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Beyond boundaries: exploring the role of extracellular vesicles in organ-specific metastasis in solid tumors

Nidhi, Goutham LU ; Yadav, Vikas LU orcid ; Singh, Tejveer ; Sharma, Deepika ; Bohot, Monica and Satapathy, Shakti Ranjan LU (2025) In Frontiers in Immunology 16. p.01-15
Abstract
Extracellular vesicles (EVs) have been identified as important mediators of cancer metastasis, especially in the establishment of organ-specific metastatic niches. These membranous vesicles secreted by tumor cells release diverse bioactive cargo, including proteins, nucleic acids, and lipids, thereby allowing for intercellular communication and microenvironment modulation. Recent evidence demonstrates that EVs can also contribute to the formation of pre-metastatic niches by reprogramming immune cells, modifying the stromal environment, and inducing epithelial-mesenchymal transition (EMT) to promote metastatic colonization. In this review, we describe the molecular mechanism of organotropic metastasis orchestrated by EVs, with special... (More)
Extracellular vesicles (EVs) have been identified as important mediators of cancer metastasis, especially in the establishment of organ-specific metastatic niches. These membranous vesicles secreted by tumor cells release diverse bioactive cargo, including proteins, nucleic acids, and lipids, thereby allowing for intercellular communication and microenvironment modulation. Recent evidence demonstrates that EVs can also contribute to the formation of pre-metastatic niches by reprogramming immune cells, modifying the stromal environment, and inducing epithelial-mesenchymal transition (EMT) to promote metastatic colonization. In this review, we describe the molecular mechanism of organotropic metastasis orchestrated by EVs, with special emphasis on immune modulation and tumor microenvironment reprogramming. We also explore the potential of EVs as biomarkers for early detection of metastasis and as potential therapeutic targets for combating metastatic progression. Dissociating EV species and their influence on tumor dissemination will undoubtedly pave the way for implementing novel anti-cancer strategies to intercept tumor dissemination at its very early stages. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Frontiers in Immunology
volume
16
article number
1593834
pages
01 - 15
publisher
Frontiers Media S. A.
ISSN
1664-3224
DOI
10.3389/fimmu.2025.1593834
language
English
LU publication?
yes
id
5b502e86-4599-44e6-a6e3-a3622d99134c
date added to LUP
2025-06-27 14:56:05
date last changed
2025-06-30 08:19:16
@article{5b502e86-4599-44e6-a6e3-a3622d99134c,
  abstract     = {{Extracellular vesicles (EVs) have been identified as important mediators of cancer metastasis, especially in the establishment of organ-specific metastatic niches. These membranous vesicles secreted by tumor cells release diverse bioactive cargo, including proteins, nucleic acids, and lipids, thereby allowing for intercellular communication and microenvironment modulation. Recent evidence demonstrates that EVs can also contribute to the formation of pre-metastatic niches by reprogramming immune cells, modifying the stromal environment, and inducing epithelial-mesenchymal transition (EMT) to promote metastatic colonization. In this review, we describe the molecular mechanism of organotropic metastasis orchestrated by EVs, with special emphasis on immune modulation and tumor microenvironment reprogramming. We also explore the potential of EVs as biomarkers for early detection of metastasis and as potential therapeutic targets for combating metastatic progression. Dissociating EV species and their influence on tumor dissemination will undoubtedly pave the way for implementing novel anti-cancer strategies to intercept tumor dissemination at its very early stages.}},
  author       = {{Nidhi, Goutham and Yadav, Vikas and Singh, Tejveer and Sharma, Deepika and Bohot, Monica and Satapathy, Shakti Ranjan}},
  issn         = {{1664-3224}},
  language     = {{eng}},
  month        = {{06}},
  pages        = {{01--15}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Immunology}},
  title        = {{Beyond boundaries: exploring the role of extracellular vesicles in organ-specific metastasis in solid tumors}},
  url          = {{http://dx.doi.org/10.3389/fimmu.2025.1593834}},
  doi          = {{10.3389/fimmu.2025.1593834}},
  volume       = {{16}},
  year         = {{2025}},
}