connected On-line to Packed Capillary Liquid ChromatographyE. Thordarson; S. Pálmarsdóttir; L. Mathiasson and J. Å. JönssonAnal. Chem. 1996, 68, 2559-2563II. Miniaturized supported liquid membrane device for selective on-line enrichment of basic drugs in plasma combined with capillary zone electrophoresisS. Pálmarsdóttir; E. Thordarson; L-E. Edholm; J. Å. Jönsson; L. MathiassonAnal. Chem. 1997, 69, 1732-1737III. Microporous membrane liquid-liquid extraction coupled on-line with normal-phase liquid chromatography for the determination of cationic surfactants in river and waste-waterJ. Norberg, E. Thordarson, L. Mathiasson, J. Å. JönssonJ. Chromatogr. 2000, 869, 523-529IV. Automated liquid membrane extraction for high-performance liquid chromatography of Ropivacaine metabolites in urineJ. Å. Jönsson, M. Andersson, C. Melander, J. Norberg, E. Thordarson, L. MathiassonJ. Chromatogr. 2000, 870, 151-157V. Extracting Syringe-connecting sample preparation and gas chromatographyJ. Norberg and E. ThordarsonAnalyst, 2000, 125, 673-676VI. Automated Extraction of BTEX from urine samples utilising the Extracting Syringe: Screening of GC Injection ParametersE. Thordarson, S. Bergström, A. Mie, J. Å. Jönsson, J. NorbergManuscriptVII. Immunologic Trapping in Supported Liquid Membrane ExtractionE. Thordarson, J. Å. Jönsson, J. EmnéusAnal. Chem., accepted The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Analytical Chemistry (S/LTH) (011001004)
- id
- 5b349c8a-bfd4-4924-9702-fdf6c490d01a (old id 40800)
- date added to LUP
- 2016-04-04 12:22:27
- date last changed
- 2018-11-21 21:10:34
@phdthesis{5b349c8a-bfd4-4924-9702-fdf6c490d01a,
abstract = {{Complex biological and environmental samples require a high degree of selectivity in order to determine components therein. Sensitivity measures, such as analyte pre-concentration are often required for assessing composition quantitatively. Use of membranes and especially non-porous membranes for extraction purposes offers in many cases the desired measure of selectivity and sensitivity for trace analysis from such samples. Selected species can be either permanently charged, ionogenic or neutral, and range in size from protons to proteins. The result of the extractions is often excellent cleanup of the matrix and a decrease in detection limits. Another salient feature with these systems is that they offer an extremely low consumption of potentially hazardous, organic solvents. The work in this thesis has focused on novel approaches within the field of non-porous membrane extraction, including system integration and automation, miniaturisation and extensions of technical scope and applicability. Integration has been designed to suit a number of important techniques, such as normal-phase and reversed-phase liquid chromatography (LC), capillary-LC, gas chromatography (GC), capillary electrophoresis (CE) and continuous-flow systems (FIA/SIA). The development of a miniaturised membrane unit, carrying a single hollow fibre, was devised and integrated with capillary-LC and with CE. An easy connection between membrane based liquid-liquid extraction and GC has been proposed. Extending the applicability of non-porous membrane extractions, antibodies have been used for selective recognition and trapping.}},
author = {{Thordarson, Eddie}},
keywords = {{extracting syringe; solvent-free; miniaturisation; micro-porous membrane liquid-liquid extraction; polymeric membrane extraction; Non-porous membrane extraction; supported liquid extraction; integration; automation; Analytical chemistry; Analytisk kemi}},
language = {{eng}},
publisher = {{Department of Analytical Chemistry, Lund University}},
school = {{Lund University}},
title = {{New directions in non-porous membrane extraction}},
year = {{2000}},
}