Renal tubular dysfunction after urinary diversion
(1995) In Scandinavian Journal of Urology and Nephrology 29(4). p.407-412- Abstract
Renal tubular function can be assessed by measuring low molecular weight proteins in urine. In the present study, urinary levels of protein HC, also called alpha 1-microglobulin, were determined in 84 patients, 3-17 years after conduit diversion or continent urinary reconstruction. Increased excretion of protein HC, indicating tubular dysfunction, was found in 30 patients (36%), but was slight in most cases. Among patients with GFR > 45 ml/min/1.73 m2 at latest follow-up, the fall from preoperative GFR was greater in those with elevated levels of protein HC than in those with normal levels (p < 0.01). No permeation of protein HC through the intestinal mucosa in contact with urine could be demonstrated. Urinary protein HC may be a... (More)
Renal tubular function can be assessed by measuring low molecular weight proteins in urine. In the present study, urinary levels of protein HC, also called alpha 1-microglobulin, were determined in 84 patients, 3-17 years after conduit diversion or continent urinary reconstruction. Increased excretion of protein HC, indicating tubular dysfunction, was found in 30 patients (36%), but was slight in most cases. Among patients with GFR > 45 ml/min/1.73 m2 at latest follow-up, the fall from preoperative GFR was greater in those with elevated levels of protein HC than in those with normal levels (p < 0.01). No permeation of protein HC through the intestinal mucosa in contact with urine could be demonstrated. Urinary protein HC may be a suitable marker for detecting early renal impairment after urinary diversion.
(Less)
- author
- Kristjansson, A ; Grubb, A LU and Månsson, W LU
- publishing date
- 1995
- type
- Contribution to journal
- publication status
- published
- keywords
- Adolescent, Adult, Aged, Aged, 80 and over, Alpha-Globulins/urine, Child, Female, Glomerular Filtration Rate/physiology, Humans, Kidney Function Tests, Kidney Tubules/physiopathology, Male, Middle Aged, Postoperative Complications/diagnosis, Protease Inhibitors/urine, Proteinuria/diagnosis, Reference Values, Urinary Bladder Neoplasms/surgery, Urinary Bladder, Neurogenic/surgery, Urinary Diversion, Urinary Reservoirs, Continent
- in
- Scandinavian Journal of Urology and Nephrology
- volume
- 29
- issue
- 4
- pages
- 407 - 412
- publisher
- Taylor & Francis
- external identifiers
-
- scopus:0029557630
- pmid:8719357
- ISSN
- 0036-5599
- DOI
- 10.3109/00365599509180021
- language
- English
- LU publication?
- no
- id
- 5b4ffad1-adba-40ad-843b-c55a44c9eabb
- date added to LUP
- 2021-10-28 14:02:11
- date last changed
- 2024-01-12 02:56:37
@article{5b4ffad1-adba-40ad-843b-c55a44c9eabb, abstract = {{<p>Renal tubular function can be assessed by measuring low molecular weight proteins in urine. In the present study, urinary levels of protein HC, also called alpha 1-microglobulin, were determined in 84 patients, 3-17 years after conduit diversion or continent urinary reconstruction. Increased excretion of protein HC, indicating tubular dysfunction, was found in 30 patients (36%), but was slight in most cases. Among patients with GFR > 45 ml/min/1.73 m2 at latest follow-up, the fall from preoperative GFR was greater in those with elevated levels of protein HC than in those with normal levels (p < 0.01). No permeation of protein HC through the intestinal mucosa in contact with urine could be demonstrated. Urinary protein HC may be a suitable marker for detecting early renal impairment after urinary diversion.</p>}}, author = {{Kristjansson, A and Grubb, A and Månsson, W}}, issn = {{0036-5599}}, keywords = {{Adolescent; Adult; Aged; Aged, 80 and over; Alpha-Globulins/urine; Child; Female; Glomerular Filtration Rate/physiology; Humans; Kidney Function Tests; Kidney Tubules/physiopathology; Male; Middle Aged; Postoperative Complications/diagnosis; Protease Inhibitors/urine; Proteinuria/diagnosis; Reference Values; Urinary Bladder Neoplasms/surgery; Urinary Bladder, Neurogenic/surgery; Urinary Diversion; Urinary Reservoirs, Continent}}, language = {{eng}}, number = {{4}}, pages = {{407--412}}, publisher = {{Taylor & Francis}}, series = {{Scandinavian Journal of Urology and Nephrology}}, title = {{Renal tubular dysfunction after urinary diversion}}, url = {{http://dx.doi.org/10.3109/00365599509180021}}, doi = {{10.3109/00365599509180021}}, volume = {{29}}, year = {{1995}}, }