Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays
Staaf, Johan LU
; Lindgren, David
LU
; Vallon-Christersson, Johan
LU
; Isaksson, Anders
; Goransson, Hanna
; Juliusson, Gunnar
LU
; Rosenquist, Richard
; Höglund, Mattias
LU
; Borg, Åke
LU
and Ringnér, Markus
LU
(2008)
In Genome Biology
9(9).
- Abstract
- We present a strategy for detection of loss-of-heterozygosity and allelic imbalance in cancer cells from whole genome single nucleotide polymorphism genotyping data. Using a dilution series of a tumor cell line mixed with its paired normal cell line and data generated on Affymetrix and Illumina platforms, including paired tumor-normal samples and tumors characterized by fluorescent in situ hybridization, we demonstrate a high sensitivity and specificity of the strategy for detecting both minute and gross allelic imbalances in heterogeneous tumor samples.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1283451
- author
- Staaf, Johan
LU
; Lindgren, David
LU
; Vallon-Christersson, Johan
LU
; Isaksson, Anders
; Goransson, Hanna
; Juliusson, Gunnar
LU
; Rosenquist, Richard
; Höglund, Mattias
LU
; Borg, Åke
LU
and Ringnér, Markus
LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Genome Biology
- volume
- 9
- issue
- 9
- article number
- R136
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000260586900014
- scopus:53349171050
- ISSN
- 1474-7596
- DOI
- 10.1186/gb-2008-9-9-r136
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Hematology/Transplantation (013022014), Division of Clinical Genetics (013022003), Oncology, MV (013035000)
- id
- 5b54b24b-1df9-486f-8ea5-522e65f79402 (old id 1283451)
- date added to LUP
- 2016-04-01 11:57:11
- date last changed
- 2022-06-09 03:43:38
@article{5b54b24b-1df9-486f-8ea5-522e65f79402,
abstract = {{We present a strategy for detection of loss-of-heterozygosity and allelic imbalance in cancer cells from whole genome single nucleotide polymorphism genotyping data. Using a dilution series of a tumor cell line mixed with its paired normal cell line and data generated on Affymetrix and Illumina platforms, including paired tumor-normal samples and tumors characterized by fluorescent in situ hybridization, we demonstrate a high sensitivity and specificity of the strategy for detecting both minute and gross allelic imbalances in heterogeneous tumor samples.}},
author = {{Staaf, Johan and Lindgren, David and Vallon-Christersson, Johan and Isaksson, Anders and Goransson, Hanna and Juliusson, Gunnar and Rosenquist, Richard and Höglund, Mattias and Borg, Åke and Ringnér, Markus}},
issn = {{1474-7596}},
language = {{eng}},
number = {{9}},
publisher = {{BioMed Central (BMC)}},
series = {{Genome Biology}},
title = {{Segmentation-based detection of allelic imbalance and loss-of-heterozygosity in cancer cells using whole genome SNP arrays}},
url = {{http://dx.doi.org/10.1186/gb-2008-9-9-r136}},
doi = {{10.1186/gb-2008-9-9-r136}},
volume = {{9}},
year = {{2008}},
}