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Left ventricular remodelling changes without concomitant loss of myocardial fat after long-term dietary intervention

Andersson, Jonas ; Mellberg, Caroline LU ; Otten, Julia ; Ryberg, Mats ; Rinnström, Daniel ; Larsson, Christel ; Lindahl, Bernt ; Hauksson, Jon ; Johansson, Bengt and Olsson, Tommy (2016) In International Journal of Cardiology 216. p.6-92
Abstract

BACKGROUND: Accumulation of myocardial triglycerides (MTG) is associated with impaired left ventricular (LV) remodelling and function in obese and diabetic subjects. The role of MTG accumulation in development of heart failure in this group of patients is unknown. Short-term studies suggest that diets that lead to weight loss could mobilize MTG, with a favourable effect on cardiac remodelling. In a 24-month, randomized, investigator-blinded study, we assessed the effect of two different diets and subsequent weight loss on cardiac function and MTG in postmenopausal women.

METHODS: Sixty-eight healthy postmenopausal women with body mass index [BMI] ≥27kg/m(2) were randomized to an ad libitum Palaeolithic diet (PD) or a Nordic... (More)

BACKGROUND: Accumulation of myocardial triglycerides (MTG) is associated with impaired left ventricular (LV) remodelling and function in obese and diabetic subjects. The role of MTG accumulation in development of heart failure in this group of patients is unknown. Short-term studies suggest that diets that lead to weight loss could mobilize MTG, with a favourable effect on cardiac remodelling. In a 24-month, randomized, investigator-blinded study, we assessed the effect of two different diets and subsequent weight loss on cardiac function and MTG in postmenopausal women.

METHODS: Sixty-eight healthy postmenopausal women with body mass index [BMI] ≥27kg/m(2) were randomized to an ad libitum Palaeolithic diet (PD) or a Nordic Nutrition Recommendation (NNR) diet for 24months. Morphology, cardiac function, and MTG levels were measured using magnetic resonance (MR) scanning, including proton spectroscopy at baseline and 6 and 24months.

RESULTS: Despite mean weight losses of 4.9 (1.0) kg (NNR) and 7.8 (1.1) kg (PD), the MTG content did not change over time (p=0.98 in the NNR and p=0.11 in the PD group at 24months). Reduced left ventricular mass was observed in both diet groups over 24months. Blood pressure was reduced at 6months, but returned to baseline levels at 24months. End diastolic volume, stroke volume, and cardiac output decreased over time. No differences between diet groups were observed.

CONCLUSIONS: Diet intervention and moderate weight loss over 24months improved LV remodelling but did not alter MTG levels in overweight/obese postmenopausal women.

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author
; ; ; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Journal Article
in
International Journal of Cardiology
volume
216
pages
5 pages
publisher
Elsevier
external identifiers
  • scopus:84964765661
  • pmid:27149238
ISSN
0167-5273
DOI
10.1016/j.ijcard.2016.04.050
language
English
LU publication?
no
id
5b5f8799-9ef8-4570-b1ff-8705a05d6ee6
date added to LUP
2017-04-20 17:11:31
date last changed
2024-10-14 04:38:27
@article{5b5f8799-9ef8-4570-b1ff-8705a05d6ee6,
  abstract     = {{<p>BACKGROUND: Accumulation of myocardial triglycerides (MTG) is associated with impaired left ventricular (LV) remodelling and function in obese and diabetic subjects. The role of MTG accumulation in development of heart failure in this group of patients is unknown. Short-term studies suggest that diets that lead to weight loss could mobilize MTG, with a favourable effect on cardiac remodelling. In a 24-month, randomized, investigator-blinded study, we assessed the effect of two different diets and subsequent weight loss on cardiac function and MTG in postmenopausal women.</p><p>METHODS: Sixty-eight healthy postmenopausal women with body mass index [BMI] ≥27kg/m(2) were randomized to an ad libitum Palaeolithic diet (PD) or a Nordic Nutrition Recommendation (NNR) diet for 24months. Morphology, cardiac function, and MTG levels were measured using magnetic resonance (MR) scanning, including proton spectroscopy at baseline and 6 and 24months.</p><p>RESULTS: Despite mean weight losses of 4.9 (1.0) kg (NNR) and 7.8 (1.1) kg (PD), the MTG content did not change over time (p=0.98 in the NNR and p=0.11 in the PD group at 24months). Reduced left ventricular mass was observed in both diet groups over 24months. Blood pressure was reduced at 6months, but returned to baseline levels at 24months. End diastolic volume, stroke volume, and cardiac output decreased over time. No differences between diet groups were observed.</p><p>CONCLUSIONS: Diet intervention and moderate weight loss over 24months improved LV remodelling but did not alter MTG levels in overweight/obese postmenopausal women.</p>}},
  author       = {{Andersson, Jonas and Mellberg, Caroline and Otten, Julia and Ryberg, Mats and Rinnström, Daniel and Larsson, Christel and Lindahl, Bernt and Hauksson, Jon and Johansson, Bengt and Olsson, Tommy}},
  issn         = {{0167-5273}},
  keywords     = {{Journal Article}},
  language     = {{eng}},
  month        = {{08}},
  pages        = {{6--92}},
  publisher    = {{Elsevier}},
  series       = {{International Journal of Cardiology}},
  title        = {{Left ventricular remodelling changes without concomitant loss of myocardial fat after long-term dietary intervention}},
  url          = {{http://dx.doi.org/10.1016/j.ijcard.2016.04.050}},
  doi          = {{10.1016/j.ijcard.2016.04.050}},
  volume       = {{216}},
  year         = {{2016}},
}