Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Major depressive episodes over the course of 7 years and hippocampal subfield volumes at 7 tesla MRI : the PREDICT-MR study

Wisse, L E M LU orcid ; Biessels, G J ; Stegenga, B T ; Kooistra, M ; van der Veen, P H ; Zwanenburg, J J M ; van der Graaf, Y and Geerlings, M I (2015) In Journal of Affective Disorders 175. p.1-7
Abstract

INTRODUCTION: Smaller hippocampal volumes have been associated with major depressive disorder (MDD). The hippocampus consists of several subfields that may be differentially related to MDD. We investigated the association of occurrence of major depressive episodes (MDEs), assessed five times over seven years, with hippocampal subfield and entorhinal cortex volumes at 7 tesla MRI.

METHODS: In this prospective study of randomly selected general practice attendees, MDEs according to DSM-IV-R criteria were assessed at baseline and after 6, 12, 39 and 84 months follow-up. At the last follow-up, a T2 (0.7 mm(3)) 7 tesla MRI scan was obtained in 47 participants (60±10 years). The subiculum, cornu ammonis (CA) 1 to 3, dentate... (More)

INTRODUCTION: Smaller hippocampal volumes have been associated with major depressive disorder (MDD). The hippocampus consists of several subfields that may be differentially related to MDD. We investigated the association of occurrence of major depressive episodes (MDEs), assessed five times over seven years, with hippocampal subfield and entorhinal cortex volumes at 7 tesla MRI.

METHODS: In this prospective study of randomly selected general practice attendees, MDEs according to DSM-IV-R criteria were assessed at baseline and after 6, 12, 39 and 84 months follow-up. At the last follow-up, a T2 (0.7 mm(3)) 7 tesla MRI scan was obtained in 47 participants (60±10 years). The subiculum, cornu ammonis (CA) 1 to 3, dentate gyrus&CA4 and entorhinal cortex volumes were manually segmented according a published protocol.

RESULTS: Of the 47 participants, 13 had one MDE and 5 had multiple MDEs. ANCOVAs, adjusted for age, sex, education and intracranial volume, revealed no significant differences in hippocampal subfield or entorhinal cortex volumes between participants with and without an MDE in the preceding 84 months. Multiple episodes were associated with smaller subiculum volumes (B=-0.03 mL/episode; 95% CI -0.06; -0.003), but not with the other hippocampal subfield volumes, entorhinal cortex, or total hippocampal volume.

LIMITATIONS: A limitation of this study is the small sample size which makes replication necessary.

CONCLUSIONS: In this exploratory study, we found that an increasing number of major depressive episodes was associated with smaller subiculum volumes in middle-aged and older persons, but not with smaller volumes in other hippocampal subfields or the entorhinal cortex.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Aged, Atrophy/pathology, Depressive Disorder, Major/pathology, Diagnostic and Statistical Manual of Mental Disorders, Entorhinal Cortex/pathology, Female, Hippocampus/pathology, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuroimaging, Prospective Studies, Time Factors
in
Journal of Affective Disorders
volume
175
pages
1 - 7
publisher
Elsevier
external identifiers
  • scopus:84920677930
  • pmid:25589378
ISSN
0165-0327
DOI
10.1016/j.jad.2014.12.052
language
English
LU publication?
no
additional info
Copyright © 2014 Elsevier B.V. All rights reserved.
id
5b614cf7-8818-45a3-b1a4-90e65ef3a549
date added to LUP
2024-02-28 15:00:37
date last changed
2024-02-29 09:20:41
@article{5b614cf7-8818-45a3-b1a4-90e65ef3a549,
  abstract     = {{<p>INTRODUCTION: Smaller hippocampal volumes have been associated with major depressive disorder (MDD). The hippocampus consists of several subfields that may be differentially related to MDD. We investigated the association of occurrence of major depressive episodes (MDEs), assessed five times over seven years, with hippocampal subfield and entorhinal cortex volumes at 7 tesla MRI.</p><p>METHODS: In this prospective study of randomly selected general practice attendees, MDEs according to DSM-IV-R criteria were assessed at baseline and after 6, 12, 39 and 84 months follow-up. At the last follow-up, a T2 (0.7 mm(3)) 7 tesla MRI scan was obtained in 47 participants (60±10 years). The subiculum, cornu ammonis (CA) 1 to 3, dentate gyrus&amp;CA4 and entorhinal cortex volumes were manually segmented according a published protocol.</p><p>RESULTS: Of the 47 participants, 13 had one MDE and 5 had multiple MDEs. ANCOVAs, adjusted for age, sex, education and intracranial volume, revealed no significant differences in hippocampal subfield or entorhinal cortex volumes between participants with and without an MDE in the preceding 84 months. Multiple episodes were associated with smaller subiculum volumes (B=-0.03 mL/episode; 95% CI -0.06; -0.003), but not with the other hippocampal subfield volumes, entorhinal cortex, or total hippocampal volume.</p><p>LIMITATIONS: A limitation of this study is the small sample size which makes replication necessary.</p><p>CONCLUSIONS: In this exploratory study, we found that an increasing number of major depressive episodes was associated with smaller subiculum volumes in middle-aged and older persons, but not with smaller volumes in other hippocampal subfields or the entorhinal cortex.</p>}},
  author       = {{Wisse, L E M and Biessels, G J and Stegenga, B T and Kooistra, M and van der Veen, P H and Zwanenburg, J J M and van der Graaf, Y and Geerlings, M I}},
  issn         = {{0165-0327}},
  keywords     = {{Aged; Atrophy/pathology; Depressive Disorder, Major/pathology; Diagnostic and Statistical Manual of Mental Disorders; Entorhinal Cortex/pathology; Female; Hippocampus/pathology; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuroimaging; Prospective Studies; Time Factors}},
  language     = {{eng}},
  month        = {{04}},
  pages        = {{1--7}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Affective Disorders}},
  title        = {{Major depressive episodes over the course of 7 years and hippocampal subfield volumes at 7 tesla MRI : the PREDICT-MR study}},
  url          = {{http://dx.doi.org/10.1016/j.jad.2014.12.052}},
  doi          = {{10.1016/j.jad.2014.12.052}},
  volume       = {{175}},
  year         = {{2015}},
}