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Renal tubular dysfunction after urinary diversion

Kristjansson, A ; Grubb, A LU orcid and Månsson, W LU (1995) In Scandinavian Journal of Urology and Nephrology 29(4). p.407-412
Abstract

Renal tubular function can be assessed by measuring low molecular weight proteins in urine. In the present study, urinary levels of protein HC, also called alpha 1-microglobulin, were determined in 84 patients, 3-17 years after conduit diversion or continent urinary reconstruction. Increased excretion of protein HC, indicating tubular dysfunction, was found in 30 patients (36%), but was slight in most cases. Among patients with GFR > 45 ml/min/1.73 m2 at latest follow-up, the fall from preoperative GFR was greater in those with elevated levels of protein HC than in those with normal levels (p < 0.01). No permeation of protein HC through the intestinal mucosa in contact with urine could be demonstrated. Urinary protein HC may be a... (More)

Renal tubular function can be assessed by measuring low molecular weight proteins in urine. In the present study, urinary levels of protein HC, also called alpha 1-microglobulin, were determined in 84 patients, 3-17 years after conduit diversion or continent urinary reconstruction. Increased excretion of protein HC, indicating tubular dysfunction, was found in 30 patients (36%), but was slight in most cases. Among patients with GFR > 45 ml/min/1.73 m2 at latest follow-up, the fall from preoperative GFR was greater in those with elevated levels of protein HC than in those with normal levels (p < 0.01). No permeation of protein HC through the intestinal mucosa in contact with urine could be demonstrated. Urinary protein HC may be a suitable marker for detecting early renal impairment after urinary diversion.

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author
; and
publishing date
type
Contribution to journal
publication status
published
keywords
Adolescent, Adult, Aged, Aged, 80 and over, Alpha-Globulins/urine, Child, Female, Glomerular Filtration Rate/physiology, Humans, Kidney Function Tests, Kidney Tubules/physiopathology, Male, Middle Aged, Postoperative Complications/diagnosis, Protease Inhibitors/urine, Proteinuria/diagnosis, Reference Values, Urinary Bladder Neoplasms/surgery, Urinary Bladder, Neurogenic/surgery, Urinary Diversion, Urinary Reservoirs, Continent
in
Scandinavian Journal of Urology and Nephrology
volume
29
issue
4
pages
407 - 412
publisher
Taylor & Francis
external identifiers
  • scopus:0029557630
  • pmid:8719357
ISSN
0036-5599
DOI
10.3109/00365599509180021
language
English
LU publication?
no
id
5b4ffad1-adba-40ad-843b-c55a44c9eabb
date added to LUP
2021-10-28 14:02:11
date last changed
2024-01-12 02:56:37
@article{5b4ffad1-adba-40ad-843b-c55a44c9eabb,
  abstract     = {{<p>Renal tubular function can be assessed by measuring low molecular weight proteins in urine. In the present study, urinary levels of protein HC, also called alpha 1-microglobulin, were determined in 84 patients, 3-17 years after conduit diversion or continent urinary reconstruction. Increased excretion of protein HC, indicating tubular dysfunction, was found in 30 patients (36%), but was slight in most cases. Among patients with GFR &gt; 45 ml/min/1.73 m2 at latest follow-up, the fall from preoperative GFR was greater in those with elevated levels of protein HC than in those with normal levels (p &lt; 0.01). No permeation of protein HC through the intestinal mucosa in contact with urine could be demonstrated. Urinary protein HC may be a suitable marker for detecting early renal impairment after urinary diversion.</p>}},
  author       = {{Kristjansson, A and Grubb, A and Månsson, W}},
  issn         = {{0036-5599}},
  keywords     = {{Adolescent; Adult; Aged; Aged, 80 and over; Alpha-Globulins/urine; Child; Female; Glomerular Filtration Rate/physiology; Humans; Kidney Function Tests; Kidney Tubules/physiopathology; Male; Middle Aged; Postoperative Complications/diagnosis; Protease Inhibitors/urine; Proteinuria/diagnosis; Reference Values; Urinary Bladder Neoplasms/surgery; Urinary Bladder, Neurogenic/surgery; Urinary Diversion; Urinary Reservoirs, Continent}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{407--412}},
  publisher    = {{Taylor & Francis}},
  series       = {{Scandinavian Journal of Urology and Nephrology}},
  title        = {{Renal tubular dysfunction after urinary diversion}},
  url          = {{http://dx.doi.org/10.3109/00365599509180021}},
  doi          = {{10.3109/00365599509180021}},
  volume       = {{29}},
  year         = {{1995}},
}